A5013772324- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
- Natural Compounds in Disease Treatment
- Bioactive Compounds and Antitumor Agents
- Plant Toxicity and Pharmacological Properties
- Traditional and Medicinal Uses of Annonaceae
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Plant chemical constituents analysis
- Phytochemical compounds biological activities
- Ginseng Biological Effects and Applications
- PI3K/AKT/mTOR signaling in cancer
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Medicinal Plants
- Pharmacological Effects of Natural Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Bone Metabolism and Diseases
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Synthesis and Biological Activity
- Plant biochemistry and biosynthesis
- Crystallography and molecular interactions
Jiangxi University of Traditional Chinese Medicine
2014-2024
Tongji University
2022
University of North Texas
2021
University of North Texas Health Science Center
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2021
Weatherford College
2019
Northwestern Polytechnical University
2018
Xinjiang Institute of Materia Medica
2017
Peking Union Medical College Hospital
2017
State Council of the People's Republic of China
2017
Abstract Both human epidermal growth factor receptor 2 (HER-2/neu) and VEGF overexpression correlate with aggressive phenotypes decreased survival among breast cancer patients. Concordantly, the combination of trastuzumab (anti-HER2) bevacizumab (anti-VEGF) has shown promising results in preclinical xenograft studies clinical trials. However, despite known antiangiogenic mechanism anti-VEGF antibodies, relatively little is about their effects on pharmacokinetics tissue distribution other...
To evaluate the safety and immunogenicity of ZOSTAVAX administered concomitantly with inactivated influenza vaccine or sequentially in adults aged 50 older.Randomized, blinded, placebo-controlled study.Thirteen U.S. seven European study sites.Three hundred eighty-two concomitantly, 380 vaccinated subjects.The concomitant vaccination group received at separate injection sites on Day 1 placebo Week 4. The nonconcomitant 4.Primary endpoints: vaccine-related serious adverse experiences (AEs)...
B7-H4 has been implicated in cancers of the female reproductive system and investigated for its possible use as a biomarker cancer, but there are no preclinical studies to demonstrate that is molecular target therapeutic intervention cancer. We provide evidence prevalence expression levels high different subtypes breast cancer only few normal tissues express on cell membrane. These profiles low upregulation an opportunity antibody–drug conjugates (ADCs), cytotoxic drugs chemically linked...
Histone deacetylases (HDACs) engage in the regulation of various cellular processes by controlling global gene expression. The dysregulation HDACs leads to carcinogenesis, making ideal targets for cancer therapy. However, use HDAC inhibitors (HDACi) as single agents has been shown have limited success treating solid tumors clinical studies. This study aimed identify a novel downstream effector provide potential target combination therapy.Transcriptome sequencing and bioinformatics analysis...
Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo[5.3.1.01,5]undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), unprecedented 6/6/6/6 polycyclic skeleton, and C (3), novel terpenoid quinone C6–C3 unit, were isolated from the bark of Magnolia officinalis var. biloba. Plausible biogenetic pathways 1-3 are presented. Compounds 1 3 exhibited significant PTP1B inhibitory activities IC50 values 1.44 0.81 μM, respectively.
The belowground portion of extended pile-shaft-supported bridges is usually prone to earthquake-induced damage during earthquake shakings. unobservable pile below the ground surface makes it difficult and time-consuming estimate functionality loss these damaged decide whether reopen them for emergency traffic after an earthquake. Therefore, reliable rapid evaluation postearthquake vertical load-carrying capacity shafts essential recovery. To this end, one pile-shaft specimen in homogeneous...
Abstract Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total patients. In an attempt to develop a targeted therapeutic for this indication, we have identified and characterized Glial cell line–Derived Neurotrophic Factor (GDNF) Family Receptor Alpha 1 (GFRA1) antibody–drug conjugates (ADC) using cleavable valine-citrulline-MMAE (vcMMAE) linker-payload. RNAseq IHC analysis confirmed the abundant expression GFRA1 in luminal tissues, whereas minimal or no was observed...
Thirteen dihydroagarofuran derivatives, including 12 new sesquiterpenoid esters and one known alkaloid, were obtained from the leaves of Tripterygium wilfordii. Spectroscopic techniques ECD method used for structure elucidation compounds. The structures compounds 1 8 confirmed by single-crystal X-ray crystallographic analyses. Compounds 8, 9, 11, 12, 13 increased cell viability okadaic acid treated PC12 cells 60.4 ± 23.0% to 72.4 14.1, 71.5 11.5, 75.7 15.6, 81.2 13.1, 86.2 25.5% at 10 μM,...
Eight new alkaloid derivatives (<bold>1–5</bold>), including three pairs of enantiomers, were obtained from <italic>Clausena lansium</italic>, and showed moderate neuroprotective effects.
Three triterpene saponins, nototronesides A–C (1–3), possessing an unprecedented 6/6/9 fused tricyclic tetranordammarane core, were isolated from the leaves of Panax notoginseng. Their structures elucidated on basis spectroscopic data, and structure sapogenin (1a) was further confirmed by X-ray crystallography. The existence 1–3 adds a new dimension to diversity family. Moreover, compound 2 showed moderate neuroprotective effect serum deficiency-induced cellular damage in PC12 cells.
Phosphoinositide-3 kinase (PI3K) signaling pathway alterations occur broadly in cancer and PI3K is a promising therapeutic target.Here, we investigated acquired resistance to GDC-0941, inhibitor clinical trials.Colorectal (CRC) cells made be resistant GDC-0941 were discovered secrete amphiregulin, which resulted increased EGFR/MAPK signaling.Moreover, prolonged inhibition cultured over period of months led secondary loss PTEN 40% the CRC lines with inhibition.In absence inhibitor, these...
Three new C-methylated phenylpropanoid glycosides (1, 2), a 8–4′-oxyneolignan (3), together with two known analogs (4, 5), were isolated from the rhizomes of Imperata cylindrical Beauv. var. major (Nees) C. E. Hubb. Their structures determined by spectroscopic and chemical methods. Compounds 1, 2, 5 (10 μM) exhibited pronounced hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in vitro assays. Furthermore, their antioxidant activities...