A5049228102- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Genomics, phytochemicals, and oxidative stress
- interferon and immune responses
- Cellular Mechanics and Interactions
- Animal Virus Infections Studies
- Hippo pathway signaling and YAP/TAZ
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- Glutathione Transferases and Polymorphisms
- Caveolin-1 and cellular processes
- Tannin, Tannase and Anticancer Activities
- Management, Economics, and Public Policy
- Diverse academic and cultural studies
University of Padua
2018-2022
mTOR activation is a hallmark of T-cell acute lymphoblastic leukemia (T-ALL) and associated with resistance to glucocorticoid (GC)-based chemotherapy. We previously showed that altering redox homeostasis primes T-ALL cells GC-induced apoptosis. Here we investigated the connection between pathway using pharmacological inhibitors gene silencing. In vitro studies performed on cell lines CG-resistant patient-derived xenograft (PDX) inhibitor everolimus increased reactive oxygen species (ROS)...
Abstract Approximately 20% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients are currently incurable due to primary or secondary resistance glucocorticoid-based therapies. Here we employed an integrated approach selectively kill T-ALL cells by increasing mitochondrial reactive oxygen species (ROS) using NS1619, a benzimidazolone that activates the K + (BK) channel, and dehydroepiandrosterone (DHEA), which blunts ROS scavenging through inhibition pentose phosphate pathway....
Abstract Mechanical forces control cell behavior, including cancer progression. Cells sense through actomyosin to activate YAP. However, the regulators of F-actin dynamics playing relevant roles during mechanostransduction in vitro and vivo remain poorly characterized. Here we identify Fascin1 bundling protein as a factor that sustains YAP activation response ECM mechanical cues. This is conserved mouse liver, where regulates YAP-dependent phenotypes, human cholangiocarcinoma lines....