A5101732275- Pregnancy and preeclampsia studies
- Gastroesophageal reflux and treatments
- Birth, Development, and Health
- Helicobacter pylori-related gastroenterology studies
- Bioactive Compounds and Antitumor Agents
- Prostate Cancer Treatment and Research
- Apelin-related biomedical research
- Single-cell and spatial transcriptomics
- Esophageal and GI Pathology
- Ginkgo biloba and Cashew Applications
- Hormonal and reproductive studies
- Liver physiology and pathology
- Ion Transport and Channel Regulation
- Maternal Mental Health During Pregnancy and Postpartum
- Folate and B Vitamins Research
- Prostate Cancer Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Treatment of Major Depression
- Effects and risks of endocrine disrupting chemicals
Jiangsu Provincial Center for Disease Control and Prevention
2018-2024
Nanjing Medical University
2020-2023
Nanjing Maternity and Child Health Care Hospital
2020-2021
Guangxi University
2017
Guangxi University of Chinese Medicine
2017
Stanford University
2007
Gestational diabetes mellitus (GDM) is associated with an increased risk of adverse pregnancy outcomes. Increasing evidence shows that placentation defects may play important roles in GDM. However, our understanding the human placenta remains limited. In this study, we generated a comprehensive transcriptomic profile cellular signatures and transcriptomes GDM using single-cell RNA sequencing (scRNA-seq), constructed cell atlas, identified subtypes subtype-specific marker genes. addition,...
Although the vital role of androgen receptor (AR) has been well demonstrated in primary prostate cancers, its androgen-insensitive cancers still remains unclear. Here, we used a small hairpin RNA approach to directly assess AR activity cancer cells. Reduction expression two androgen-sensitive cell lines, LNCaP and LAPC4, significantly decreased AR-mediated transcription growth. Intriguingly, LNCaP-C42B4 CWR22Rv1, knockdown showed more pronounced effect on AR-induced growth than depletion....
Vonoprazan is a new potassium-competitive acid blocker to treat acid-related diseases. However, its safety during pregnancy unclear. The aim of the study was investigate potential reproductive toxicity on embryo-fetal development vonoprazan. acetate administered by intravenous injection pregnant rats (0, 2, 6 and 20 mg kg-1 day-1 ) rabbits 1.2, 3.6 12 organogenetic period (gestation day 6-15 [rats] 6-18 [rabbits]). Maternal endpoints were evaluated, together with effects fetal growth...
Critical roles for liver sinusoidal endothelial cells (LSECs) in fibrosis have been demonstrated, while little is known regarding the underlying molecular mechanisms of drugs delivered to LSECs. Our previous study revealed that plumbagin plays an antifibrotic role fibrosis. In this study, we investigated whether alleviates capillarization hepatic sinusoids by downregulating endothelin-1 (ET-1), vascular growth factor (VEGF), laminin (LN), and type IV collagen on leptin-stimulated We found...
The potential effects of dimethylaminoethyl ginkgolid B on pregnant dams and embryo-fetal development had been investigated in both Sprague-Dawley rats New Zealand white rabbits.
Abstract Introduction In this study, JJH201501 was examined for reproductive toxicity during the perinatal period to support its safety as a novel serotonergic agent (5‐HT) antidepressant. Pregnant Sprague–Dawley rats (F0, n = 24/group) were continuously exposed 0 (control), 6, 18, and 60 mg/kg body weight/day of by intragastric administration from gestation day 15 lactation 21. Methods During period, maternal evaluated based on clinical signs, weight, feed intake, delivery condition, litter...
Objective To study the expression changes of placental insulin-like growth factor Ⅰ and Ⅱ (IGF-Ⅰ IGF-Ⅰ) between pregnancies following in vitro fertilization embryo transfer (IVF-ET) those conceived spontaneously.Methods The placenta were collected from 49 cases after IVF-ET(case group) who normal (control group).The expressions IGF-Ⅰ IGF-Ⅱ mRNA detected by reverse transcription-polymeras chain reaction (RT-PCR).The levels protein determined immunohistochemistry.Results IGF 0.30 ±0.13 0.28...
Gestational diabetes mellitus (GDM) will bring the increased risk of adverse pregnancy outcomes. More and more evidence showed that placentation defects might play important role in GDM. However, it is still very limited our understanding human placenta. This study fiestly generated a comprehensive transcriptomic profile cellular signifures transcriptomes placenta GDM by single-cell RNA-sequencing (scRNA-seq), built cell atlas, exploded identities cell-type-specific marker genes. In...
The novel potassium competitive acid blocker, KFP-H008, developed to overcome the shortcomings of proton pump inhibitors. In this study, KFP-H008 was administered by oral gavage at doses 0 (control), 15, 45, and 150 mg/kg Sprague-Dawley rats (24 animals per sex group). Body weight, food consumption, mortality, sexual cycle, mating behavior, pregnancy, sperm motility, relative organ weights were evaluated. a concomitant toxicokinetic (TK) study (10 group), plasma TK parameters tissue...