A5067561635- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Diversity and Career in Medicine
- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Pharmaceutical industry and healthcare
- Biomedical Ethics and Regulation
- Acute Ischemic Stroke Management
- Surgical Simulation and Training
- Aortic Disease and Treatment Approaches
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 and healthcare impacts
- Innovations in Medical Education
- Hospital Admissions and Outcomes
- COVID-19 and Mental Health
- Ethics in Clinical Research
- Acute Kidney Injury Research
- Cardiovascular Health and Disease Prevention
- Enhanced Recovery After Surgery
- Infectious Aortic and Vascular Conditions
Massachusetts General Hospital
2021-2025
Harvard University
2021-2025
University of Michigan–Ann Arbor
2019-2023
Center for Discovery
2022
American College of Surgeons
2022
University of Pennsylvania
2020-2022
Center for Cancer Research
2022
Philadelphia VA Medical Center
2020-2022
Frederick National Laboratory for Cancer Research
2022
National Cancer Institute
2022
In the unprecedented disruption and social isolation of COVID-19 pandemic, families around world are faced with questions how their children can thrive in these conditions. On top ubiquitous challenges for all children, this public health crisis imparts unique difficulties special needs. We identify Autism Spectrum Disorder (ASD) as being particularly vulnerable to negative impacts pandemic. paper, we examine why ASD uniquely vulnerable, recommend strategies mitigate stressors parents,...
Female underrepresentation in oncology clinical trials can result outcome disparities. We evaluated female participant representation US by intervention type, cancer site, and funding.Data were extracted from the publicly available Aggregate Analysis of ClinicalTrials.gov database. Initially, 270,172 studies identified. Following exclusion using Medical Subject Heading terms, manual review, those with incomplete status, non-US location, sex-specific organ cancers, or lacking sex data, 1650...
Numerous candidate biomarkers in urine extracellular vesicles (EVs) have been described for kidney diseases, but none are yet clinical use, possibly due to a lack of proper normalization. Proper normalization corrects normal biological variation flow rate or concentration, which can vary by over one order magnitude. Here, we observed inter- and intra-animal excretion rates small EVs (<200 nm diameter) healthy rats as series six 4-h fractions. To visualize variation, normalized EV peak rate,...
Background Peripheral artery disease is endemic in our globally aging population, with >200 million affected worldwide. Graft/stent thrombosis after revascularization common and frequently results amputation, major adverse cardiovascular events, mortality. Optimizing medications to decrease of paramount importance; however, limited guidance exists on how use monitor antithrombotic therapy this heterogeneous population. Thromboelastography platelet mapping (TEG‐PM) provides comprehensive...
Background Antiplatelet therapy is used to prevent thrombosis in patients with peripheral artery disease (PAD) following revascularization. However, the current standard of care for these remains at physician’s discretion, varying from mono-antiplatelet (MAPT) dual-antiplatelet (DAPT). Viscoelastic assays such as Thromboelastography Platelet Mapping (TEG-PM) provide insight into individual coagulation profiles and measure real-time platelet function. This prospective, observational study...
Glycosylation is a vital post-translational modification involved in range of biological processes including protein folding, signaling, and cell-cell interactions. In 2011, new type O-linked glycosylation was discovered, wherein the side-chain oxygen tyrosine modified with GalNAc residue (GalNAc-Tyr). At present, very little known about GalNAc-Tyr prevalence, function, or biosynthesis. Herein, we describe design synthesis GalNAc-Tyr-derived hapten its use generating selective monoclonal...
Objectives: Quantitative sensory testing may help predict treatment responses in individuals with chronic pain. Our objective was to determine whether evoked pain sensitivity at baseline predicted preferential either emotional awareness and expression therapy (EAET) or cognitive behavioral (CBT) fibromyalgia (FM). Methods: This a secondary analysis of previous randomized clinical trial, which FM were EAET, CBT, Education as control intervention. Only females who completed post-treatment...
To adjust for dynamic insulin requirements in critically ill patients, intravenous (IV) infusions allow titration of the dose according to a prespecified algorithm. Despite adaptability IV protocols, human involvement calculation allows error. We integrated previously validated calculator into our electronic health record (Epic) and instituted it cardiovascular intensive care unit (CVICU). aim describe design calculator, implementation process, evaluate calculator's impact.Employing an...
Surgical residency programs have experienced a shift in resident procedural experience due to technologic advancements and work hour restrictions, making it imperative maximize learning from each operative case. Studies on surgeon perspective identified "coming prepared operate" "knowing what comes next" as the most important principles trainee can learn. However, way which case is performed varies by attending preference, institutional resources, regional variability. Literature has shown...
Objective: The objective of this study was to identify clinical and anatomic characteristics Popliteal artery aneurysms (PAAs) associated with acutely limb threatening events. Summary Background Data: are high morbidity mortality. Current guidelines recommend operative repair for PAAs a diameter greater than 20 mm based on very limited evidence. Methods: This retrospective cross-sectional cohort derived from multi-institutional database queried all patients PAA 2008 2022. Duplex ultrasound...
Exertional leg pain occurs with notable frequency among athletes and poses diagnostic challenges to clinicians due overlapping symptomatology. In this case report, we delineate the clinical presentation of a young collegiate soccer player who endured two years progressive bilateral exertional calf ankle weakness during athletic activity. The initial assessment yielded diagnosis chronic compartment syndrome (CECS), predicated on results testing. However, her was suspicious for concurrent type...
Clotting, anticoagulation, platelet consumption, and poor function are major factors in clinical extracorporeal circulation (ECC). We have shown that nitric oxide-releasing (NOReL) coatings prevent thrombosis a rabbit model of ECC without systemic anticoagulation. Nitric prevents adhesion activation, resulting preserved count function. Previous work has activated platelets form platelet-derived microparticles (PMPs). These experiments were designed to determine if PMPs can identify during...