A5000799578- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Nutritional Studies and Diet
- Genomics, phytochemicals, and oxidative stress
- Sodium Intake and Health
- Phytochemicals and Antioxidant Activities
- Glutathione Transferases and Polymorphisms
- Polysaccharides Composition and Applications
- Garlic and Onion Studies
- Effects and risks of endocrine disrupting chemicals
- Iron Metabolism and Disorders
- Trace Elements in Health
- Renal function and acid-base balance
- Bariatric Surgery and Outcomes
- Polysaccharides and Plant Cell Walls
- Thermoregulation and physiological responses
- Phytoestrogen effects and research
- Chemical Analysis and Environmental Impact
- Contact Dermatitis and Allergies
- Pharmacogenetics and Drug Metabolism
- Food composition and properties
- Radioactivity and Radon Measurements
- Air Quality and Health Impacts
- Hemoglobinopathies and Related Disorders
- Chemical Safety and Risk Management
Federal Institute for Risk Assessment
2013-2019
Robert Koch Institute
2016-2018
University of Bonn
2016
Friedrich Schiller University Jena
2004-2010
Schiller International University
2005
The dietary exposure to selected PFAAs was estimated in four European states (Belgium, the Czech Republic, Italy and Norway) representing Western, Southern, Eastern Northern Europe. harmonised sampling programme designed Union project PERFOOD targeted at identifying seven PFAAs, including perfluorooctane sulfonic acid (PFOS) perfluorooctanoic (PFOA), food items that are most important both terms of consumption based on known high contamination patterns. average for adults (18-64 years)...
Diets rich in fruits and vegetables, like the Dietary Approaches to Stop Hypertension (DASH)-diet, are usually characterized by high potassium intake reduced dietary acid load, have been shown reduce blood pressure (BP). However, relevance of potential renal load (PRAL) for BP has not compared with urinary biomarker (K-urine)- food frequency questionnaire (K-FFQ)-based estimates a general adult population sample. For 6788 participants (aged 18-79 years) representative German Health-Interview...
Phenolic ingredients of an aqueous carob extract are well characterized and consist mainly gallic acid (GA). In order to assess possible chemopreventive mechanisms carob, which can be used as a cacao substitute, effects on expression genes related stress response drug metabolism were studied using human colon cell lines different transformation state (LT97 HT29). Stress-related genes, namely catalase (CAT) superoxide dismutase (SOD2), induced by GA in LT97 adenoma, but not HT29 carcinoma...
Apples contain significant amounts of flavonoids that are potentially cancer risk reducing by acting antioxidative or antiproliferative and favorably modulating gene expression. The purpose this study was to investigate whether polyphenols from apples modulate expression genes related colon prevention in preneoplastic cells derived adenoma (LT97). For this, LT97 were treated with effective concentrations apple extracts (AEs). RNA isolated used for synthesis labeling cDNA hybridized...
Abstract Apple extract (AE) enhances expression of glutathione S ‐transferases ( e.g ., GSTT2 ) in human colon cells (LT97). Therefore, aim the present study was to identify functional consequences induction by AE and determine relation effects isolated compounds. Polyphenol composition analyzed. LT97 were treated with or synthetic polyphenol mixture (SPM) under conditions that induced , challenged GSTT2‐2 substrate cumene hydroperoxide (CumOOH) DNA damage using comet assay. Modulation...
Ready-to-eat servings may be more contaminated with perfluorinated alkyl acids (PFAAs) than the corresponding unprocessed foods due to presence of PFAAs in and transfer from food contact materials (FCM) cookware. Therefore, selected meals served weekly at lunch time six Italian school canteens was assessed. Five towns were representing different areas local water supply. Daily menus sampled pooled form a composite. Analyses carried out on composite each canteen. UPLC-MS/MS quantification...
Population sodium intake and its impact on public health has been a subject of critical scientific debate for many years. The German Health Interview Examination Survey Adults (DEGS1) facilitate the biomarker-based estimation population, although using spot urine concentrations to extrapolate daily excretion estimates is associated with uncertainties that should be considered. Casual samples 6910 adults collected in DEGS1 were used representatively estimate population. To from excretion,...
For many years, a high sodium intake has been discussed as potential risk factor in the development of hypertension and, consequently, cardiovascular diseases. As part German Health Interview and Examination Survey for Adults (DEGS1), which was conducted between 2008 2011, excretion casual urine samples used biomarker to measure intake. DEGS1 observed that median daily women (3.4 g) well men (4.0 exceeds levels recommended by international organisations. Among other factors, men's higher...
Objective: About one third of the German adult population is affected by hypertension, which often accompanied other metabolic and lifestyle-related changes that may act synergistically to increase risk cardiovascular renal disorders. We thus aimed describe distribution several common factors socio-demographic characteristics according blood pressure (BP) levels in a nationally representative sample 2008-2011. Design method: Cross-sectional analyses were performed 6788 participants aged...
Background: The estimation of exposure to a certain substance has take into account all pathways. Particularly young children ingest dust particles because their so called mouthing behavior whereby is ingested by licking loaded products or hand-to-mouth contacts. Therefore, substances that can be found in house (non-volatile low-volatile compounds) are important at this particular age. Exposure estimates via intake usually performed with the help default assumptions based on tracer studies...
Background and Aim: Perfluorinated alkylated substances are in focus of recent research activities because their potential toxic properties widespread occurrence the environment. Within frame PERFOOD project (KBBE-227525), an evaluation exposure to perfluorinated from house dust has been performed by analysis currently available literature order evaluate importance as a carrier compared food pathway. Method: The focused on 16 different substances. Deterministic estimations based average...
We evaluated the total exposure of toddlers to Di(2-ethylhexyl) phthalate (DEHP) and Di-isononyl (DINP). In addition food, house dust represents an important path particularly in this age. Original data from German Environmental Survey for Children (GerES IV) have been used estimate DINP DEHP via dust. Deterministic probabilistic estimations intake are based on 600 representatively collected samples GerES IV (Gefahrstoffe - Reinhaltung der Luft 70, 2010). For estimations, concentrations were...