A5062298421- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Dermatology and Skin Diseases
- NF-κB Signaling Pathways
- Autoimmune Bullous Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory mediators and NSAID effects
- Biosimilars and Bioanalytical Methods
- Autoimmune and Inflammatory Disorders Research
- Immune Response and Inflammation
- Infrared Thermography in Medicine
- Antifungal resistance and susceptibility
- Viral Infections and Vectors
- Melanoma and MAPK Pathways
- Pharmaceutical studies and practices
- Ovarian function and disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Skin Protection and Aging
- Circular RNAs in diseases
- AI in cancer detection
- Protein Kinase Regulation and GTPase Signaling
- thermodynamics and calorimetric analyses
- Immunodeficiency and Autoimmune Disorders
Aarhus University Hospital
2015-2025
Aarhus University
2013-2025
Hospital Universitario 12 De Octubre
2024
World Health Organization - Denmark
2023
Technical University of Munich
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023
Fundación Instituto Valenciano de Oncología
2023
Aristotle University of Thessaloniki
2023
Hospital Infantil Universitario Niño Jesús
2023
Helsinki University Hospital
2023
Psoriasis is a common immune-mediated, chronic, inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes infiltration cells. Although TNFα- IL-17A-targeting drugs have recently proven to be highly effective, the molecular mechanism underlying pathogenesis psoriasis remains poorly understood. We found that expression atypical IκB member (inhibitor NF-κB) ζ, selective coactivator particular NF-κB target genes, was strongly increased in...
Biosimilars are designed to be analogous the biologic originators. However, comprehensive comparisons between biosimilars limited and lacking for patients with psoriasis. This study’s objective was compare 1-year drug survival of 2 adalimumab biosimilars, GP2017 SB5, following a non-medical mandatory switch from originator. Based on national clinical database DERMBIO, this nationwide cohort study included all psoriasis treated originator who underwent or SB5. The 525 switching 1 biosimilars:...
The JAK/STAT signaling pathway is suggested to play an important role in the pathogenesis of psoriasis, and recently inhibitors have shown promising results psoriasis treatment. present study aimed characterize STAT2 psoriasis. We demonstrated increased expression level phosphorylated/activated lesional compared with nonlesional psoriatic skin. Gene silencing by siRNA human keratinocytes revealed that upon IFNα stimulation CXCL11 CCL5 were only two cytokines, among 102 analyzed, found be...
Psoriasis is a common chronic inflammatory and immune-mediated skin disease. Antagonists of TNF-α and, recently, IL-17 have proven to be highly effective in the treatment for psoriasis; however, molecular mechanisms involved pathogenesis psoriasis are poorly understood. Recently, we presented evidence that IκBζ key regulator development through its role mediating IL-17A-driven effects. Like IL-17A, IL-17F produced by variety immune cells, expression increased psoriatic skin. The purpose this...
BackgroundIκBζ plays a key role in psoriasis by mediating IL-17A–driven effects, but the molecular mechanism which IL-17A regulates IκBζ expression is not clarified.ObjectiveWe sought to explore transformation patients with during anti-IL-17A (secukinumab) treatment focus on IκBζ.MethodsThe study was an open-label, single-arm, single-center secukinumab that included 14 plaque psoriasis. Skin biopsy specimens and blood samples were collected days 0, 4, 14, 42, 84 processed for microarray gene...
Secukinumab and Dead Sea treatment result in clear skin for many psoriasis patients, through distinct mechanisms. However, recurrence the same areas after treatments suggests existence of a molecular scar. We aimed to compare genetic differences patients who achieved complete response from secukinumab climatotherapy treatments. performed quantitative immunohistochemical transcriptomic analysis, addition digital spatial profiling punch biopsies. Histologically, both resulted normalization...
Identifying the optimal long-term biologic therapy for patients with psoriasis is often done through trial and error.To identify individual using predictive statistical machine learning models.This population-based cohort study used data from Danish nationwide registries, primarily DERMBIO, included adult treated moderate-to-severe biologics. Data were processed analyzed between spring 2021 2022.Patient clusters of clinical relevance identified their success rates estimated each drug....
