A5101920277- Reading and Literacy Development
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Vestibular and auditory disorders
- Cognitive and developmental aspects of mathematical skills
- Brain Tumor Detection and Classification
- Tactile and Sensory Interactions
- Medical Image Segmentation Techniques
- Advanced Neural Network Applications
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Hemispheric Asymmetry in Neuroscience
- Temporomandibular Joint Disorders
- Educational Methods and Media Use
- Child Development and Digital Technology
- Hearing, Cochlea, Tinnitus, Genetics
- Multisensory perception and integration
- Language Development and Disorders
- Neonatal and fetal brain pathology
- Phonetics and Phonology Research
- Memory and Neural Mechanisms
- Angiogenesis and VEGF in Cancer
Beijing University of Posts and Telecommunications
2023-2025
Peking University
2016-2024
Maastricht University
2019-2024
University of Hong Kong
2023
Imaging Center
2022
University of Manitoba
2018
Structural magnetic resonance imaging (sMRI) is an essential part of the clinical assessment patients at risk Alzheimer dementia. One key challenge in sMRI-based computer-aided dementia diagnosis to localize local pathological regions for discriminative feature learning. Existing solutions predominantly depend on generating saliency maps pathology localization and handle task independently task, leading a complex multi-stage training pipeline that hard optimize with weakly-supervised...
Statistical learning, or the ability to extract statistical regularities from sensory environment, plays a critical role in language acquisition and reading development. Here we employed electroencephalography (EEG) with frequency-tagging measures track temporal evolution of speech-structure learning individuals difficulties due developmental dyslexia typical readers. We measured EEG while participants listened (a) structured stream repeated tri-syllabic pseudowords, (b) random same...
The engagement of the cerebellum VI in reading was reported both typically developing and dyslexic readers. However, it is still not clear how contributes to reading. Here we have examined correlation intrinsic cerebro-cerebellar functional connectivity with two critical reading-related skills-phonological awareness (PA) rapid automatized naming (RAN)-with fMRI technology. Specifically, tested hypothesis that may contribute either by phonological skills or automatizing skills. We chose left...
Natural Killer (NK) cells and dendritic (DC) are two innate immune that critical in regulating adaptive immunity. Cellular functions migratory responses of NK or DC can be further regulated NK-DC crosstalk involves multiple cytokine signals and/or direct cell-cell contacts. Semaphorin-3E (Sema-3E) is a member large family Semaphorin proteins play diverse regulatory different biological systems upon its binding to the cognate receptors. However, possible role(s) Sema-3E on regulation NK-cell...
It is widely accepted that impairment in visual perception impedes children's reading development, and further studies have demonstrated significant enhancement fluency after perceptual training. However, the mechanism of neural linkage between unclear. The purpose this study was to examine intrinsic functional relationship (indexed by texture discrimination task,TDT) ability (character fluency) Chinese children with developmental dyslexia (DD) those typical development (TD). resting-state...
Abstract Prior work has extensively studied neural deficits in children with reading impairment ( RI ) their native language but rarely examined those of second (L2). A recent study revealed that the function local brain regions was disrupted L2, it is not clear whether disruption also occurs at a large‐scale network level. Using fMRI and graph theoretical analysis, we explored topology whole‐brain functional during phonological rhyming task reconfigurations across short resting phases...
Medical imaging is now a widely used test for the preoperative evaluation of focal cortical dysplasia (FCD). Deep learning-based methods can learn lesion features from image data to automatically recognize and segment FCD in epilepsy treatment. However, existing segmentation networks lack ability fully extract information aggregate salient lesions, accuracy needs be improved. To this end, we propose an end-to-end 3D Convolutional Neural Network model, Multi Attention Two-Path Residual UNet...
The mental parsing of linguistic hierarchy is crucial for language comprehension, and while there growing interest in the cortical tracking auditory speech, neurophysiological substrates written are still unclear. We recorded electroencephalographic (EEG) responses from participants exposed to visual streams either random syllables or tri-syllabic real words. Using a frequency-tagging approach, we analyzed neural representations physically presented (i.e., syllables) mentally constructed...
Additional neural substance for reading in a second language has been reported by prior studies. However, to date, there little investigation into whether and how the brain's adaptation is induced specific linguistic tasks or general effect during new language. To address this issue, our study investigated Chinese children learning English as combining cross-sectional longitudinal Functional Magnetic Resonance Imaging (fMRI) We compared brain activation across four tasks, orthographic...
Focal cortical dysplasia (FCD) is the most common pathological cause for pediatric epilepsy, with frontal lobe epilepsy (FLE) being prevalent in population. We attempted to utilize radiomic and morphological methods on MRI PET detect FCD children FLE.Thirty-seven FLE 20 controls were included primary cohort, a five-fold cross-validation was performed. In addition, we validated performance an independent site of 12 children. A two-stage experiments including subregions employed lesion area...
Learning to read a second language (L2) can pose great challenge for children who have already been struggling in their first (L1). Moreover, it is not clear whether, what extent, and under circumstances L1 reading difficulty increases the risk of L2 difficulty. This study investigated Chinese (L1) English skills large representative sample 1,824 Chinese-English bilingual Grades 4 5 from both urban rural schools Beijing. We examined prevalence only (poor readers, PC), PE), PB) calculated...
Purpose: To investigate the radiographic characteristics of temporomandibular joint (TMJ) disorders using cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI), to examine therapeutic effectiveness intra-articular betamethasone injection in management TMJ pathologies. Methods: A total forty (40) patients diagnosed with suspected (study group) 40 healthy volunteers (control who underwent comprehensive examinations Department Stomatology Rehabilitation Medicine, Qiqihar...
Abstract Whether reading in different writing systems recruits language-unique or language-universal neural processes is a long-standing debate. Many studies have shown the left arcuate fasciculus (AF) to be involved phonological and processes. In contrast, little known about role of right AF reading, but some suggested that it may play visual spatial aspects prosodic components language. The more important for Chinese due its logographic tonal properties, this hypothesis has yet tested. We...
Applying 10 Hz (α-rate) sensory stimulation, not 5 (θ-rate), prior to introducing novel speech-print pairs can reset the phase of θ oscillations and enhance associative learning. This rapid gain indicates coordinated mechanisms regulate attentional/cognitive resources (α oscillations) facilitate memory storage (θ early in The present findings may inform educational practices for children with reading difficulties.
The engagement of the cerebellum in reading is not unprecedented. However, it still unclear which regions are specifically involved and how processes different languages. With functional magnetic resonance imaging, we compared cerebellar neural activity Chinese child learners English between non-reading tasks to identify functionally specialized areas for reading, characters words a passive viewing paradigm detect sensitive scripts. We first focused on right lobule VI, during observed two...