A5009065083- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Antifungal resistance and susceptibility
- Acute Lymphoblastic Leukemia research
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Eosinophilic Disorders and Syndromes
- Viral-associated cancers and disorders
- Iron Metabolism and Disorders
- Cancer Mechanisms and Therapy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Glycosylation and Glycoproteins Research
- Celiac Disease Research and Management
- COVID-19 and healthcare impacts
University of Pecs
2015-2025
University of Guelph
2024
Winship Cancer Institute
2023
Lymphoma Research Foundation
2023
Huntsman Cancer Institute
2023
University of Utah
2023
The University of Texas MD Anderson Cancer Center
2023
Vanderbilt University Medical Center
2023
Centennial Medical Center
2023
Sarah Cannon
2023
The performance of the Fungitell assay was investigated in 100 patients with haematological malignancy undergoing chemotherapy who developed antibiotic-unresponsive neutropenic fever (AUNF). Serum β - d -glucan (BG) concentrations were significantly elevated on first day AUNF and all subsequent alternate days to 10 38 an invasive fungal infection (IFI) compared 42 remaining free such infections. mean median values BG 171.9±29.6 95.8 pg ml −1 , respectively, for IFI 64.4±17.1 32.9 only ( P...
The oral, highly selective Bcl2 inhibitor venetoclax has substantially improved the therapeutic landscape of chronic lymphocytic leukemia (CLL). Despite remarkable response rates in patients with relapsed/refractory (R/R) disease, acquired resistance is leading cause treatment failure, somatic BCL2 mutations being predominant genetic drivers underpinning resistance. To assess correlation between disease progression and most common G101V D103Y, sensitive (10-4) screening for D103Y was...
Background: T-cell prolymphocytic leukemia (T-PLL) is a rare mature lymphoma that usually associated with poor prognosis and short overall survival. Methods: We present case of 61-year-old woman presenting T-PLL the leukemic cells harboring BCR::ABL1 (BCR-breakpoint cluster region; ABL1-ABL protooncogene 1) fusion transcripts as result variant t(9;22)(q34;q11) called Philadelphia translocation: t(9;22;18)(q34;q11;q21). Sequencing revealed BCR transcript an exon 6 breakpoint corresponding to...
Artificial Intelligence (AI) approaches in clinical science require extensive data preprocessing (DP) steps prior to building AI models. Establishing DP pipelines is a non-trivial task, mainly driven by purely mathematical rules and done scientists. Nevertheless, clinician presence shall be paramount at this step. The study proposes approach domain knowledge, where input, form of explicit non-explicit rules, directly impacts the algorithms' decision-making processes, thus, making planning...
Bevezető 2021-ben az anémia a világ népességének 24,3%-át érintette. Irodalmi adatok szerint súlyosbíthatja fertőzések lefolyását, és felvetődik, hogy anémiás állapot fokozhatja fertőzésekre való fogékonyságot. A COVID–19-pandémia lehetővé tette ezen hipotézis vizsgálatát. Célkitűzés Retrospektív vizsgálatunk célja COVID–19-betegség előfordulásának vizsgálata sürgősségi ellátást igénylő járóbetegek között. Módszer 2020 2022 között Pécsi Tudományegyetem – Klinikai Központ, Sürgősségi...
The diagnostic performance and usefulness of the Platelia antigen antibody test (Bio-Rad) was investigated in a prospective study haematological patients at risk for invasive Candida infections. Among 100 patients, 86 were eligible, whom candidiasis (IC) occurred 12 (14 %), according to criteria European Organization Research Treatment Cancer/Mycoses Study Group. These included candidaemia due albicans (one patient) or tropicalis (four patients), hepatosplenic (seven patients). comparator...
Primary central nervous system lymphomas (PCNSL) are aggressive non-Hodgkin affecting the (CNS). Although immunophenotyping studies suggested an uniform activated B-cell (ABC) origin, more recently a spectrum of ABC and germinal center (GC) cases has been proposed, with molecular subtypes PCNSL still being matter debate. With emergence novel therapies demonstrating different efficacy between GC patient groups, precise assignment subtype is becoming indispensable. To determine 77 17 secondary...
Ixazomib-Revlimid-Dexamethasone is an all-oral treatment protocol for multiple myeloma with a manageable tolerability profile which was available through named patient program Hungarian patients from December 2015 to April 2017. We analyzed the clinical characteristics and survival of 77 treated at 7 centers within this program. The majority responded, we found complete response in 9, very good partial 8, 32, minor or stable disease 13 progressive 11 patients. Progression free 11.4 months....
For the identification of high-risk patients in diffuse large B-cell lymphoma (DLBCL), we investigated prognostic significance vivo radiomics derived from baseline [18F]FDG PET/CT and clinical parameters.Pre-treatment scans 85 diagnosed with DLBCL were assessed. The carried out two centers. Two-year event-free survival (EFS) was defined. After delineation lesions, conventional PET parameters extracted. 2-year EFS prognosis assessment, Center 1 dataset utilized as training set underwent...
Background: Clopidogrel and proton pump inhibitors (PPIs) are metabolized by cytochrome P450 enzymes. Contradictory results have been reported on possible complications of simultaneous PPI clopidogrel use. Our aim was to investigate the clinical relevance this debate with a systematic review meta-analysis. Methods: The PubMed, Embase Cochrane Central Register Controlled Trials electronic databases were searched for human studies (randomized controlled trials (RCTs) observational studies)...
Summary The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has revolutionised the therapeutic landscape of chronic lymphocytic leukaemia (CLL). Acquired mutations emerging at position C481 in BTK domain are predominant genetic alterations associated with secondary resistance. To assess correlation between disease progression, and emergence temporal dynamics most common resistance mutation C481S , sensitive (10 −4 ) time‐resolved screening was performed 83 relapsed/refractory CLL patients...