A5038016900- Respiratory viral infections research
- Statistical Methods and Inference
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Statistical Methods in Clinical Trials
- Virology and Viral Diseases
- Insurance, Mortality, Demography, Risk Management
- Statistical Methods and Bayesian Inference
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Bayesian Methods and Mixture Models
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Noise Effects and Management
- Traffic and Road Safety
- Monoclonal and Polyclonal Antibodies Research
- Random Matrices and Applications
- Respiratory Support and Mechanisms
- Immune responses and vaccinations
- COVID-19 Impact on Reproduction
- Point processes and geometric inequalities
- Medical and Biological Sciences
- Health disparities and outcomes
National Institute for Public Health and the Environment
2020-2025
UCLouvain
2018
Ghent University
2016
Leiden University Medical Center
2008-2015
Transylvania University of Brașov
2008-2010
Leiden University
2008
In older adults, pneumococcal disease is strongly associated with respiratory viral infections, but the impact of viruses on Streptococcus pneumoniae carriage prevalence and load remains poorly understood. Here, we investigated effects influenza-like illness (ILI) in community-dwelling adults.We presence DNA saliva samples collected 2014/2015 influenza season from 232 individuals aged ≥60 years at ILI onset, followed by sampling 2-3 weeks 7-9 after first sample. We also sampled 194...
People aged 60 years or older are at high risk for respiratory infections, one of the leading causes mortality worldwide. Vaccination is main way to protect against these infections; however, vaccination less effective in adults than younger due ageing immune system, so innovative strategies that improve vaccine responses could provide a major public health benefit. The gut microbiota regulates host homoeostasis and response pathogens, but human studies showing effects on infections sparse....
Influenza-like illness (ILI) can be caused by a range of respiratory viruses. The present study investigates the contribution influenza and other viruses, occurrence viral co-infections, persistence viruses after ILI onset in older adults. During season 2014–2015, 2366 generally healthy community-dwelling adults (≥60 years) were enrolled study. Viruses identified multiplex ligation–dependent probe-amplification assay naso- oropharyngeal swabs taken during acute phase, 2 8 weeks later....
People who live near airports are exposed to higher concentrations of ultrafine particles (UFPs) from aviation. Pregnant women and their fetuses, in particular, considered be highly susceptible environmental exposures. Using existing national databases, we investigated associations between adverse birth outcomes exposure UFPs aviation (UFP-aviation) at the residential address during pregnancy. We identified ∼286,000 singleton records (from 2006 2018) mothers who, for least 6 months...
We propose an extension of the landmark model for ordinary survival data as a new approach to problem dynamic prediction in competing risks with time‐dependent covariates. fix set time points t LM within follow‐up interval. For each these , we create by selecting individuals at risk ; value covariate . assume Cox proportional hazard models cause‐specific hazards and consider smoothing (possibly) effect different sets. Fitting this is possible standard statistical software. illustrate...
Mumps outbreaks and breakthrough infections of measles rubella have raised concerns about waning vaccine-induced immunity after two doses measles-mumps-rubella (MMR) vaccination. In the present follow-up study, serum IgG antibodies against mumps, rubella, as well functional neutralizing both mumps vaccine strain outbreak strains were measured longitudinally in young adults that received a third MMR (MMR3) dose. The mumps-specific virus antibody levels at 3 years vaccination still elevated...
Abstract We study an alternative approach for estimation in the competing risks framework, called vertical modeling. It is motivated by a decomposition of joint distribution time and cause failure. The two elements this are (1) failure (2) condition on Both model based observable quantities, namely total hazard relative cause‐specific hazards. can be implemented using standard software. hazards flexibly estimated multinomial logistic regression smoothing splines. show estimates cumulative...
Summary In this article, we propose a new approach to the problem of dynamic prediction survival data in presence competing risks as an extension landmark model for ordinary data. The key feature our method is introduction pseudo-observations constructed from probabilities at different times. They specifically address issue estimating covariate effects directly on cumulative incidence scale risks. A flexible generalized linear based these and estimation equations estimate baseline will...
Abstract Background Young children and older adults are susceptible for invasive pneumococcal disease (IPD) caused by Streptococcus pneumoniae. Pneumococcal protein-specific antibodies play a protective role against IPD; however, not much is known about the pace of acquisition, maturation, maintenance these throughout life. Methods Immunoglobulin G (IgG) IgA levels, avidity, and/or specificity to proteome in serum saliva from healthy young children, adults, with carriage status, were...
