A5045174918- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Plant Surface Properties and Treatments
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Caveolin-1 and cellular processes
- Wnt/β-catenin signaling in development and cancer
- Lipid metabolism and biosynthesis
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Plant responses to water stress
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Cellular transport and secretion
- Virus-based gene therapy research
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
Vita-Salute San Raffaele University
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2024
University of Padua
2015-2021
Abstract Background The αvβ6- and αvβ8-integrins, two cell-adhesion receptors upregulated in many solid tumors, can promote the activation of transforming growth factor-β (TGFβ), a potent immunosuppressive cytokine, by interacting with RGD sequence latency-associated peptide (LAP)/TGFβ complex. We have previously described chromogranin A-derived peptide, called “peptide 5a ”, which recognizes RGD-binding site both αvβ6 αvβ8 high affinity selectivity, efficiently accumulates or αvβ8-positive...
Rationale: The αvβ6- and αvβ8-integrins, two cell-adhesion receptors upregulated in many tumors involved the activation of latency associated peptide (LAP)/TGFβ complex, represent potential targets for tumor imaging therapy. We investigated tumor-homing properties a chromogranin A-derived containing an RGDL motif followed by chemically stapled alpha-helix (called "5a"), which selectively recognizes LAP/TGFβ complex-binding site αvβ6 αvβ8. Methods: Peptide 5a was labeled with IRDye 800CW (a...
Abstract Mechanical forces control cell behavior, including cancer progression. Cells sense through actomyosin to activate YAP. However, the regulators of F-actin dynamics playing relevant roles during mechanostransduction in vitro and vivo remain poorly characterized. Here we identify Fascin1 bundling protein as a factor that sustains YAP activation response ECM mechanical cues. This is conserved mouse liver, where regulates YAP-dependent phenotypes, human cholangiocarcinoma lines....
Abstract From September 20 to 23, 2023, the Seventh International Cancer Immunotherapy Conference was hosted jointly by Research Institute, European Network for (ENCI), and American Association (AACR) in Milan, Italy. The four-day event covered latest advances cancer immunology immunotherapy.
Abstract Mechanical forces control cell behavior, including cancer progression. Cells sense through actomyosin and YAP, but what regulators of actin mechanotransduction play relevant roles in vivo remains unclear. Here we identify the Fascin1 F-actin bundling protein as a key factor sustaining YAP activation response to ECM mechanical cues. This is mouse liver, where regulates YAP-dependent hepatocyte dedifferentiation. Moreover, required AKT/NICD system sufficient together with AKT induce...