A5015649353- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Hepatitis Viruses Studies and Epidemiology
- Graphene and Nanomaterials Applications
- Cancer-related gene regulation
- Tuberculosis Research and Epidemiology
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- Fullerene Chemistry and Applications
- RNA regulation and disease
- COVID-19 diagnosis using AI
- Carbon Nanotubes in Composites
- Toxin Mechanisms and Immunotoxins
- Infectious Encephalopathies and Encephalitis
- Colorectal and Anal Carcinomas
- Extracellular vesicles in disease
- Renal Transplantation Outcomes and Treatments
- Bacteriophages and microbial interactions
Riga Stradiņš University
2012-2024
Czech Academy of Sciences, Institute of Microbiology
2010-2021
Latvian Biomedical Research and Study Centre
2018
Uppsala University
2016
The complexity of autoimmunity initiation has been the subject many studies. Both genetic and environmental factors are essential in development. Among others, include infectious agents. HHV-6 is a ubiquitous human pathogen with high global prevalence. It several properties suggestive its contribution to broad cell tropism, ability establish latency subsequent reactivation persistence, range immunomodulation capabilities. Studies have implicated plethora autoimmune diseases—endocrine,...
Virus-associated chronic inflammation may contribute to autoimmunity in a number of diseases. In the brain, autoimmune encephalitis appears related fluctuating reactivation states neurotropic viruses. addition, viral miRNAs and proteins can be transmitted via exosomes, which constitute novel but highly relevant mediators cellular communication. The current study questioned role HSV-1-encoded host-derived cerebrospinal fluid (CSF)-derived enriched from stress-induced neuroinflammatory...
The role of HPV in the survival prognosis patients with head and neck squamous cell carcinoma, especially laryngeal carcinoma (LSCC) hypopharyngeal (HPSCC), is still somewhat ambiguous. present study aimed to explore significance tumor suppressor proteins HPV16 E6 E7 oncoproteins assessment oropharyngeal (OPSCC), LSCC, HPSCC associated high-risk (HR-) low-risk (LR-) infections. By utilizing molecular immunohistochemical investigations HNSCC samples patient data, univariate multivariate...
Background. Liposomal magnetofection is based on the use of superparamagnetic particles and cationic lipids shows better transfection efficiency than other common nonviral gene delivery methods; however, distribution aggregate complexes over cell surface may be ununiform. The a dynamic gradient magnetic field could overcome this limitation. A newly developed device for under was used to compare prostate carcinoma line PC3 with that obtained by lipofection magnetofection. Material Methods....
Antibodies to microbes, or autoantigens, are important markers of disease. Antibody detection (serology) can reveal both past and recent infections. There is a great need for development rational ways detecting quantifying antibodies, humans animals. Traditionally, serology using synthetic antigens covers linear epitopes up 30 amino acid peptides.We here report that peptides 100 acids longer ("megapeptides"), designed synthesized optimal serological performance, successfully be used as in...
Human papillomavirus (HPV) was proven to play a significant role in cancer development the oropharynx. However, its of laryngeal (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC) remains be clarified. High-risk HPV (HR-HPV) viral proteins E6 E7 are considered pertinent HPV-related carcinogenesis. Hence, our aim estimate LSCC HPSCC for HR-HPV DNA, p16, E6/E7 oncoprotein status by using molecular virology immunohistochemistry methods. The prevalence HPV16 infection 22/41 (53.7%) 20/31...
The aim of this study was to investigate the role human herpesvirus-6 (HHV-6) in autoimmune thyroiditis (AIT) development. We examined possible involvement HHV-6 gene expression encoding immunomodulating proteins U12 and U51 AIT development their modulation chemokine signaling. One hundred patients with following thyroidectomy were enrolled study. Nested polymerase chain reaction (nPCR) used detect sequence DNA samples. Reverse transcription PCR (RT-PCR) three different targets (U79/80, U12)...
Objectives. Most of human papillomavirus (HPV) infections are “cleared” by the immune system; however, in cases system suppression, could lead to development malignancies. The aim this study was find out frequency HR-HPV infection early period after renal transplantation recipients receiving immunosuppressive therapy and follow progression up one year. Methods. 43 female transplant 79 healthy individuals as a control group were enrolled investigation. For detection HPV infection, patients’...
