A5038552246- Fungal Biology and Applications
- Medicinal Plants and Bioactive Compounds
- Polysaccharides and Plant Cell Walls
- Pharmacological Effects of Natural Compounds
- Mycorrhizal Fungi and Plant Interactions
- Natural Antidiabetic Agents Studies
- Advanced Battery Technologies Research
- Zebrafish Biomedical Research Applications
- Phytochemistry and Bioactivity Studies
- Gut microbiota and health
- Gout, Hyperuricemia, Uric Acid
- Fuel Cells and Related Materials
- Congenital heart defects research
- Diet and metabolism studies
- Pancreatic function and diabetes
- Electric and Hybrid Vehicle Technologies
- Developmental Biology and Gene Regulation
- Seaweed-derived Bioactive Compounds
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Plant biochemistry and biosynthesis
- Silymarin and Mushroom Poisoning
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
Guangdong Academy of Sciences
2016-2025
Zhaoqing University
2024
Wuhan University of Technology
2020-2023
Ministry of Agriculture and Rural Affairs
2022-2023
Guangzhou Medical University
2014-2023
China National Heavy Duty Truck Group (China)
2023
Institute of Microbiology
2012-2022
Sichuan University
2010-2022
West China Hospital of Sichuan University
2014-2022
Chinese Academy of Sciences
2022
In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have protective effect on liver damage in mice caused by restraint stress through improving oxidative status. Two polysaccharides, including a neutral β-glucan (GLPB2) and an acidic (GLPC2) were purified from GLP anion-exchange chromatography (AEC) combined with gel permeation. GLPC2, average molecular weight of 20.56 kDa, exhibited stronger hepatoprotective against H2O2-induced injury HepG2 cells compared GLPB2....
This study demonstrated the hypoglycemic effects of <italic>Grifola frondosa</italic> polysaccharides F2 and F3 through insulin sensitivity improvement in diabetic rats.
Age-related changes in methylation are involved the occurrence and development of tumors, autoimmune disease, nervous system disorders, including Alzheimer’s disease (AD), elderly individuals; hence, modulation these may be an effective strategy to delay progression AD pathology. In this study, model rats were used screen main active fractions from mushroom, Ganoderma lucidum, for anti-aging properties, their effects on DNA evaluated. The results evaluation treated with 100 mg/kg/d...
Summary Grifola frondosa is an edible and medicinal fungus with various biological activities. Previously, we reported Gaylussacia polysaccharide F2 can improve insulin resistance in diabetic rats. In the present study, our aim was to identify its prebiotic function. The structure of obtained from gel permeation chromatography (GPC), Infrared (IR) spectroscopy saccharide mapping. Simulated digestion fecal bacteria fermentation vitro performed investigate characteristic. Dynamic changes...
Background/Objectives: Our lab has previously reported that Grifola frondosa (maitake mushroom) GF5000 antidiabetic potential owing to its ability improve insulin resistance. This study aimed gain insight into the system-level hypoglycemic mechanisms of using transcriptomics, proteomics, and network pharmacology. provides new insights GF5000, identifying key molecular targets involved in mitigating resistance T2DM. Methods: Liver protein gene expression normal control (NC), diabetic (DC),...
Prediabetes (pre-DM) is the buffer period before developing overt type 2 diabetes (T2DM), and search for novel food agents to protect against pre-DM in high demand. Our team previously reported that Grifola frondosa (maitake mushroom) polysaccharide F2 reduced insulin resistance T2DM rats induced by streptozocin (STZ) combined with a high-fat diet (HFD). This study aimed evaluate effects of G. on disordered lipid glucose metabolism investigate its mechanisms mice. (30 60 mg/kg/d) was...
Abstract Endothelial senescence is believed to constitute the initial pathogenesis of atherosclerotic cardiovascular disease (ASCVD). MicroRNA-335-5p (miR-335-5p) expression significantly up-regulated in oxidative stress-induced endothelial cells (ECs). Sirtuin7 (SIRT7) considered prevent EC senescence, yet data on its response ASCVD risk factors are limited. The present study analyzed elevated levels miR-335-5p and decreased SIRT7 human umbilical vein (HUVECs), found that high glucose,...
Inhibiting the intestinal α-glucosidase can effectively control postprandial hyperglycemia for type 2 diabetes mellitus (T2DM) treatment. In present study, we reported binding interaction of betulinic acid (BA), a pentacyclic triterpene widely distributed in nature, on and its alleviation hyperglycemia. BA was verified to exhibit strong inhibitory effect against with an IC50 value 16.83 ± 1.16 μM. More importantly, it showed synergistically acarbose. The underlying mechanism investigated by...
This study provides insight into the system-level hypoglycemic mechanisms of<italic>Ganoderma lucidum</italic>polysaccharides F31 by integrative analysis of transcriptomics and proteomics data.
Context Poria coco F.A.Wolf (Polyporaceae) dispels dampness and promotes diuresis implying hypouricaemic action.Objective To examine action of coco.Materials methods Ethanol extract (PCE) was prepared by extracting the sclerotium P. cocos with ethanol, water (PCW) produced bathing remains water. PCE PCW (50, 100 200 mg/kg, respectively) were orally administered to hyperuricemic Kunming mice (n = 8) its effect. Also, molecular docking performed.Results showed excellent action, decreasing...
The present study investigated the hypolipidaemic effects of Grifola frondosa and its regulation mechanism involved in lipid metabolism liver rats fed a high-cholesterol diet. body weights serum levels control rats, hyperlipidaemic treated with oral G. were determined. mRNA expression concentration key enzymes investigated. Serum cholesterol, triacylglycerol, low-density lipoprotein cholesterol markedly decreased compared untreated rats. 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR),...
The aim was to investigate whether Grifola frondosa fraction (Mw > 5000D) (GF5000) could restore the gut microbiota dysbiosis improves insulin resistance in diabetic rats. Oral glucose tolerance test and serum biochemical parameter were assessed of hypoglycemic activity GF5000 (112.5 675 mg/kg/d, i.g.) rats for 48 d. mRNA protein levels inflammatory markers epididymal white adipose tissue determined by qPCR western blotting. In intestinal tissue, sequencing V3-4 region 16S rRNA genes...
The chemical structure of GLP-1, a novel water-soluble heteropolysaccharide purified Ganoderma leucocontextum fruiting bodies, has been characterized in our previous study. This study aimed to investigate the immunostimulatory activity GLP-1 vitro and vivo by using RAW264.7 macrophages cyclophosphamide-induced immunosuppressed mice model. Results showed that was able enhance phagocytic promote production reactive oxygen species, nitric oxide, tumor necrosis factor-α, interleukin-6, monocyte...
The Snail family member snail encodes a zinc finger-containing transcriptional factor that is involved in heart formation. Yet, little known about how regulates development. Here, we identified one of the duplicated genes, snai1b, was expressed region zebrafish embryos. Depletion Snai1b function dramatically reduced expression α5 integrin, disrupted Fibronectin layer region, especially at midline and prevented migration cardiac precursors, resulting defects morphology Injection α5β1 protein...
A rapid in vitro enzymatic biosynthesis system has been developed as a biological manufacturing platform with potential industrial uses. Cytidine 5′-monophosphate (5′-CMP) is key intermediate the preparation of several nucleotide derivatives and widely used food pharmaceutical industries. In this study, highly efficient was constructed for 5′-CMP vitro. kinase (CK) biotransformation cytidine to 5′-CMP, while polyphosphate (PPK) coupled adenosine triphosphate regeneration. Both CK PPK were...