A5047679847- Peripheral Artery Disease Management
- Diagnosis and Treatment of Venous Diseases
- Phagocytosis and Immune Regulation
- Cardiovascular Disease and Adiposity
- Aortic aneurysm repair treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Studies on Chitinases and Chitosanases
- Pulmonary Hypertension Research and Treatments
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diabetic Foot Ulcer Assessment and Management
- Venous Thromboembolism Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Galectins and Cancer Biology
- Lipoproteins and Cardiovascular Health
- Abdominal vascular conditions and treatments
- Cardiac Imaging and Diagnostics
- Acute Ischemic Stroke Management
- Angiogenesis and VEGF in Cancer
- Complement system in diseases
- Ocular Surface and Contact Lens
Massachusetts General Hospital
2022-2024
Harvard University
2018-2023
Boston Public Health Commission
2022
Beth Israel Deaconess Medical Center
2018-2022
Stanford University
2018-2021
Cardiovascular Institute of the South
2019-2021
Dartmouth College
2019
Dartmouth–Hitchcock Medical Center
2017
University of California, San Francisco
2015
Background: Varicose veins are a common problem with no approved medical therapies. Although it is believed that varicose vein pathogenesis multifactorial, there limited understanding of the genetic and environmental factors contribute to their formation. Large-scale studies risk for may highlight important aspects pathophysiology identify groups at increased disease. Methods: We applied machine learning agnostically search in 493 519 individuals UK Biobank. Predictors were further studied...
Atherosclerosis is the process underlying heart attack and stroke. Despite decades of research, its pathogenesis remains unclear. Dogma suggests that atherosclerotic plaques expand primarily via accumulation cholesterol inflammatory cells. However, recent evidence a substantial portion plaque may arise from subset "dedifferentiated" vascular smooth muscle cells (SMCs) which proliferate in clonal fashion. Herein we use multicolor lineage-tracing models to confirm mature SMC can give rise...
Abstract Aims Atherosclerotic cerebrovascular disease underlies the majority of ischaemic strokes and is a major cause death disability. While plaque burden predictor adverse outcomes, vulnerability increasingly recognized as driver lesion rupture risk for clinical events. Defining molecular regulators carotid instability could inform development new biomarkers and/or translational targets at-risk individuals. Methods results Using two independent human endarterectomy biobanks, we found that...
Background The promise of precision population health includes the ability to use robust patient data tailor prevention and care specific groups. Advanced analytics may allow for automated detection clinically informative subgroups that account clinical, genetic, environmental variability. This study sought evaluate whether unsupervised machine learning approaches could interpret heterogeneous missing clinical discover important coronary artery disease subgroups. Methods Results Genetic...
Vascular calcification is a pathologic response to mineral imbalances and prevalent in atherosclerosis, diabetes mellitus, chronic kidney disease. When located the media, it highly associated with increased cardiovascular morbidity mortality, particularly patients on dialysis. tightly regulated controlled by series of endogenous factors. In present study, we assess effects lysosomal endosomal inhibition vascular smooth muscle cells (VSMCs) aortic rings. We observed that function was VSMCs...
This study sought to determine whether 18F-fluorodeoxyglucose-positron emission tomography/computed tomography could be applied a murine model of advanced atherosclerotic plaque vulnerability detect response therapeutic intervention and changes in lesion stability. Approach Results: To analyze plaques susceptible rupture, we fed ApoE-/- mice high-fat diet induced vulnerable lesions by cast placement over the carotid artery. After 9 weeks treatment with orthogonal agents (including...
Cannabis criminalization disproportionately harms communities of color in the United States. In Massachusetts' legal recreational ("adult-use") cannabis industry, state regulations intend to promote diverse participation. We assessed short-term racial/ethnic and gender diversity across industry senior-level positions with greater opportunities build wealth (i.e., board members, executives, directors).We extracted race/ethnicity from required registration forms submitted regulators for each...
Background: Vascular calcification is prevalent in patients with atherosclerosis, chronic kidney disease (CKD), diabetes, and peripheral artery (PAD). When located the arterial media, it strongly associated increased cardiovascular morbidity mortality. The cyclic nucleotides cAMP cGMP play important regulatory roles a variety of human diseases that are controlled by distinct phosphodiesterase (PDE) isozymes. We have recently found PDE10A most highly induced isoform rodent model...
Background and Aims: Peripheral artery disease (PAD) is a heritable atherosclerotic condition that underdiagnosed undertreated. With growing knowledge of the genetic basis for PAD related risk factors, this study sought to construct new polygenic score (GPS ). Methods: GPS was constructed by integrating multi-ancestry summary statistics traits. trained in UK Biobank dataset 96,239 individuals validated holdout (N=304,294) All Us (AoU; N=237,173) Mass General Brigham (MGBB, N=37,017)....
Background: Peripheral artery disease (PAD) is a heritable atherosclerotic condition. With growing knowledge of the genetic basis for PAD and related risk factors, there opportunity to identify high-risk individuals prevention potentially intervention based on polygenic background. Aims: To develop validate an integrated genome-wide score (GPS ), evaluate association with major adverse limb events (MALE), compare predictive performance in diverse ancestral populations previously published...
Heparin Induced Thrombocytopenia (HIT) is a well-recognized phenomenon in patients receiving heparin. Scoring systems such as the 4T score along with platelet factor 4 (PF4) testing have improved recognition and clinical improvement typically observed soon after diagnosis made, heparin administration ceased, non-heparin anticoagulation initiated. We report case of HIT that was refractory to medical management setting recent fenestrated endovascular aneurysm repair which involved...
Background: Despite some shared risk factors, aortic aneurysms and atherosclerosis manifest differently across the aorta. While commonly co-exists with descending abdominal aneurysms, observations suggested a decreased of in patients ascending aneurysms. This has led to suggestion that drivers may be anti-atherogenic. Aim: Using carotid intima-media thickness (cIMT) as surrogate for deep learning-derived estimates diameter, this study examines whether are protective against longitudinal...
Infectious aortitis is an uncommon vascular pathology that can be associated with development of pseudoaneurysms and mycotic aneurysms the thoracic or abdominal aorta. Non-typhoidal Salmonellae most commonly cause gastroenteritis in adults rarely lead to infectious aortitis. In this report, we describe case a patient who presented fevers back pain underwent treatment Salmonella-associated pseudoaneurysm infrarenal aorta open situ reconstruction.
Moderate-intensity exercise increases measures of cognitive performance such as working memory and flexibility. Hyperthermia can result in declines through reduced motor function response inhibition. However, these results have been observed during the heat while core temperatures remain elevated. Heat therapy may promote improvements after treatment similar to training by inducing a stress-related response. PURPOSE: To compare immediately following one hour moderate-intensity aerobic or...