A5048425467- Estrogen and related hormone effects
- Tissue Engineering and Regenerative Medicine
- Menopause: Health Impacts and Treatments
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Phytoestrogen effects and research
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Electrospun Nanofibers in Biomedical Applications
- Fatty Acid Research and Health
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Hormonal Regulation and Hypertension
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Prostate Cancer Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Hernia repair and management
- Stress Responses and Cortisol
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Lipoproteins and Cardiovascular Health
- Biomedical Ethics and Regulation
- Cellular Mechanics and Interactions
Forest Institute
2016-2025
Georgetown University
2014-2025
Atrium Health Wake Forest Baptist
1995-2025
Prostate Cancer Foundation
2012-2024
Wake Forest University
2014-2023
Winston-Salem State University
2011-2018
Seoul Medical Center
2018
SUNY Polytechnic Institute
2017
Walker (United States)
2014
Levine Cancer Institute
2014
Although evidence indicates that estrogen replacement therapy reduces risk of coronary heart disease, the mechanism remains unknown. Among possibilities are may 1) inhibit growth atherosclerotic plaque and 2) decrease prevalence transient myocardial ischemia infarction by modulating vasomotion in arteries. Using quantitative angiography, we determined vasomotor responses arteries ovariectomized cynomolgus monkeys; six were given physiological "replacement" subcutaneous implants, not....
Objective— Some of the statin-induced reduction in cardiac events patients with atherosclerosis may be derived from mechanisms independent lipid lowering. This study tested nonhuman primates whether statins can influence inflammation (indicated by vascular cell adhesion molecule-1, interleukin-1β, tissue factor, and macrophages) features plaque stability collagen smooth muscle cells) their effect on plasma cholesterol level. Methods Results— Adult male cynomolgus monkeys (n=12 per group)...
Abstract The factors responsible for the marked gender differences in risk of coronary heart disease and atherosclerosis severity remain largely undetermined. While some clinical experimental evidence supports a protective effect endogenous estrogen on initiation progression incidence disease, much epidemiological data do not support this conclusion. possibility that androgens may have adverse effects has received little attention. We investigated experimentally induced hyperandrogenism...
Abstract The objective of this study was to determine the structural and functional changes that occur in artery wall response plasma lipid lowering hormone replacement surgically postmenopausal monkeys with established coronary atherosclerosis. Eighty-eight cynomolgus were fed an atherogenic diet for 24 months then allocated into 4 groups: group 1 (n=20), a baseline necropsy group; 2 (n=25), lipid-lowering only; 3 (n=22), plus conjugated equine estrogen treatment equivalent 0.625 mg/d...
Intravenous injection of an adeno-associated viral vector expressing the myotubularin ( MTM1 ) gene improves survival and rescues skeletal muscle function in mice dogs affected by myotubular myopathy.
Purpose An American Society of Clinical Oncology (ASCO) provisional clinical opinion (PCO) offers timely direction to the ASCO membership after publication or presentation potentially practice-changing data from major studies. This PCO addresses role prostate-specific antigen (PSA) testing in screening men for prostate cancer. Context Prostate cancer is second leading cause deaths among United States. The rationale potential reduce risk death through early detection. Recent Data Evidence a...
BACKGROUND Healthy arteries exhibit endothelium-dependent dilation in response to both local acetylcholine and increased blood flow. In humans, clinically overt coronary artery disease is characterized by loss of The temporal relation, however, between functional abnormalities the endothelium development atherosclerosis has not been established. METHODS AND RESULTS We examined endothelial vasodilator function vivo at an early stage atherosclerosis. Two groups seven Macaca fascicularis...
Neural phase signaling has gained attention as a putative coding mechanism through which the brain binds activity of neurons across distributed areas to generate thoughts, percepts, and behaviors. been shown play role in various cognitive processes, it suggested that altered may mediating deficits observed neuropsychiatric illness. Here, we investigated neural two mouse models dysfunction: mice with genetically induced hyperdopaminergia [dopamine transporter knock-out (DAT-KO) mice] NMDA...
Cell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinates of cell efficacy the different patient cohorts. We have reported that nonhuman primates chronicity ISD may affect but additional factors (age, psychosocial stress, hormone status, body weight) can be associated with many disease/treatment outcomes – these focus this study. Adult...
Hormone replacement therapy for postmenopausal women greatly reduces their risk of coronary heart disease. However, current pharmaceutical regimens have a low acceptance rate among women. We sought to identify an alternative treatment that would retain the beneficial health effects standard without its negative aspects. concentrated our research on naturally occurring estrogens (called phytoestrogens) found in soybeans, belief delivery phytoestrogens via diet be more acceptable than...
Abstract Animal models of arterial injury have failed to predict effective therapy prevent restenosis in humans. While this may relate species differences the control smooth muscle cell growth, many studies used nonatherosclerotic animals, thereby failing consider importance atherosclerosis response injury. In an attempt model human more accurately, we characterized angioplasty atherosclerotic monkeys. Twenty-one cynomolgus monkeys were fed atherogenic diet for 36 months (plasma cholesterol,...