A5052999418- Bone and Dental Protein Studies
- Endodontics and Root Canal Treatments
- Liver Disease Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Eicosanoids and Hypertension Pharmacology
- Oral microbiology and periodontitis research
- Peptidase Inhibition and Analysis
- Veterinary Equine Medical Research
- Proteoglycans and glycosaminoglycans research
- Renin-Angiotensin System Studies
- Protease and Inhibitor Mechanisms
- Alkaline Phosphatase Research Studies
- Bone Metabolism and Diseases
- Mast cells and histamine
- Nitric Oxide and Endothelin Effects
- Curcumin's Biomedical Applications
- Sperm and Testicular Function
- Oral and gingival health research
- Youth, Drugs, and Violence
- Antimicrobial Peptides and Activities
Universidade Estadual Paulista (Unesp)
2013-2023
Universidade Federal de São Paulo
2015-2018
Centro Universitário de Araraquara
2018
Abstract Background Cimetidine, histamine H 2 receptors antagonist, has caused adverse effects on the male hormones and reproductive tract due to its antiandrogenic effect. In testes, peritubular myoid cells muscle vascular death been associated seminiferous tubules testicular microvascularization damages, respectively. Either androgen or have detected in mucosa smooth muscular layer of vas deferens. Thus, effect cimetidine this histamine-dependent duct was morphologically evaluated. Methods...
The comprehension of dental pathogenesis and disorders derived from eruption failure requires a deep understanding the molecular mechanisms underlying normal tooth eruption. As intense remodelling is needed during eruption, we hypothesize that matrix metalloproteinase-1 (MMP-1) acid phosphatase (ACP) play role in eruptive pathway degradation. We evaluated MMP-1-immunoexpression collagen content lamina propria at different phases. Immunohistochemistry ultrastructural cytochemistry for...
Histamine seems to act, via H2 receptor, on inflammatory processes by stimulating interleukin (IL)-6 and matrix metalloproteinase (MMP) release. As cimetidine is an receptor antagonist, the authors hypothesize that this antiulcer drug reduces IL-6, MMP-1, MMP-9 immunoexpression in gingiva with induced periodontal disease (PD). To confirm a possible modulatory role of IL-6 MMPs, relationship between IL-6/MMP-1 IL-6/MMP-9 was evaluated.Forty-six male rats were distributed into group (CimG:...
Abstract During tooth eruption, structural and functional changes must occur in the lamina propria to establish eruptive pathway. In this study, we evaluate that during degradation focus these efforts on apoptosis microvascular density. Fragments of maxilla containing first molars from 9‐, 11‐, 13‐ 16‐day‐old rats were fixed, decalcified embedded paraffin. The immunohistochemical detection vascular endothelial growth factor (VEGF), caspase‐3 MAC 387 (macrophage marker), TUNEL method applied...
This study investigated whether osteocalcin (OCN) is present in osteoblast precursors and its relationship with initial phases of alveolar process formation. Samples maxillae 16-, 18-, 20-day-old rat embryos (E16, E18, E20, respectively), 05-, 10-, 15-day-old postnatal rats (P05, P10, P15, respectively) were fixed embedded paraffin or araldite. Immunohistochemistry for osterix (Osx), alkaline phosphatase (ALP), OCN detection was performed the number immunolabelled cells computed....
The aim of this study was to analyze the morphological aspects liver parenchyma components in three stages age Holtzman rats.The livers 33 female rats (Rattus norvegicus albinus, Holtzman) aged 120 days (G1 -young), 180 (G2 -adults) and 540 (G3 -elderly), with natural aging were studied.The material processed submitted picrosirius technique polarized light for visualization collagen fibers, Periodic Acid -Schiff Reactive (PAS) evidence glycogen stained nuclei search mucus substances.After...