A5046057999- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Respiratory viral infections research
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Viral Infections and Vectors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- Animal Disease Management and Epidemiology
- Bacteriophages and microbial interactions
- Hepatitis Viruses Studies and Epidemiology
- Human Health and Disease
- Systemic Sclerosis and Related Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and Retrovirus Studies
- Immune Response and Inflammation
- Synthesis and Reactions of Organic Compounds
- Yersinia bacterium, plague, ectoparasites research
- Herpesvirus Infections and Treatments
- Vector-Borne Animal Diseases
- Immune Cell Function and Interaction
Gamalei Institute of Epidemiology and Microbiology
2002-2024
National Research Centre
2018-2024
Ministry of Health of the Russian Federation
2011-2024
National Centre for Research and Development
2024
Institute of Virology of the Slovak Academy of Sciences
2016
Academy of Medical Sciences
1966-2010
Russian Academy of Sciences
1994-2010
Odesa I. I. Mechnikov National University
2009
L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases of the National Academy of Medical Sciences of Ukraine
2009
Czech Academy of Sciences, Institute of Experimental Medicine
2008
Introduction. Interferons are produced in response to the presence of pathogens cells and responsible for proper formation immune reaction. Preliminary data obtained studies properties recombinant interferon gamma (IFN-γ) that involved patients with community-acquired pneumonia (including bacterial), acute respiratory viral infection (ARVI), influenza new coronavirus have shown promising results.The purpose study was assess effect subcutaneous administration IFN-γ on changes vital signs...
The review contains a brief analysis of the 60-year history discovery, study and medical application interferons, new group remarkable proteins that have found wide in therapy virological, oncological, neurological, ophthalmic other pathologies. Modern data on classification interferons mechanisms their action are given. Particular attention is paid to clinical use medications interferon its inducers.Обзор содержит краткий анализ 60-летней истории открытия, изучения и медицинского применения...
The coronavirus disease (COVID-19) pandemic has brought into sharp relief the threat posed by coronaviruses and laid foundation for a fundamental analysis of this viral family, as well search effective anti-COVID drugs. Work is underway to update existent vaccines against COVID-19, screening low-molecular-weight drug candidates outpatient medicine continues. opportunities ways accelerate development antiviral drugs other pathogens are being discussed in context preparing next pandemic. In...
We have studied dose effects of several Interferon (IFN) inducers, i.e., Genfaxon (beta-1 IFN), Cycloferon and Immunomax upon expression six genes controlling the signaling in immune pathways (TLR3, TLR4, RIG1, IRF3, IPS, B2M), by means real-time RT-PCR, being tested with blood cells from three humans. It is revealed that individual cell samples showed different sensitivity to these drugs, probably, due constitutive levels TLR3 TLR4 gene possible connections their pathology. at a 10 4 ME...
Objective. To study of known interferons (IFN) type I and IFN-inductors drugs different chemical structure on cell differentiation expression group genes TLR/RLRs, referring to pattern-recognition receptors. Materials methods. Cellular lines ТНР-1 (acute monocytic leukemia) и НСТ-116 (colon adenocarcinoma) were treated by Reaferon, Altevir, Genfakson, Infibeta 10 5 -10 6 МЕ, Ridostin 2 3 ßg/ml, Cycloferon 625 ßg/ml Imunomax МЕ during 24 h or 96 at 37 °С. Gene estimated method qRT-PCR...
Jodantipyrin or 4-iodo-1,5-dimethyl-2-phenyl-pyrazol-3-one is an iodinated form of antipyrine which belongs to the group non-steroidal anti-inflammatory drugs. The parent compound, antipyrine, keto derivative pyrazoline and oldest known synthetic drug. primery pharmacological activity based on its properties induce endogenous type 1 interferons. action produces several effects such as reduction degranulation mast cells; suppression prostaglandins arachidonic acid synthesis; cell membrane...
There is represented the current classification of interferon inducers various chemical groups related to antiviral agents, described mechanisms synthesis different types endogenous in blood serum. The effectiveness methylglucamine acridonacetates integrated treatment chronic hepatitis C, tuberculosis with HIV infection background, brucellosis, arboviral diseases, including West Nile fever , as well influenza and acute respiratory infections are shown. For successful diseases should be...
Наровлянский А.Н
The levels of TLR/RLR gene expression and production some cytokines were studied in monocytic THP-1 cell line during its differentiation to mature macrophage-like forms induced by phorbol 12-myristate 13-acetate (PMA) treatment for 1 5 days vitro. For the first time, we have shown high induction genes that encode signaling immune receptors transcription factors response PMA, as well inhibitory effects TLR3, TLR7/TLR8, TLR9-agonists macrophages. PMAactivated cells secreted large quantitities...
The innate immune receptors TLR4, TLR7, TLR8, and RIG1 recognized the structures of influenza viruses in human lymphocytes were activated by recombinant avian virus A/Vietnam/1203/04 its escape-mutant m13(13) during early period interaction. stimulated levels are not connected with viral reproduction. Donor cells low constitutive gene expression showed higher stimulation. Inflammation effects resulted increasing production TNF-alpha IFN-gamma lymphocytes. Signaling reactions parent mutant...
Interferons (IFN) belong to key cytokine? of innate and adaptive immune response play an important role in anti-viral anti-tumor protection. At the same time, they possess a pronounced immune-modulating, anti-proliferative anti-fibrotic effect. A general comparative characteristic human IFN type I (a/(3), II (y) III (X) nosological directionality contemporary drugs created on their base is examined review. Epidemiologic parameters for main socially-significant diseases viral etiology are...