Two nanoscale covalent organic frameworks as drug carriers with good biocompatibility were developed, showing high loading capacity and sustained release <italic>in vitro</italic>.

We report for the first time use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In present system, performed four important roles: (i) "nanocarriers" delivery; (ii) "phototriggers" release; (iii) chromophores cell imaging; and (iv) detectors real time-monitoring release. vitro biological studies revealed that newly developed exhibit good biocompatibility cellular uptake well efficient photoregulated anticancer release ability. Such may open up new...

Ultrafine palladium nanoparticles (Pd NPs) with 8 and 3 nm sizes were effectively fabricated in triazine functionalized porous organic polymer (POP) TRIA that was developed by nonaqueous polymerization of 2,4,6-triallyoxy-1,3,5-triazine. The Pd NPs encapsulated POP (Pd-POP) fully characterized using several techniques. Further studies revealed an excellent capability Pd-POP for catalytic transfer hydrogenation alkenes at room temperature superior performance high selectivity desired...

An organic nanoparticle-based drug delivery system with high loading efficacy (∼79 wt %) was developed using a perylene-derived photoremovable protecting group, namely, perylene-3,4,9,10-tetrayltetramethanol (Pe(OH)4). The anticancer chlorambucil protected by coupling Pe(OH)4 to form photocaged nanoparticles (Pe(Cbl)4). photorelease mechanism of from the Pe(Cbl)4 conjugate investigated experimentally high-resolution mass spectrometry and theoretically density functional theory calculations....

'Aggregation Induced Emission + Excited State Intramolecular Proton Transfer (AIE ESIPT)'-assisted photorelease of an anticancer drug by a p-hydroxyphenacyl (pHP) phototrigger with real-time monitoring has been demonstrated.

Recently, photoresponsive nanoparticles have been widely used to develop drug delivery systems (DDSs) wherein light is as an external stimulus trigger release in a spatially and temporally controlled fashion. Real time monitoring DDSs are also gaining much interest due their capability of situ. In this context we designed new real nanoparticle based on photoluminescent silicon quantum dots (SiQDs) using the o-nitrobenzyl (ONB) derivative phototrigger for anticancer chlorambucil (Cbl). The...

The lithium–sulfur (Li–S) battery presents a promising rechargeable energy storage technology for the increasing demand in worldwide range. However, current main challenges Li–S are structural degradation and instability of solid-electrolyte interphase caused by dissolution polysulfides during cycling, resulting corrosion loss active materials. Herein, we developed novel hybrids employing metal–organic polyhedron (MOP) encapsulated PVP-functionalized sulfur nanoparticles (S@MOP), where...

In recent times, organelle-targeted drug delivery systems have gained tremendous attention due to the site-specific of active molecules, resulting in enhanced bioefficacy. this context, a phototriggered system (DDS) for releasing an molecule is superior, as it provides spatial and temporal control over release. So far, near-infrared (NIR) light-responsive DDS has not yet been developed. Hence, we introduced two-photon NIR lysosome-targeted "AIE + ESIPT" single-component based on naphthalene...

A NIR light-responsive phenothiazine based phototherapeutic system for synergistic cancer treatment.

Fe₃O₄@GO behaves as magnetic heterogeneous nanocatalyst for alkene hydrogenation using hydrazine hydrate hydrogen source with high TOF values.

A versatile heterogeneous photocatalysis protocol was developed by using ruthenium bipyridyl tethered porous organosilica (Ru-POS). The versatility of the Ru-POS catalyst in organo-photocatalysis explored (i) oxidative aromatization Hantzsch ester, (ii) reductive dehalogenation alkyl halides, and (iii) functional group interconversion (FGI) alcohols to halides.

A new fluorescent photoremovable protecting group (FPRPG) based on acetylcarbazole framework has been explored for the first time release of single and dual (similar or different) substrates from chromophore. Mechanistic studies photorelease process revealed that two acetyl carbazole proceeds via a stepwise pathway. Further, we constructed photoresponsive drug delivery system (DDS) to different anticancer drugs (caffeic acid chlorambucil, 1 equiv each). In vitro study reveals our DDS exhibit...

A novel controlled-release formulation (CRF) of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was developed to reduce its negative environmental impacts by improving herbicidal efficacy. The 2,4-D chemically caged coupling with photoremovable protecting groups (PRPGs) coumarin derivatives. Photophysical studies compounds showed that they all exhibited strong fluorescence properties. Controlled release achieved irradiating using UV−vis light (310, 350, and 410 nm). effect various...

We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) regulated anticancer release. Acridin-9-methanol fluorescent nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ delivery, (ii) ″phototrigger″ release, and (iii) chromophore cell imaging. In vitro biological studies reveal acridin-9-methanol of ~60 nm size to be very efficient delivering chlorambucil into target nucleus, killing...

Herein, we report three new metal-free, photochemically active single, dual, and combinatorial CORMs (photoCORMs) based on a carbazole-fused 1,3-dioxol-2-one moiety which released one equivalent of CO, two combination each CO anticancer drug upon one- two-photon excitation, respectively. The photoCORMs exhibited good cellular uptake real-time monitoring ability uncaging by color change approach in cancerous B16F10 cells. Interestingly, the cytotoxicity assay cells indicated that dual...

Highly sensitive hypoxia (H2O2)-activated photoresponsive polymeric nanoparticles for cocktail delivery of anticancer drugs doxorubicin (Dox) and chlorambucil (Cbl) were developed. The polymer conjugate was constructed by ring-opening polymerization (ROP) caprolactone (as the tail) with 7-hydroxycoumarin head). During nanoprecipitation, polycaprolactone chain wrapped around hydrophobic core (coumarin chlorambucil) to form a "shell". Interestingly, polycaprolactone-tagged...

Organic near-infrared (NIR) fluorescent probes have been recognized as an emerging class of materials exhibiting a great potential in advanced bioanalytical applications. However, synthesizing such organic that could simultaneously work the NIR spectral range and large Stokes shift, high stability biological systems, photostability proven challenging. In this work, aggregation induced excimeric emission aqueous media was observed from suitably substituted perylene monoimide (PeIm) dye....

A highly active hybrid material (RGS@AuNPs), as an efficient catalyst, is successfully synthesized for the reduction of 4-nitrophenol and methylene blue in presence NaBH₄, well photocatalytic decomposition blue.

We report a new multi-tasking water-soluble photocage based on well-known rhodamine dye for cancer cell selective anticancer drug delivery triggered by green light.

A FRET donor-acceptor xanthene-coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The "locked" pair was selectively "unlocked" by biological reducing thiols via rupture a sacrificial disulfide linker. distinct change in fluorescence color selective cancer cell toxicity were observed vitro.

Vapochromic behavior is employed to selectively monitor the vapor changes in surrounding environment, particularly for toxic gas leaking and floating detection. Thus, sensitive trapping accurate response different vapors are critical factors vapochromic sensing. In this work, a self-assembled hybrid that consists of fluorescent organic octahedron encapsulated by metal–organic polyhedron (MOP) reported. The used as responsive sensor probe various solvent vapors, while MOP protector prevent...