A5007045807- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- T-cell and B-cell Immunology
- Barrier Structure and Function Studies
- Neuropeptides and Animal Physiology
- Biomarkers in Disease Mechanisms
- Cell death mechanisms and regulation
- Sperm and Testicular Function
- Animal health and immunology
- Pregnancy and preeclampsia studies
- Chemokine receptors and signaling
- Reproductive Biology and Fertility
- Nutrition and Health Studies
- Immune Response and Inflammation
- Hypothalamic control of reproductive hormones
- Urological Disorders and Treatments
- Endometriosis Research and Treatment
- RNA Interference and Gene Delivery
Institute of Animal Reproduction and Food Research
2014-2024
Polish Academy of Sciences
2014-2024
Differences in structural and functional properties between oocytes cumulus cells (CCs) may cause low vitrification efficiency for cumulus–oocyte complexes (COCs). We have suggested that the disconnection of CCs order to further cryopreservation various ways will positively affect viability after thawing, while co-culture vitro contribute restoration lost intercellular gap junctions. This study aimed determine optimal method suspension mature GV level mRNA expression genes (GJA1, GJA4; BCL2,...
Endometritis is a common disease in animals, leading to disruption of reproductive processes and economic losses. Noradrenergic control prostaglandin (PG)I2 formation by inflamed endometrium unknown. We determined the involvement α1-, α2- β-adrenoreceptors (ARs) noradrenaline-influenced PGI synthase (PGIS) protein abundance PGI2 release from porcine (1) endometrial explants with Escherichia coli (E. coli)-induced inflammation vivo, (2) E. lipopolysaccharide (LPS)-treated epithelial cells....
Decidualisation of the endometrium is a key event in early pregnancy, which enables embryo implantation. Importantly, molecular processes impairing decidualisation obese mothers are yet to be characterised. We hypothesise that impaired mice mediated by upregulation leptin modulators, suppressor cytokine signalling 3 (SOCS3) and protein tyrosine phosphatase non-receptor type 2 (PTPN2), together with disruption progesterone (P4)-signal transducer activator transcription (STAT3) signalling....
Abstract The process of luteal regression is tightly regulated by the immune system and chemokines—small cytokines responsible mostly for activation migration cells. role chemokines in porcine corpus luteum (CL) function still not well understood. aim this study was to investigate expression profile distribution CC CL during natural oestrous cycle early pregnancy. Additionally, effect PGF2α on selected their luteotropic apoptotic influence cells were studied vitro. levels CCL2, CCL4, CCL5...
In the inflamed uterus, production and secretion of prostaglandins (PGs) noradrenergic innervation pattern are changed. Receptor-based control prostaglandin E2 (PGE2) by noradrenaline during uterine inflammation is unknown. The aim this study was to determine role α1-, α2- β-adrenoreceptors (ARs) in noradrenaline-influenced PG-endoperoxidase synthase-2 (PTGS-2) microsomal PTGE synthase-1 (mPTGES-1) protein levels pig endometrium, PGE2 from tissue. E. coli suspension (E. group) or saline (CON...
Intercellular communication is a critical process that ensures cooperation between distinct cell types at the embryo-maternal interface. Extracellular vesicles (EVs) are considered to be potent mediators of this by transferring biological information in their cargo (e.g., miRNAs) recipient cells. miRNAs small non-coding RNAs affect function and fate neighboring distant cells regulating gene expression. Focusing on maternal side dialog, we recently revealed impact embryonic signals, including...
Abstract Endometritis is the most common pathology in animals. However, context of an inflamed endometrium, alterations occur production prostaglandins (PG s) and noradrenergic innervation uterus, although precise relationship between noradrenaline (NA), adrenoreceptors (AR s), output PG F2α remains unclear. To clarify this issue, participation α1-, α2- β-AR s NA-influenced F synthase FS) 9-ketoreductase/carbonyl reductase (CBR1) protein abundances porcine secretion from tissue were...
Uterine inflammation is a common pathology in animals, leading to disturbances reproductive processes and reduced production profitability. Pituitary adenylate cyclase-activating peptide (PACAP) effects at the uterine level during are not known. In current study, we analyzed relative PACAP type 1 receptor (PAC1R) mRNA transcript protein abundances myometrium (MYO), as well s PAC1R involvement contractile function of inflamed pig uterus. To that end, E. coli suspension (E. group) or saline...
1. ABSTRACT Intercellular communication is a critical process that ensures cooperation between distinct cell types at the embryo–maternal interface. Extracellular vesicles (EVs) are considered to be potent mediators of this by transferring biological information in their cargo (e.g. miRNAs) recipient cells. miRNAs small non-coding RNAs affect function and fate neighboring distant cells regulating gene expression. Focusing on maternal side dialog, we recently revealed impact embryonic...