A5082102866- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Cardiac pacing and defibrillation studies
- Inhalation and Respiratory Drug Delivery
- Heart Rate Variability and Autonomic Control
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Valve Diseases and Treatments
- Non-Invasive Vital Sign Monitoring
- Congenital Heart Disease Studies
- Cardiovascular and exercise physiology
- Cardiomyopathy and Myosin Studies
- Anesthesia and Sedative Agents
- Hydraulic and Pneumatic Systems
- Cardiac Arrhythmias and Treatments
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Cardiovascular Health and Disease Prevention
- Obstructive Sleep Apnea Research
Institute of Biocybernetics and Biomedical Engineering
2013-2025
Polish Academy of Sciences
2013-2025
Medical University of Warsaw
2010-2011
Istituto di Chimica Biomolecolare
2002
Institute of Biomedical Technologies
2002
Leeds General Infirmary
1996-1998
Boston Children's Hospital
1994
Boston Children's Museum
1994
Johns Hopkins University
1987-1989
Guy's Hospital
1986
The airway problems encountered during anaesthesia in all children with mucopolysaccharidoses presenting for a surgical procedure from 1988 to September 1991 are reviewed. Thirty-four patients underwent 89 anaesthetics 110 procedures. results reveal high incidence of problems. overall difficult intubation was 25% and failed 8%. In those Hurler's syndrome, the 54% 23%. Other potential anaesthetic such as cardiac anomalies obstructive sleep apnoea also
Lidocaine, a widely used local anaesthetic, also serves as an adjuvant in pain management. However, its use children is off-label. This study aimed to determine if intravenous lidocaine alleviates the haemodynamic, metabolic, and hormonal responses intubation laparoscopic surgery children. A single-centre, parallel, double-masked, randomised, placebo-controlled trial. 132 patients, aged 18 months years, with no contraindications administration qualified for appendectomy were enrolled. The...
Abstract Long‐term mechanical circulatory assistance opened new problems in ventricular assist device—patient interaction, especially relation to autonomic controls. Modeling studies, based on adequate models, could be a feasible approach of investigation. The aim this work is the exploitation hybrid (hydronumerical) cardiovascular simulator reproduce and analyze vivo experimental data acquired during continuous flow left assistance. embeds three submodels: computational submodel, baroreflex...
Abstract The paper presents a hybrid (hydro-numerical) circulatory model built to be used as complementary tool for clinical purposes. It was developed at the Institute of Biocybernetics and Biomedical Engineering - Polish Academy Sciences (Poland) in co-operation with Clinical Physiology National Council Research (Italy). Main advantages are: 1) high accuracy repeatability parameters setting, characteristic numerical solutions, 2) maximum flexibility achieved by implementing largest...
Mock circulatory systems are used to test mechanical assist devices and for training research purposes; when compared numerical models, however, they not flexible enough rather expensive. The concept of merging physical resulting in a hybrid one, is applied here represent the input impedance systemic arterial tree, by conventional windkessel model built out an electro-hydraulic (E-H) simulator added hydraulic section. This inserted into open loop circuit, completed another representing...
Merging numerical and physical models of the circulation makes it possible to develop a new class circulatory defined as hybrid. This solution reduces costs, enhances flexibility opens way many applications ranging from research education heart assist devices testing. In prototype described in this paper, hydraulic model systemic arterial tree is connected lumped parameters including pulmonary remaining parts circulation. The consists characteristic resistance, silicon rubber tube allow...
Background Due to economic and ethical problems, virtual organs may appear more convenient than experiments on animals or limited investigations patients. In particular, a respiratory system (VRS) be useful for tasks such as respirators support methods testing, education, staff (medical technical) training, (initial) testing of scientific hypotheses. Methods A comparative study simulated real spirometric results different patient states (healthy lungs, restrictive lung disease, obstructive...
The aim of this work is to study pediatric pneumatic ventricle (PVAD) performance, versus VAD rate (VADR) and native heart (HR) ratio Rr (VADR/HR). uses a hybrid model the cardiovascular system (HCS). HCS consists computational part (a lumped parameter including left right ventricles, systemic pulmonary arterial venous circulation) interfaced physical part. This permits connection (15 mL PVAD). Echocardiographic hemodynamic data patient (average weight 14.3 kg, HR 100 bpm, pressure 75/44 mm...
Experience with percutaneous dilatational tracheostomy in children is limited. This report discusses two significant complications which occurred following the use of this technique
Physical models of the circulation are used for research, training and testing implantable active passive circulatory prosthetic assistance devices. However, in comparison with numerical models, they rigid expensive. To overcome these limitations, we have developed a model based on merging lumped parameter physical into one (producing therefore hybrid). The is limited to barest essentials and, this application, test principle, it windkessel representing systemic arterial tree. parameters was...
Methacholine and citric acid responses were assessed before, during, after 6 wk of oral treatment with either placebo or methylprednisolone (2 mg.kg-1.day-1) in 12 Basenji-Greyhound dogs. Bronchoalveolar lavage was performed three dogs each group pretreatment. Base-line airway resistance dynamic compliance did not change any the groups. Placebo had no demonstrable effect on methacholine responsiveness. Methylprednisolone abolished constrictor response to during 4th 6th significantly reduced...
The analysis of energetic ventricular variable changes during artificial ventilation, obtained by numerical simulation was done. Twenty-one sets hemodynamic parameters for eight cardiosurgical patients were used to estimate left and right stroke work. data collected three methods ventilation: conventional, lung-protective (with minute ventilation diminished half) high frequency 5, 10, or 15 Hz).The computer simulator (CARDIOSIM) the cardiovascular system, as a tool calculate values variables...
Aim of this work is to study the impact left ventricular rotary blood pump assistance, on energetic variables, when mechanical ventilation (MV) lungs applied.Computer simulation was used perform study. Lumped parameter models reproduce circulatory system. Variable elastance Starling's law heart for each ventricle. After reproduction ischemic disease assistance applied using a model pump. The speed changed in steps and assumed be constant during step. influence introduced by different values...
Despite the significant technological progress achieved in past decades medical field, device-related infections carry a heavy social and economic burden. Surface modification of equipment is one most interesting approaches employed to improve antibacterial activity material. Herein, we developed process for gold nanoparticle poly(vinyl chloride) laryngeal tube, which typically serves as an airway management device. In our study, focused specifically on increasing antimicrobial properties...
Our aim was to study the feasibility of implanting Infant Jarvik 2015 in patients weighing less than 8 kg. The left ventricular assist device (LVAD) tested a hybrid simulator cardiovascular system reproducing specific patients' hemodynamics for different patient weights (2-7 kg). For each weight, sensitivity pump circulatory parameters (peripheral resistance, elastance, right heart rate, and filling characteristics) has been repeating experiment ramp (10 000-18 000 rpm). increase speed...
Computer simulation of a cardiovascular system enabled us to predict the effects simultaneous application mechanical ventilation (MV) and intraaortic ballon pumping (IABP) on ventricular energetics. External work (EW), pressure-volume area (PVA), potential energy (PE) cardiac efficiency (CME) were calculated. Nummerical showed that changes positive intrathoracic pressure have considerable effect left right EW, PE, PVA CME, whether IABP is used or not. The energetics was much less influenced...