Antagonists of IL-17A and its receptor have proven to be highly effective in the treatment psoriasis. However, many underlying molecular mechanisms involved pathogenesis psoriasis are still determined. IκBζ (encoded by NFKBIZ gene) plays a key role development mediating IL-17A- IL-17F-driven effects. Both IL-17F expression increased lesional psoriatic skin. IL-17A/A IL-17F/F homodimers as well IL-17A/F heterodimer signal through same receptors. The aim this study was characterize regulation...
Abstract: Mitogen‐ and stress‐activated protein kinase 1 2 (MSK1/2) are two kinases phosphorylated by both ERK1/2 p38 MAPK. Recently, MSK1 have been reported to act as negative regulators of acute inflammation. In this study, we investigated the role MSK1/2 in chronic skin inflammation using an oxazolone‐induced allergic contact dermatitis model knockout mice wild‐type mice. were demonstrated significantly increased compared with This was measured ear thickness, elevated infiltration...
To the Editor: Patients with and dermatologists treating psoriasis usually strive for complete skin clearance, yet some patients prefer being off treatment. However, prognosis after treatment discontinuation following remission is not well characterized. We investigated epidemiological characteristics disease markers during first 2 years cessation of biologics due to remission. DERMBIO contains detailed information on all Danish treated including cause discontinuation.1Egeberg A. Iversen L....
Abstract Background Interleukin (IL)-17A is a proinflammatory cytokine that plays an essential role in the development of psoriasis. Although treatment with anti-IL-17A monoclonal antibodies has demonstrated high efficacy patients psoriasis, not all respond equally well, highlighting need for biomarkers to predict response. Specific single-nucleotide polymorphisms (SNPs) genes encoding endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 ERAP2) have been associated psoriasis other...
Psoriasis is a common chronic inflammatory skin disease accompanied by heterogenous clinical and histological features, including characteristic keratinocyte hyperproliferation dermal immunogenic profile. In addition, psoriasis associated with widespread transcriptomic alterations changes in microRNA (miRNA) circular RNA (circRNA) abundance, which constitute non-coding (ncRNA) classes specific regulatory capacities diverse physiological pathological processes. However, the knowledge about...
Whether response to an interleukin (IL-17) inhibitor is different in patients with previous exposure IL-17 compared biologics other cytokine targets remains be elucidated. Therefore, the aim of this study was assess whether IL-17A associated worse than (an)other biologic(s). All DERMBIO register treated (secukinumab or ixekizumab) were included. With absolute Psoriasis Area and Severity Index (PASI) ≤ 2 as response, proportion responders inhibitors assessed previously another biologic(s),...
Biological therapies have established efficacy in psoriasis vulgaris. However, palmoplantar pustulosis (PPP) has proven difficult to treat, and data on drug survival these patients remain scarce.
Childhood psoriasis has a significant impact on the child´s quality of life and those who cannot be managed with topical treatment should considered for systemic treatment. The majority therapies used childhood are off-label drug therapies. Evidence-based studies scarce, algorithms generally based low-level evidence. A literature search was performed updated to October 2015 obtain an up date overview relevant in psoriasis. Methotrexate is conventional first-line treatment, but level evidence...
Interleukin (IL)-19 and IL-20 are important members of the IL-10 cytokine family, which known to play a role in inflammatory processes. Both anti-IL-19 -IL-20 targeting drugs have been suggested treatment diseases such as psoriasis rheumatoid arthritis. Recently, we presented I-kappa-B-zeta (IκBζ) key player by identifying IκBζ regulator IL-17/tumor necrosis factor (TNF)α-inducible psoriasis-associated genes proteins. Some these were synergistically regulated IL-17/TNFα.The purpose this...
Hirsutism is a widespread condition affecting 5%-15% of females. Laser treatment hirsutism has the best long-term effect. Patients with nonpigmented or nonterminal hairs are not eligible for laser treatment, and current patient journey needed to establish eligibility hair removal problematic in many health-care systems.