A5003159388- Catalytic Cross-Coupling Reactions
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Pyrroles
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Cyclopropane Reaction Mechanisms
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Crystallography and molecular interactions
- Synthesis and Reactivity of Heterocycles
- Biochemical effects in animals
- Catalytic Alkyne Reactions
- Bacteriophages and microbial interactions
- Multicomponent Synthesis of Heterocycles
- Synthetic Organic Chemistry Methods
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- SARS-CoV-2 and COVID-19 Research
- Plant Virus Research Studies
- Cancer therapeutics and mechanisms
- Biochemical and Structural Characterization
- Nanoparticles: synthesis and applications
- Amino Acid Enzymes and Metabolism
- Marine Sponges and Natural Products
Indian Institute of Technology Kharagpur
2020-2025
Haldia Institute of Technology
2013-2017
Vidyasagar University
2017
Antimicrobial resistance poses a serious threat to global health, necessitating the exploration of innovative solutions.
To understand SARS-CoV-2 microevolution, this study explored the genome-wide frequency, gene-wise distribution, and molecular nature of all point-mutations detected across its 71,703 RNA-genomes deposited in GISAID till 21 August 2020. Globally, nsp1/nsp2 orf7a/orf3a were most mutation-ridden non-structural structural genes respectively. Phylogeny 4618 spatiotemporally-representative genomes revealed that entities belonging to early lineages are mostly spread over Asian countries, including...
N -Glycidyl d -tryptophan ether derivative may be suitable for use as ointment base to reduce the inflammation, ROS, DNA damage and bacterial load over wounds.
An efficient one pot synthesis of polycyclic benzimidazole derivatives has been developed (up to 90% yield).
We have reported a one-pot two step methodology for the synthesis of highly condensed pyrrolo[1,2-<italic>a</italic>][1,4]benzodiazepines by modified Pictet–Spengler reaction.
Herein, we report an efficient synthesis of N-substituted pyrrole derivatives and their application to construct macrocyclic oxazocinone via a two-component coupling reaction followed by base mediated intramolecular cyclization. This methodology provides easy two-step approach constitute library fused pyrrolo-oxazocinone in good yields under mild conditions. The present offers access the fluorescent pyrole derivatives. Among them, tert-butyl...
A novel class of bridgehead nitrogen heterocycles, pyrido[1,2-<italic>a</italic>]pyrimidinium ions, has been readily synthesized by a two-step one-pot reaction in high yields (up to 93%).
Herein, we report a rare pentacyclic N-fused hetrocycle synthesis via palladium catalyzed intramolecular C−H arylation along with the brief synthetic study of new type bicyclic/tricyclic pyrrole rings. This rings provided diversely substituted polycyclic nitrogen fused heterocycles from N-benzyl/N-benzyloxy pyrroles good to excellent yields.
A short, efficient and general methodology for benzo[ b ]carbazolenaphthoquinones was developed via Pd‐catalyzed C‐H arylation process. This successfully applied to the synthesis of highly biologically active compound 5H–benzo[ ]carbazole‐6,11‐diones. Additionally, one‐pot ]phenazine‐6,11(5H,12H)‐dione derivatives also explored in aqueous medium.
A simple and facile approach for the synthesis of various structurally different tricyclic bent oxepine frameworks from a readily accessible precursor has been introduced. The substituted derivative involved Pd(0)-catalyzed Heck reaction. This methodology enriches literature large ring formation.
A novel synthesis of 3,4-fused furans (both tricyclic and bicyclic) through platinum-catalyzed cyclization 3-(2-formylcycloalkenyl)-acrylic amides 2 in methanol is described (up to 90% yield). Tricyclic dihydrofuran derivatives were also obtained via reductive 2. The substrates from β- bromovinyl aldehydes by a Pd-catalyzed Heck reaction.
Abstract Various 3,4‐fused polycyclic furan derivatives, e.
Abstract A variety of pyrrole and isoquinoline derivatives (II), (IV), (VI) are synthesized via aza‐exo‐trig aza‐endo‐dig cyclization alkenyl or alkynyl carbaldehydes (I), (III), (V), respectively.
Abstract Fluorescence properties of the formed benzimidazoles in different solvents and at pH are investigated.