A5013496328- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- RNA and protein synthesis mechanisms
- Glioma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- ATP Synthase and ATPases Research
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Acute Lymphoblastic Leukemia research
Molecular Oncology (United States)
2024
Istituto Oncologico Veneto
2012-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Cornell University
2022-2024
Weill Cornell Medicine
2022
University of Padua
2012-2020
University of Milan
2007
Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic activated in cancer cells drive sustained increase ROS production, and are strongly addicted to the increased activity of scavenging maintain below levels produce macromolecular damage engage death pathways. Consistent with this notion, tumor more vulnerable than their normal counterparts pharmacological treatments production inhibit...
Anti-VEGF therapy perturbs tumor metabolism, severely impairing oxygen, glucose, and ATP levels. In this study, we investigated the effects of anti-VEGF in multiple experimental models that differ their glycolytic phenotypes to gain insights into optimal modulation metabolic features therapy. Prolonged treatments induced vascular regression necrosis xenograft models, with highly tumors becoming treatment resistant more rapidly than poorly tumors. By PET imaging, prolonged yielded an increase...
Abstract Background The Italian Liver Cancer (ITA.LI.CA) prognostic system for patients with hepatocellular carcinoma (HCC) has recently been proposed and validated. We sought to explore the relationship among ITA.LI.CA variables (ie tumour stage, functional score based on performance status Child‐Pugh score, alpha‐fetoprotein), treatment selection survival outcome in HCC patients. Patients Methods analysed 4,867 consecutive undergoing six main strategies (liver transplantation, LT; liver...
Abstract Purpose: LKB1 is a key sensor of metabolic stress, including hypoxia and glucose deprivation, two features the tumor microenvironment exacerbated by antiangiogenic therapy. We investigated role as potential predictive marker sensitivity to bevacizumab in advanced non–small cell lung cancer (aNSCLC). Experimental design: retrospectively analyzed expression IHC 98 samples from 125 patients with aNSCLC, 59 treated chemotherapy 39 plus bevacizumab. intensity was recoded classes...
mTOR activation is a hallmark of T-cell acute lymphoblastic leukemia (T-ALL) and associated with resistance to glucocorticoid (GC)-based chemotherapy. We previously showed that altering redox homeostasis primes T-ALL cells GC-induced apoptosis. Here we investigated the connection between pathway using pharmacological inhibitors gene silencing. In vitro studies performed on cell lines CG-resistant patient-derived xenograft (PDX) inhibitor everolimus increased reactive oxygen species (ROS)...
The onset of chemo-resistant recurrence represents the principal cause high-grade serous ovarian carcinoma (HGSOC) death. HGSOC masses are characterized by a hypoxic microenvironment, which contributes to development this phenotype. Hypoxia regulated-miRNAs (HRMs) represent molecular response cancer cells hypoxia and involved in tumor progression. We investigated expression HRMs using miRNA data from total 273 advanced-stage samples. miRNAs associated with chemoresistance survival were...
The liver kinase B1 (LKB1) gene is a tumor suppressor with an established role in the control of cell metabolism and oxidative stress. However, whether dis-regulated stress promotes growth LKB1-deficient tumors remains substantially unknown. Through vitro studies, we observed that loss LKB1 perturbed expression several genes involved ROS homeostasis. In particular, this analysis evidenced strongly up-modulated NADPH oxidase 1 (NOX1) transcript levels cells lacking LKB1. NOX1 accounted part...
Despite the introduction of directly acting antivirals (DAAs), for treatment hepatitis C virus (HCV) infection, their cost, patient compliance, and viral resistance are still important issues to be considered. Here, we describe generation a novel JFH1-based HCV subgenomic replicon double reporter cell line suitable testing different antiviral drugs therapeutic interventions. This cells allowed rapid accurate quantification growth/viability RNA replication, thus discriminating specific from...
Graphical abstractAbstractInterferon-α (IFN-α) comprises a family of 13 cytokines involved in the modulation antiviral, immune, and anticancer responses by orchestrating complex transcriptional network. The activation IFN-α signaling pathway endothelial cells results decreased proliferation migration, ultimately leading to suppression angiogenesis. In this study, we knocked-down expression seven established or candidate modulators response reconstruct gene regulatory network investigate...
Inference of gene regulation from expression data may help to unravel regulatory mechanisms involved in complex diseases or the action specific drugs. A challenging task for many researchers working field systems biology is build up an experiment with a limited budget and produce dataset suitable reconstruct putative modules worth biological validation. Here, we focus on small-scale screens introduce novel experimental set-up customized method analysis make inference starting genetic...
Abstract Prednisone is an anti-inflammatory glucocorticoid (GC) that cytotoxic for normal and malignant B cells and, on this basis, has long been included in combination chemotherapies to treat aggressive B-cell lymphomas. However, the mechanisms by which GCs kill lymphoma still largely remains elusive due pleiotropic consequences of GC binding receptor (GR; NR3C1), a ligand-induced transcription factor. This prompted us search critical direct targets action with hypothesis may inhibit key...
Abstract Approximatively 40% of diffuse large B-cell lymphoma (DLBCL) patients exhibit primary resistance to standard therapy. Moreover, relapse is a common event in first-line responders. Overexpression BCL-2 major determinant chemotherapy several neoplasms, including DLBCL. While venetoclax, specific inhibitor, has dramatically changed the therapeutic landscape other malignancies, only 12% DLBCL complete response with mean progression-free survival 1 month. In this scenario, new strategies...