A5021675144- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- HIV/AIDS drug development and treatment
- Cardiac electrophysiology and arrhythmias
- HIV Research and Treatment
- Ion channel regulation and function
- HIV/AIDS Research and Interventions
- Anesthesia and Neurotoxicity Research
- Mesenchymal stem cell research
- European Socioeconomic and Political Studies
- Bone and Joint Diseases
- Hepatitis C virus research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Fibrosis and Remodeling
- Orthopedic Infections and Treatments
- Receptor Mechanisms and Signaling
- Parasitic Infections and Diagnostics
- HIV, Drug Use, Sexual Risk
- Amoebic Infections and Treatments
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Social Sciences and Governance
- Neuroscience of respiration and sleep
- Pharmacological Effects and Toxicity Studies
- Nicotinic Acetylcholine Receptors Study
Cliniques Universitaires Saint-Luc
1991-2025
Inserm
2005-2024
Université de Montpellier
2005-2024
Centre National de la Recherche Scientifique
2004-2024
Institut de Génomique Fonctionnelle
2009-2024
Kingston Health Sciences Centre
2022-2024
Laboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique
2017-2023
Université de Rouen Normandie
2020-2022
Maison des Sciences de l’Homme de Dijon
2021-2022
Kingston General Hospital
2021
Abstract Background The nature of multiple organ dysfunction syndrome (MODS) after traumatic injury is evolving as resuscitation practices advance and more patients survive their injuries to reach critical care. aim this study was characterize contemporary MODS subtypes in trauma care at a population level. Methods Adult admitted major centre units were enrolled 4-week point-prevalence study. defined by daily total Sequential Organ Failure Assessment (SOFA) score than 5. Hierarchical...
Background— Reperfusion during acute myocardial infarction remains the best treatment for reducing infarct size. Postconditioning, applied at onset of reperfusion, reduces both in animals and humans. The objective this study was to identify time delay apply postconditioning allowing preservation cardioprotection mouse myocardium. This is a major issue management patients. Methods Results— Mice were subjected 40 minutes ischemia 60 reperfusion (IR 60′ ). Postconditioning protocols...
An increase in circulating adrenal catecholamine levels constitutes one of the mechanisms whereby organisms cope with stress. Accordingly, stimulus-secretion coupling within stressed medullary tissue undergoes persistent remodeling. In particular, cholinergic synaptic neurotransmission between splanchnic nerve terminals and chromaffin cells is upregulated rats. Since transmission mainly supported by activation postsynaptic neuronal acetylcholine nicotinic receptors (nAChRs), we focused our...
Our objective was to determine the frequency and determinants of presentation care with advanced HIV disease in patients who discover their diagnosis at this stage as well those delayed after earlier stages. We collected data on 1,819 HIV-infected Brussels (Belgium) Northern France from January 1997 December 2007. "Advanced disease" defined CD4 count <200/mm3 or clinically-defined AIDS study inclusion stratified into two groups: (a) late testing, ≤6 months before initiation care; (b) care,...
Objectives We aimed to develop a guidance on the use of pre-exposure prophylaxis (PrEP) for HIV tailored Belgian context.
Intestinal parasitic diseases affect millions of people worldwide. Numerous commercial molecular methods detecting digestive parasites have been developed recently, including multiplex PCR assays able to identify multiple at once. Several studies demonstrated that the efficacy these is dependent on specific protocols employed each stage process pretreatment, extraction and amplification. However, previous exclusively focused one steps, without considering others. The objective present study...
Dolutegravir treatment can lead to neuropsychiatric adverse events (NPAE). This study assessed the association between NPAE and polymorphisms in dolutegravir-related pharmacogenes, determined by next-generation sequencing panel testing. Using a case-control design, 36 patients having previously discontinued dolutegravir due were compared 98 tolerating dolutegravir. In latter group, psychometric scores according genotype, targeting associated with drug intolerance. NR1I2 c.-22-7659C>T was...