Human herpesvirus-6 (HHV-6) contains two genes (U12 and U51) that encode putative homologues of human G-protein-coupled receptors like CCR1, CCR3, CCR5. It has been shown these viral proteins can be expressed on the surface epithelial some peripheral blood mononuclear cells, suggesting they could potentially induce autoimmunity. We aimed to investigate possibility HHV-6 encoded chemokine involvement in autoimmune thyroiditis (AIT) development by detecting peptide specific antibodies AIT...
The novel coronavirus SARS-CoV-2 poses a great public health crisis.As of December 2019, it has spread all over the world with cases reported in more than 100 countries and number infected individuals surpassing 1,000,000.On March 11 World Health Organization officially characterized COVID-19 as pandemic.Although genetic analysis revealed some similarities between causative agent 2002 SARS epidemic, both viruses have significant differences.Research done on SARS-CoV greatly aided...
Laryngeal papillomatosis (LP) is the most common benign laryngeal tumor in children, but it can affect both children and adults. Although benign, this condition still remains hard to treat negatively affects patient quality of life as spread adjacent respiratory tract, recurs, requires repeated medical intervention. As surgical removal papillomas with preservation normal mucosa only standard care, there no for adjuvant therapy. In case report, we describe course recurrent a Caucasian male...
OBJECTIVES: Most of human papilomavirus (HPV) infections are “cleared” by the immune system, however, in cases system suppression could lead to development malignancies. The aim this study was find out frequency HR-HPV infection early period after renal transplantation Latvian recipients receiving immunosuppressive therapy and follow progression up one year. 
 METHODS: 43 female (median age 48 IQR= 39-58) 79 practically healthy individuals 42-57) as a control group were enrolled...
Human papillomavirus type 18 is the second most common cause of cervical cancer and found in 7 to 20 % cases cancer. The oncogenic potential high-risk human associated with expression early proteins E6 E7. Due long-term immunosuppressive therapy, renal transplant recipients have a higher risk developing persistent infection. A 29-year-old white woman from Latvia chronic focal segmental glomerulosclerosis received allograft transplantation was prescribed therapy cyclosporine, prednisolone,...
Abstract The incidence of hypopharyngeal cancer globally is about 0.8 per 100 000. Globally, approximately 38 000 cases head and neck are considered yearly to be high-risk human papillomavirus (HR-HPV) related. Biopsy material fixation in formalin embedding paraffin (FFPE) creates many challenges. extraction nucleic acid requires a more complicated approach, often the extracted DNA fragmented. aim study was compare several HR-HPV detection methods from FFPE samples. analysed with different...
OBJECTIVES: Most of human papilomavirus (HPV) infections are “cleared” by the immune system, however, in cases system suppression could lead to development malignancies. The aim this study was find out frequency HR-HPV infection early period after renal transplantation Latvian recipients receiving immunosuppressive therapy and follow progression up one year. METHODS: 43 female (median age 48 IQR= 39-58) 79 practically healthy individuals 42-57) as a control group were...
Abstract Background The risk of developing severe and even fatal coronavirus disease 2019 (COVID-19) increases with various factors such as advanced age chronic diseases, especially those treated immunosuppressive drugs. Viral ribonucleic acid (RNA) viral load detection in extra-pulmonary specimens have been proposed to indicate severity. Case presentation Here we describe a COVID-19 case an 83-year-old Caucasian male patient underlying comorbidities, including cardiovascular autoimmune...
Abstract Kidney transplant recipients have higher incidence of human papillomavirus (HPV)-related malignancies, but studies on the natural history HPV infection are insufficient, especially regarding in male recipients. The aim this study was to evaluate course high-risk (HR-HPV) after kidney allograft transplantation recipients: estimate frequency and activity HR-HPV under immune system suppression. Twenty renal (age 20 - 68) were enrolled investigation examined dynamics. Peripheral...
Abstract The aim of this study was to investigate the possibility using monocytes/macrophages as mediators in human herpesvirus-6 (HHV-6) infection thyroid gland tissues autoimmune thyroiditis (AIT). Seventy-three AIT patients were enrolled study. control group consisted 80 blood donors. Monocyte/macrophage isolation for patient samples performed by adherence. HHV-6 detected peripheral mononuclear cell (PBMC) DNA nested polymerase chain reaction (nPCR). Gene expression active marker (U79/80)...