A5083302068- Mosquito-borne diseases and control
- Yersinia bacterium, plague, ectoparasites research
- Antibiotic Resistance in Bacteria
- Rabies epidemiology and control
- HIV Research and Treatment
- Sphingolipid Metabolism and Signaling
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Escherichia coli research studies
- interferon and immune responses
- Enterobacteriaceae and Cronobacter Research
- Respiratory and Cough-Related Research
- Bacterial Identification and Susceptibility Testing
- Advanced Measurement and Detection Methods
- Virus-based gene therapy research
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Medical Imaging Techniques and Applications
- Bat Biology and Ecology Studies
- Hepatitis C virus research
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Andrographolide Research and Applications
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2022-2025
Universidad Autónoma de Madrid
2025
Consejo Superior de Investigaciones Científicas
2023-2025
Instituto Cajal
2020-2021
Instituto Ramón y Cajal de Investigación Sanitaria
2020-2021
Instituto de Salud Carlos III
2018-2019
Universidad de Cantabria
2012
This is a longitudinal study comprising 649 Escherichia coli isolates representing all 7,165 E. bloodstream infection (BSI) episodes recorded in hospital (1996 to 2016). Strain analysis included clonal identification (phylogenetic groups/subgroups, STc131 subclades, pulsed-field gel electrophoresis [PFGE], and whole-genome sequencing [WGS]), antibiotic susceptibility (13 antibiotics), virulence-associated genes (VAGs; 29 genes). The incidence of BSI increased from 1996 2016 (5.5 10.8...
West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected mosquitoes. Severe forms disease (WND) can curse with meningitis, encephalitis or acute flaccid paralysis. A better understanding physiopathology associated progression mandatory to find biomarkers and effective therapies. In this scenario, blood derivatives (plasma serum) constitute more commonly used biofluids due its ease collection high value for diagnostic purposes. Therefore, potential impact in...
The flavivirus life cycle is strictly dependent on cellular lipid metabolism. Polyphenols like gallic acid and its derivatives are promising lead compounds for new therapeutic agents as they can exert multiple pharmacological activities, including the alteration of evaluation our collection polyphenols against West Nile virus (WNV), a representative medically relevant flavivirus, led to identification N,N'-(dodecane-1,12-diyl)bis(3,4,5-trihydroxybenzamide) 2,3,4-trihydroxybenzamide...
Cryptic speciation and hybridization are two key processes that affect the origin maintenance of biodiversity our ability to understand estimate it. To determine how these interact, we studied allopatric sympatric colonies cryptic bat species (Eptesicus serotinus Eptesicus isabellinus) with parapatric distribution in Iberian Peninsula. These main reservoir for most commonly rabies virus found bats Europe: European Lyssavirus type 1 (EBLV-1). We used mtDNA nuclear microsatellite markers...
Previous studies have shown that EBLV-1 strains exclusively hosted by Eptesicus isabellinus bats in the Iberian Peninsula cluster a specific monophyletic group is related to EBLV-1b lineage found rest of Europe. More recently, enhanced passive surveillance has allowed detection first associated serotinus south Pyrenees. The aim this study reconstruction phylogeny and phylodynamics context European continent. We sequenced 23 detected on nine E. 14 isabellinus. Phylogenetic analyses were...
An archetypal anti-inflammatory compound against cytokine storm would inhibit it without suppressing the innate immune response. AG5, an compound, has been developed as synthetic derivative of andrographolide, which is highly absorbable and presents low toxicity. We found that mechanism action AG5 through inhibition caspase-1. Interestingly, we show with in vitro generated human monocyte derived dendritic cells preserves minimizes inflammatory response a mouse model lipopolysaccharide...
Flavivirus comprises globally emerging and re-emerging pathogens such as Zika virus (ZIKV), Dengue (DENV), West Nile (WNV), among others. Although some vaccines are available, there is an unmet medical need no effective antiviral treatment has been approved for flaviviral infections. The development of host-directed antivirals (HDAs) targeting host factors that essential viral replication cycle offers the opportunity broad-spectrum antivirals. In case flaviviruses, recent studies have...
This paper outlines a pre-processing technique to improve the stabilisation and matching results of thermal imaging sequences online welding monitoring processes, where measurements have been affected by vibrations in sensor holder structure. For that purpose, used method, based on point tracking direct phase substitution, will be described subsequently tested with two thermogram sequences, one obtained laboratory other from process.
The emergence of SARS-CoV-2 in 2019 and its rapid spread throughout the world has caused largest pandemic our modern era. zoonotic origin this pathogen highlights importance One Health concept need for a coordinated response to kind threath. Since emergence, virus >7 million deaths worldwide. However, animal source human outbreaks remains unknown. ability jump between hosts is facilitated by presence receptor, highly conserved angiotensin-converting enzyme 2 (ACE2), found various mammals....
ABSTRACT This is a longitudinal study comprising 649 Escherichia coli (EC) isolates representing all 7165 EC-BSI episodes recorded in hospital (1996-2016). Strains analysis included clonal identification (phylogenetic groups/subgroups, STc131 subclades, PFGE, and WGS), antibiotic susceptibility (13 antibiotics), virulence-associated genes (VAGs, 29 genes). The incidence of BSI-EC increased from 1996 to 2016 (5.5 10.8 BSI episodes/1000 hospitalizations, average 7-8/1000). B2 predominate...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
ABSTRACT Flavivirus life cycle is strictly dependent on cellular lipid metabolism. Polyphenols like gallic acid and its derivatives are promising lead compounds for new therapeutic agents as they can exert multiple pharmacological activities, including the alteration of The evaluation our own collection polyphenols against West Nile virus, a representative medically relevant flavivirus, led to identification N,N ′-(dodecane-1,12-diyl)bis(3,4,5-trihydroxybenzamide) 2,3,4-trihydroxybenzamide...