Aims Grapefruit juice increases blood concentrations of many drugs metabolized by CYP3A. Amiodarone is CYP3A to N ‐desethylamiodarone (N‐DEA). The aim this study was determine amiodarone kinetics when administrated with and without grapefruit juice. Methods Eleven healthy adult volunteers took part in a single sequence, repeated‐measures design study. Each subject, who had been evaluated 6 months previously for pharmacokinetics, given oral dose (17 mg kg −1 ) three glasses 300 ml on the same...
Nowadays, many commercial kits allow the detection of
Measurement of quadriceps muscular force is recommended in individuals with COPD, notably during a pulmonary rehabilitation program (PRP). However, the tools used to measure maximal voluntary contraction (QMVC) and clinical relevance results, as well their interpretation for given patient, remain matter debate. The objective this study was estimate minimally important difference (MID) QMVC using fixed dynamometer COPD undergoing PRP.Individuals PRP were included study. measured (MicroFET2)...
Abstract Whole‐cell recordings in brainstem slices revealed postnatal changes passive and firing properties the rat caudal nucleus tractus solitarii (cNTS) neurons. Membrane potential, threshold for Na + spike degree of sag were unchanged during development. In adult, rheobase was twice that found at birth. The input resistance decreased over period studied, while time constants declined markedly after third week. At all ages, ‐dependent action potentials (APs) elicited response to...
Abstract Introduction In Belgium, oral HIV pre‐exposure prophylaxis (PrEP) is primarily provided in specialized clinical settings. Optimal implementation of PrEP services can help to substantially reduce transmission. However, insights into processes, and their complex interactions with local context, are limited. This study examined factors that influence providers’ adaptive responses the Belgian clinics. Methods We conducted a qualitative multiple case on care eight Thirty‐six...
Purpose Quality of life is a key element in the follow-up people living with HIV/AIDS. The main purpose this study was to validate French version WHOQOL-HIV instrument by comparing generic questionnaire. second objective test reproducibility Method and SF-36 questionnaires were filled out 50 patients on two separate occasions time interval 2 weeks. internal consistency, validity reliability evaluated. Results consistency acceptable for different domains, Cronbach's alpha ranging from 0.937...
Mesenchymal Stromal Cells (MSC) have been widely used for their therapeutic properties in many clinical applications including myocardial infarction. Despite promising preclinical results and evidences of safety efficacy phases I/ II, inconsistencies phase III trials reported. In a previous study, we shown using MSC derived from the bone marrow PPARβ/δ (Peroxisome proliferator-activated receptors β/δ) knockout mice that acute cardioprotective during first hour reperfusion are...
This study examined the interrater and test-retest reliability of qualitative scoring indices for Ruff Figural Fluency Test (RFFT) in a sample (N=90) healthy college undergraduates. In addition to rotational enumerative strategies proposed by, other supplemental were developed examined. Seven raters scored protocols independently using guidelines by additional examples primary investigator. Intraclass correlation coefficients (ICCs) excellent, ranging from r(ICC)=.91 number strategic...
Regulated cell death is a main contributor of myocardial ischaemia-reperfusion (IR) injury during acute infarction. In this context, targeting apoptosis could be potent therapeutical strategy. previous study, we showed that DAXX (death-associated protein) was essential for transducing the FAS-dependent apoptotic signal IR injury. The present study aims at evaluating cardioprotective effects synthetic peptide inhibiting FAS:DAXX interaction.An interfering engineered and then coupled to Tat...
Abstract Sinus node (SAN) dysfunction (SND) manifests as low heart rate (HR) and is often accompanied by atrial tachycardia or atrioventricular (AV) block. The only currently available therapy for chronic SND the implantation of an electronic pacemaker. Because growing burden in population, new pharmacological therapies block are desirable. We developed a collection genetically modified mouse strains recapitulating human primary associated with different degrees AV These mice were generated...