A5020614847- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- Cell death mechanisms and regulation
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Ferroptosis and cancer prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- ATP Synthase and ATPases Research
- Cancer-related molecular mechanisms research
- Trace Elements in Health
- Inflammasome and immune disorders
- Atherosclerosis and Cardiovascular Diseases
- S100 Proteins and Annexins
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Apelin-related biomedical research
- Eicosanoids and Hypertension Pharmacology
- Biomarkers in Disease Mechanisms
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
Central South University
2016-2025
Third Xiangya Hospital
2019-2025
Xiangya Hospital Central South University
2012-2025
Second Xiangya Hospital of Central South University
2010
Hunan Normal University
2010
Recent studies have uncovered that accumulation of glutamate after ischaemic stroke is closely associated with the down-regulation transporter-1 (GLT-1) expression, suggesting GLT-1 expression critically controls and abnormal transport-elicited neuronal cell excitotoxicity in patients stroke. However, it remains unknown how regulated under conditions. In present study, we screened nine brain-specific or brain-enriched miRNAs a focal cerebral ischaemia/reperfusion (I/R) injury rat model,...
Recent studies show that resveratrol exerts beneficial effects on prevention of pulmonary hypertension. This study is performed to explore the trimethoxystilbene, a novel analog, rat vascular remodeling and right ventricular hypertrophy in hypoxia-induced arterial hypertension (PAH) underlying mechanisms. Sprague–Dawley rats were placed chamber exposed 10% O2 continuously for 4 weeks induce PAH. The trimethoxystilbene (5 or 10 mg/kg per day, intragastric [i.g.]) (as positive control, 25...
Objective Circulating microRNAs have been recognized as promising biomarkers for various diseases. The aim of the present study was to explore potential role circulating miR-107, miR-128b and miR-153 non-invasive in diagnosis ischemia stroke. Methods One hundred fourteen ischemic stroke patients (61±11.3 years old) 58 healthy volunteers (56±3.9 matched age sex were enrolled this study. Total RNA isolated from plasma with TRIzol reagent. levels measured by quantitative real-time polymerase...
Phenotypic transformation of vascular smooth muscle cells (VSMCs) contributes to remodeling in hypertension. High mobility group box-1 (HMGB1) has been reported be involved several pathogenic processes including VSMC proliferation and migration. The present study was designed determine the role HMGB1 phenotypic First, we demonstrated that elevated a model Ang II-induced transformation, which showed down-regulation contractile proteins up-regulation synthetic proteins. Knockdown losartan...
Background: Li Qi Huo Xue Di Wan (LQHXDW), a traditional Chinese medicine, is used to treat patients with the symptoms of palpitations, chest tightness, pain, and shortness breath. It not known, however, whether LQHXDW can reduce high-altitude hypoxia-induced cardiopulmonary injury, what are specific active ingredients, exact mechanism behind its protection. Objectives: This study intends investigate effect on injury underlying mechanisms. Methods: The components were identified by...