A5032677400- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Fuel Cells and Related Materials
- Heart Rate Variability and Autonomic Control
- Advanced Chemical Sensor Technologies
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Analytical Chemistry and Sensors
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Cardiac pacing and defibrillation studies
- Advanced biosensing and bioanalysis techniques
- Congenital Heart Disease Studies
- Atherosclerosis and Cardiovascular Diseases
- Analytical Methods in Pharmaceuticals
- Non-Invasive Vital Sign Monitoring
- Advanced MRI Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Ultrasound and Hyperthermia Applications
University of Pisa
1986-2024
National Research Council
2015-2024
Flinders University
2024
Flinders Medical Centre
2024
Istituto di Fisiologia Clinica
2014-2023
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2020-2023
Czech Academy of Sciences, Institute of Physiology
1994-2017
National Academies of Sciences, Engineering, and Medicine
1996-2015
University of Miami
2015
Physiol (Belgium)
2011
Textile-based sensors offer an unobtrusive method of continually monitoring physiological parameters during daily activities. Chemical analysis body fluids, noninvasively, is a novel and exciting area personalized wearable healthcare systems. BIOTEX was EU-funded project that aimed to develop textile measure the chemical composition with particular interest in sweat. A sensing system has been developed integrates textile-based fluid handling for sample collection transport number including...
Wearable sensors present a new frontier in the development of monitoring techniques. They are great importance sectors such as sport and healthcare they enable physiological signals biological fluids, human sweat, to be continuously monitored. Until recently this could only carried out specialized laboratories using cumbersome often expensive devices. Sweat integrated onto textile substrates not innovative but also represent first attempt use an idea system that will worn directly on body....
Nalophan, Tedlar and Cali-5-Bond polymeric bags were compared to determine the most suitable type for breath sampling storage when volatile organic compounds are be determined. Analyses performed by thermal desorption gas chromatography mass spectrometry. For each bag, release of contaminants chemical stability a gaseous standard mixture containing eighteen compounds, as well CO2 partial pressure assessed. The selected representative constituents belonged different classes (i.e....
The analytical performances of needle trap micro-extraction (NTME) coupled with gas chromatography-tandem mass spectrometry were evaluated by analyzing a mixture twenty-two representative breath volatile organic compounds (VOCs) belonging to different chemical classes (i.e. hydrocarbons, ketones, aldehydes, aromatics and sulfurs). NTME is an emerging technique that guarantees detection limits in the pptv range pre-concentrating low volumes sample, it particularly suitable for analysis. For...
Sweat analysis can provide a valuable insight into person's well-being. Here we present wearable textile-based sensors that real-time information regarding sweat activity. A pH sensitive dye incorporated fabric fluidic system is used to determine pH. To detect the onset of
Background Patients on warfarin therapy undergo invasive and expensive checks for the coagulability of their blood. No information coagulation levels is currently available between two controls. Methodology A method was developed to determine in oral fluid by HPLC fluorimetric detection. The chromatographic separation performed at room temperature a C-18 reversed-phase column, 65% PBS 35% methanol mobile phase, flow rate 0.7 mL/min, injection volume 25 µL, excitation wavelength 310 nm,...
Abstract Heart failure (HF) is the main cause of mortality worldwide, particularly in elderly. N-terminal pro-brain natriuretic peptide (NT-proBNP) gold standard biomarker for HF diagnosis and therapy monitoring. It determined blood samples by immunochemical methods generally adopted most laboratories. Saliva analysis a powerful tool clinical applications, mainly due to its non-invasive less risky sampling. This study describes validated analytical procedure NT-proBNP determination saliva...
In 2019, the International Consortium for Personalised Medicine (ICPerMed) developed a vision on how use of personalized medicine (PM) approaches will promote "next-generation" in 2030 more firmly centered individual's personal characteristics, leading to improved health outcomes within sustainable healthcare systems through research, development, innovation, and implementation benefit patients, citizens, society. Nevertheless, there are significant hurdles that professionals, researchers,...
To investigate personality traits and sympatho-vagal modulation of heart rate variability (HRV) during acute myocardial infarction (AMI), assessing their relationships long-term prognostic value.Psychological 24 h HRV were prospectively investigated in 246 patients at discharge an AMI. Patients followed-up to 8 years for the occurrence cardiac death non-fatal reinfarction. Low coping anxiety associated with reduced characterized study population. At univariate analysis, low emotional...
Journal Article Opposite transmural gradients of coronary resistance and extravascular pressure in the working dog's heart Get access ANTONIO L'ABBATE, L'ABBATE * From Laboratory Clinical Physiology C.N.R. Istituto Patologia Medica I, University Pisa, Italy *Reprint requests to: Dr Antonio L'Abbate, Laboratorio di Fisiologia Clinica C.N.R., Via Savi, 8, 56100 Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar MARIO MARZILLI, MARZILLI A MARIA BALLESTRA,...
Mechanical unloading by left ventricular assist devices (LVADs) in advanced heart failure (HF), addition to improving symptoms and end-organ perfusion, is supposed stimulate cellular molecular responses which can reverse maladaptive cardiac remodeling. As microRNAs (miRNAs) are key regulators remodeling processes, a comparative miRNA profiling transplanted hearts of HF patients with/without LVAD assistance could aid comprehend underlying mechanisms. Next generation sequencing (NGS) was used...
The evolution of breath composition during oral glucose tolerance tests (OGTTs) was analysed by thermal desorption/gas chromatography/mass spectrometry in 16 subjects and correlated to blood levels. classified five the as diabetics, eight affected impaired three normoglycaemic. Acetone levels were generally higher diabetics (average concentration values: 300 ± 40 ppbv; tolerance, 350 30 normoglycaemic, 230 20 ppbv) but large inter-individual variability did not allow us identify groups this...
The artery medial layer is mainly composed of vascular smooth muscle cells (VSMCs). These contribute to the formation neointima and atherosclerotic plaques by switching from quiescent-contractile migratory-activated state. Apoptotic blebs, microvesicles exosomes are secreted vesicles, with differences in composition size, involved cellular communication at multiple levels. In this article, an untargeted, proteomics approach was exploited characterise VSMC released vesicles a preliminary...
The growing population of failing single-ventricle (SV) patients might benefit from ventricular assist device (VAD) support as a bridge to heart transplantation. However, the documented experience is limited isolated case reports. Considering complex and different physiopathology Norwood, Glenn, Fontan lack established experience, aim this work realize test lumped parameter model cardiovascular system able simulate SV hemodynamics VAD implantation effects clinical decision. Hemodynamic...
Scope Nonalcoholic fatty liver disease (NAFLD) is the most common with poor therapeutic strategies. Mastiha possesses antioxidant/anti‐inflammatory and lipid‐lowering properties. The authors investigate effectiveness of as a nonpharmacological intervention in NAFLD. Methods Results Ninety‐eight patients NAFLD three countries (Greece, Italy, Serbia) are randomly allocated to either or Placebo for 6 months, part multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group clinical...
Describes the development of a new microrobotic system for colonoscopy. The aim project is to design and fabricate miniature device colonoscopy which should provide same (or better) functions as conventional system, but much less pain discomfort patient. microrobot authors have fabricated tested able propel itself in colon semi-autonomous manner by inchworm locomotion obtained means pneumatic actuators controlled shape memory alloy (SMA) microvalves. microrobot, its propelling principle...