Abstract Objectives Increasing evidence suggests that Fc‐mediated antibody effector functions have an important role in protection against respiratory viruses, including SARS‐CoV‐2. However, limited data are available on the potential differences development, heterogeneity and durability of these responses children compared to adults. Methods Here, we assessed development spike S1‐specific serum antibody‐dependent cellular phagocytosis (ADCP), complement deposition (ADCD) natural killer cell...
To analyze kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (N-GAL) excretion post-intravenous contrast enhanced-CT (CE-CT) in patients with chronic disease (CKD).Patients were enrolled a trial on hydration regimes to prevent contrast-induced acute (CI-AKI). Blood urine samples taken at baseline, 4 - 6, 48 96 h post CE-CT. Urinary KIM-1 N-GAL values normalized for urinary creatinine levels, presented as medians 2.5 97.5 percentiles.Of the 511 patients, 10 (2%)...
Breakthrough infections of measles and mumps have raised concerns about the duration vaccine-induced immunity, which might be improved by a third dose measles-mumps-rubella vaccine (MMR3). Here we compared (IgG) antibody levels against measles, mumps, rubella in blood samples 9-year-old children young adults (18-25 years) following MMR2 MMR3, respectively. We found that, addition to boosting for all 3 components, MMR3 resulted lower decay rates than MMR2; declines were most prominent...
Introduction Current human papillomavirus (HPV) vaccines consist of virus-like particles (VLPs) which are based on the L1 protein, but they produced by different expression systems and use adjuvants. We performed in-depth immunophenotyping multiple innate adaptive immune cells after vaccination with bivalent versus nonavalent HPV vaccines. Method Twenty pre-menopausal HPV-seronegative women were enrolled randomized to receive three-doses either or vaccine. Blood samples collected at time...
Streptococcus pneumoniae is a leading cause of morbidity and mortality in children older adults. Yet knowledge on the development pneumococcal protein-specific antibody responses throughout life limited. To investigate this, we measured serum IgG levels to 55 proteins 11-month old infants (n=73), 24-month (n=101), parents (n=99), adults without <6 years age (n= 99) aged >60 (n=100). Our findings revealed low infancy, with distinct patterns peaking A decrease was observed for 27 antigens...
Introduction Accumulating evidence indicates the importance of T cell immunity in vaccination-induced protection against severe COVID-19 disease, especially SARS-CoV-2 Variants-of-Concern (VOCs) that more readily escape from recognition by neutralizing antibodies. However, there is limited knowledge on responses across different age groups and impact CMV status after primary booster vaccination with vaccine combinations. Moreover, it remains unclear whether has an effect ability cells to...
Measles is a highly contagious disease presenting significant risk for unvaccinated infants and adults. vaccination under the age of 12 months provides early protection, but has also been associated with blunting antibody responses to subsequent measles vaccinations assumed have lower vaccine effectiveness.
To develop public health intervention models using micro-simulations, extensive personal information about inhabitants is needed, such as socio-demographic, economic and figures. Confidentiality an essential characteristic of data, while the data should reflect realistic scenarios. Collection possible only in secured environments not directly available for open-source micro-simulation models. The aim this paper to illustrate a method construction synthetic by predicting individual features...
ABSTRACT Background To characterize interferences between Streptococcus pneumoniae and SARS-CoV-2 we investigated the longitudinal patterns of viral infection pneumococcal carriage in households infected with SARS-CoV-2. Methods pneumococcus were detected quantitative molecular methods saliva from members eighty participating households. Samples collected October 2020 January 2021 n=197 adults n=118 children which n=176 n=98 had a complete set ten samples within 42 days since enrolment....
Background and aim: Studies have shown elevated concentrations of ultrafine particles (UFP) near airports. Little is known about the health effects UFP, in particular from aviation (UFP-aviation). We evaluated long-term exposure to UFP-aviation around Schiphol Airport, The Netherlands. Methods: investigated a wide range outcomes, by linking modelled annual average residential individual data existing registries surveys. conducted two longitudinal cohort studies, on mortality incidence...
Abstract Respiratory pathogens can cause severe disease and even death, especially in the very young old. Studies investigating their prevalence often focus on individuals presenting to healthcare providers with symptoms. However, design of prevention strategies, e.g. which target groups vaccinate, will benefit from knowledge of, risk factors for host response these general population. In this study, upper respiratory samples (n = 1311) were collected cross-sectionally during winter 11-...