A5086997920- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- Genetic Neurodegenerative Diseases
- Rheumatoid Arthritis Research and Therapies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- Peripheral Neuropathies and Disorders
- HIV Research and Treatment
- Respiratory viral infections research
- Eosinophilic Disorders and Syndromes
- Multiple Sclerosis Research Studies
- Tuberculosis Research and Epidemiology
- Hereditary Neurological Disorders
- Immune Response and Inflammation
- Dermatological and COVID-19 studies
- Venous Thromboembolism Diagnosis and Management
- Nutrition and Health in Aging
- Hepatitis B Virus Studies
- Health, psychology, and well-being
Riga Stradiņš University
2012-2024
Czech Academy of Sciences, Institute of Microbiology
2016-2021
Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifactorial disease with an unexplained aetiology in which viral infections are possible trigger factors. The aim of this study was to determine the involvement human herpesvirus (HHV)-6A/B, HHV-7, and parvovirus B19 (B19V) etiopathogenesis ME/CFS. Methods 200 patients clinically diagnosed ME/CFS 150 apparently healthy individuals were enrolled study. Single-round, nested, quantitative real-time...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease that mainly diagnosed based on its clinical symptoms. Biomarkers could facilitate the diagnosis of ME/CFS are not yet available; therefore, reliable and clinically useful indicators high importance. The aim this work was to analyze association between course severity, presence HHV-6A/B infection markers, plasma levels autoantibodies against adrenergic muscarinic acetylcholine receptors. A total 134 patients with...
Abstract The relationship between beta‐herpesviruses reactivation and the development of complications after autologous peripheral blood stem cell transplantation was investigated. Viral genomic sequences were detected by polymerase chain reaction, virus‐specific antibodies ELISA, human herpesvirus (HHV)‐6 variants restriction endonuclease analysis. Virus reactivation, serum levels tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, soluble IL‐2 receptor (sIL‐2R), IL‐2, IL‐4 compared...
: Microvascular flap surgery has become a routine option for defect correction. The role of von Willebrand factor antigen (VWF:Ag) in the pathophysiology complications is not fully understood. We aim to investigate predictive value VWF:Ag microvascular and explore relationship between chronic inflammation VWF:Ag.
Background and objectives: There is still an uncertainty regarding the clinical symptomatology diagnostic criteria in terms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), as different exist. Our aim to identify core symptoms ME/CFS outpatient setting Riga; distinguish patients with those fatigue; investigate patient thoughts on onset, symptoms, treatment effect ME/CFS. Materials methods: Total 65 Caucasian from ambulatory care were included study. Questionnaires, specialist...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multifactorial disease that causes increasing morbidity worldwide, and many individuals with ME/CFS symptoms remain undiagnosed due to the lack of diagnostic biomarkers. Its etiology still unknown, but evidence supports role herpesviruses (including HHV-6A HHV-6B) as potential triggers. Interestingly, infection by these viruses has been reported impact expression microRNAs (miRNAs), short non-coding RNA sequences which...
Background and objectives: Composition of the peripheral blood (PB) cell populations their activation state reflect immune status a patient. Rheumatoid arthritis (RA) is characterized by abnormal B- T-cell functions. The objective this study was to assess profiles PB mononuclear (PBMC) in patients with rheumatoid osteoarthritis (OA) comparison healthy control (HC) subjects order evaluate PBMC as potential diagnostic characteristic RA. second aim CCR1 CCR2 expression on lymphocytes correlate...
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition with no identified diagnostic biomarkers to date. Its prevalence as high 0.89% according metastudies, quarter of patients bed- or home-bound, which presents serious public health challenge. Investigations into the inflammation–immunity axis encouraged by links outbreaks and disease waves. Recently, research our group revealed that antibodies beta2-adrenergic (anti-β2AdR) muscarinic...
The high sequence variation of RNA viruses necessitates use degenerate primers and probes or multiple in molecular diagnostic assays. We showed previously that PCR amplification two rounds, first with long target-specific then short generic primers, followed by detection using probes, can tolerate variation. Here we demonstrate up to 56 nucleotides also be applied real-time for the norovirus genogroup II improved sensitivity. Probe design (method incorporating quenchers, Zen internal...
