A5015892865- Immunotherapy and Immune Responses
- COVID-19 Impact on Reproduction
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
Technical University of Denmark
2019-2024
National Institute for Public Health and the Environment
2024
Abstract In this study we performed a step-wise optimization of biologically active IL-2 for delivery using E. coli Nissle 1917. Engineering the strain was coupled with an in vitro cell assay to measure biological activity microbially produced (mi-IL2). Next, assessed immune modulatory potential mi-IL2 3D tumor spheroid model demonstrating strong effect on activation. Finally, evaluated anticancer properties engineered murine CT26 model. The injected intravenously and selectively colonized...
Introduction Accumulating evidence indicates the importance of T cell immunity in vaccination-induced protection against severe COVID-19 disease, especially SARS-CoV-2 Variants-of-Concern (VOCs) that more readily escape from recognition by neutralizing antibodies. However, there is limited knowledge on responses across different age groups and impact CMV status after primary booster vaccination with vaccine combinations. Moreover, it remains unclear whether has an effect ability cells to...
Abstract The UV-mediated peptide exchange has enabled the generation of multiple different MHC multimer specificities in parallel, surpassing tedious individual refolding molecules with ligands. Murine models are acknowledged as an effective tool for preclinical research to advance our understanding immunological mechanisms, potential translatability key learnings from mouse clinic. common inbred strain BALB/c is frequently used research. However, histocompatibility (H)-2 alleles...