Reliable serum biomarkers are of immense need for diagnostic purposes myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-a disabling and complex disease which diagnosis is mainly based on clinical symptoms. The aim this study was to evaluate a possible potential activin B by directly comparing 134 cases ME/CFS with 54 healthy controls. Analyses human level in plasma samples were performed using validated ELISA assay. results the show that levels did not differ statistically...
Background andObjectives: Viral infections are frequently cited as a major environmental factor implicated in thyroid gland diseases. This work aimed to estimate the presence of B19V infection patients with disorders. Materials and Methods: Thyroid tissue blood samples 50 autoimmune diseases (AITDs), 76 non-autoimmune (non-AITDs), 35 deceased subjects whose histories did not show any or (control group) were enrolled study. Virus-specific IgM IgG detected using ELISA, viral load PCRs....
Forecasting the progression of disease in early inflammatory stage most prevalent type multiple sclerosis (MS), referred to as relapsing-remitting (RRMS), is essential for making prompt treatment modifications, aimed reduce clinical relapses and disability. In total, 58 patients with RRMS, having an Expanded Disability Status Scale (EDSS) score less than 4, were included this study. Baseline magnetic resonance imaging (MRI) was performed, brain spinal cord lesions evaluated. The disability...
Fibromyalgia (FM) is a chronic disorder characterized by widespread musculoskeletal pain often accompanied fatigue, sleep disturbances, memory issues, and mood disorders. The exact cause of FM remains unknown, diagnosis typically based on history persistent pain, as there are no objective biomarkers usable in this available. aim study was to identify measurable indicators specific with potential biomarkers. This included 17 individuals diagnosed 24 apparently healthy persons. Using real-time...
Abstract Human bocavirus 1 (HBoV1) is a parvovirus recently found to be possible aetiologic agent of acute respiratory disease in children. We conducted the first clinical and molecular study on this virus Latvia (LV) Lithuania (LT). The aim was determine occurrence HBoV1 tract samples taken from hospitalised children with infections LV LT. In total 186 age one 50 months, who fulfilled criteria infection, including lower infections, or without fever, were included study. A nasopharyngeal...
Human herpesviruses (HHV)-6A, HHV-6B and HHV-7 are considered to be involved in the pathogenesis of epilepsy, a common neurological disorder. The objective this study was determine association roseoloviruses infection with epilepsy.53 epilepsy patients 104 ordinary blood donors were analyzed presence virus-specific antibodies by enzyme-linked immunosorbent assay (ELISA) immunofluorescence (IFA), genomic sequences, viral load gene expression polymerase chain reactions (PCRs) restriction...
Abstract Background The risk of developing severe and even fatal coronavirus disease 2019 (COVID-19) increases with various factors such as advanced age chronic diseases, especially those treated immunosuppressive drugs. Viral ribonucleic acid (RNA) viral load detection in extra-pulmonary specimens have been proposed to indicate severity. Case presentation Here we describe a COVID-19 case an 83-year-old Caucasian male patient underlying comorbidities, including cardiovascular autoimmune...
Abstract The functions of human natural killer cells are controlled by diverse families antigen receptors. Prominent among these the cell immunoglobulin-like receptors (KIR), a family genes clustered in one most variable regions genome — on chromosome 19q13.4. This study aimed to investigate possible interplay between KIR allotype, B19 infection, and thyroid disorders. Thyroid gland tissue 30 patients with autoimmune diseases (AITD), non-autoimmune (non-AITD) deceased subjects whose...
Abstract Patients with rheumatoid arthritis (RA) typically have many permanently inflamed joints. The inflammation inside the body can lead to general physical weakness, exhaustion, and drowsiness. This feeling of extreme tiredness is also called “fatigue”. Some people find this be worst symptom disease. However, clinical significance fatigue its pathogenesis not been recognised. study aimed determine development depending on activity aggressiveness RA. To achieve goal, patients were...