A5073233594- Organoboron and organosilicon chemistry
- Asymmetric Hydrogenation and Catalysis
- Systemic Lupus Erythematosus Research
- Chemical Synthesis and Analysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Synthesis and Reactions
- Extracellular vesicles in disease
- Cytokine Signaling Pathways and Interactions
- Advanced Synthetic Organic Chemistry
- Asymmetric Synthesis and Catalysis
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- interferon and immune responses
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Protein Degradation and Inhibitors
- Atherosclerosis and Cardiovascular Diseases
- Catalytic C–H Functionalization Methods
- Pregnancy and Medication Impact
- Apelin-related biomedical research
- Boron Compounds in Chemistry
Vall d'Hebron Institut de Recerca
2015-2025
Universitat Autònoma de Barcelona
2015-2025
Universitat Rovira i Virgili
2011-2014
Durham University
2013
The potential role of new oral anticoagulants in antiphospholipid antibody syndrome (APS) remains uncertain.To determine whether rivaroxaban is noninferior to dose-adjusted vitamin K antagonists (VKAs) for thrombotic APS.3-year, open-label, randomized noninferiority trial. (EU Clinical Trials Register: EUDRA [European Union Drug Regulatory Authorities] code 2010-019764-36).6 university hospitals Spain.190 adults (aged 18 75 years) with APS.Rivaroxaban (20 mg/d or 15 mg/d, according renal...
Despite overall improvement in prognosis, 10–30% of patients with lupus nephritis (LN) will develop end-stage renal disease. To date, biopsy is still the 'gold standard' test used to predict outcome. However, due its invasive nature, new non-invasive biomarkers are required. Urinary exosomes, microvesicles released by every epithelial cell facing urinary space, represent an ideal source markers for dysfunction and injury. Here, we sought evaluate miR-29c expression levels exosomes as a novel...
For lupus nephritis (LN) management, it is very important to detect fibrosis at an early stage. Urinary exosomal miRNAs profiling can be used as a potential multi-marker phenotyping tool identify fibrosis. We isolated and characterised urinary exosomes cellular pellets from patients with biopsy-proven LN (n = 45) healthy controls 20). chronicity index (CI) correlated miR-21, miR-150, miR-29c (r 0.565, 0.840, −0.559, respectively). This miRNA profile distinguished low CI moderate-high in high...
Organocatalytic nucleophilic pinacolboryl addition from in situ generated MeO− → B2pin2 to CN double bond can be performed enantioselectively with the aid of chiral phosphines, which promote enantiofacial differentiation course C–B formation.
The use of chiral alcohols to form the Lewis acid-base *RO(-)→ bis(pinacolato)diboron adduct, in situ, provides an opportunity induce asymmetry organocatalytic diboration alkenes and complements well established transition metal-mediated enantioselective diboration.
Data on exosomal-derived urinary miRNAs have identified several associated with disease activity and fibrosis formation, but studies prognosis are lacking. We conducted a qPCR array screening exosomes from 14 patients biopsy-proven proliferative lupus glomerulonephritis renal outcome of clinical response (n = 7) non-response following therapy. Validation were performed by qRT-PCR in new nephritis (LN) cohort (responders 22 non-responders 21). Responder expressed significantly increased...
Piece of the (inter)action: The interaction alkoxides with sp(2) Bpin (pin=pinacol) moiety in aminoboranes forms situ Lewis acid-base adduct [RO(-) →B(OR)2 N(R')2 ] which enables amino to react as a strong nucleophile several electrophiles, thus providing alcohols, β-enamino esters, and β-hydroxy amides direct remarkably selective way.
Despite conventional therapy, lupus nephritis (LN) remains a significant contributor to short- and long-term morbidity mortality. B cell abnormalities the production of autoantibodies against nuclear complexes like anti-dsDNA are recognised as key players in pathogenesis LN. To address challenges chronic immunosuppression associated with current therapies, we have engineered T cells express chimeric autoantibody receptors (DNA-CAART) for precise targeting expressing autoantibodies. from LN...
Abstract A simple one‐pot three‐step synthetic route towards chiral γ‐amino alcohols has been established. Considering the overall stereocontrol of protocol, first and key step is enantioselective β‐boration α,β‐unsaturated imines. By screening a small library potential auxiliaries, several phosphorus ligands have identified which induce exceptional enantioselectivities (up to 99% ee ). For stoichiometric reduction imino group, it found that high levels 1,3‐diastereocontrol can be achieved...
It has been demonstrated that the interaction of a simple Lewis base with tetraalkoxydiboranes generates an unusual nucleophilic character in one boryl moieties. The amines, N -heterocyclic carbenes (NHCs), and alkoxides diboron reagent results formation acid–base adduct, which formally intact sp 2 moiety becomes nucleophilic. We describe this work application new type boron synthon selective preparation organoboranes through β-boration diboration reactions.
Discoid lupus erythematosus (DLE) is characterized by scarring lesions that develop and perpetuate fibrotic lesions. These are not observed in subacute cutaneous (SCLE). The pathophysiological basis of this currently unknown. To identify contradistinctive signalling pathways cellular signatures between the two type lupus, with a focus on molecular mechanisms leading to fibrosis. We conducted gene expression microarray analysis lesional nonlesional skin biopsy specimens patients DLE (n = 10)...
Background Antibodies to M-type phospholipase A2 receptor (a-PLA 2 R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence lupus nephritis (MLN) is still unclear. The objective of this study was assess a-PLA R antibodies a large cohort nephritis. Methods were measured by ELISA serum from systemic erythematosus ( n = 190), whom 37 had biopsy-proven MLN. Positive samples confirmed commercial kit, Western blot and immunohistochemistry renal tissue....
Cutaneous lupus erythematosus (CLE) is a chronic autoimmune skin disorder with limited therapeutic options, particularly for refractory discoid (DLE), which often results in scarring and atrophy. Recent studies have identified miR-31, miR-485-3p, miR-885-5p as key regulators of inflammation, apoptosis, fibrosis CLE lesions. This research investigates novel topical miRNA therapy using DDC642 elastic liposomes to target these pathways CLE. were complexed miRNAs (anti-miR-31, anti-miR-485-3p,...
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder driven by autoreactive B cells and characterized the production of pathogenic autoantibodies. Belimumab, an anti-BAFF monoclonal antibody, has demonstrated efficacy in reducing disease activity corticosteroid use SLE patients, although responses remain variable. B-cell activating factor (BAFF) essential for cell survival autoantibody production, positioning it as key target pathogenesis. MicroRNAs (miRNAs), critical...
Combo effects: The first example of an iron-mediated β-boration activated olefins is reported. origin and the benefits catalytic activity associated with presence iron have been questioned carefully studied. system has compared to organocatalytic α,β-unsaturated esters, ketones, imines (see scheme; acac=acetylacetonate, pin=pinacol).
Abstract A simple one‐pot, three‐step synthetic route to chiral 1,3‐amino alcohols and 1,3‐diols has been established. Considering the overall stereocontrol of protocol, first key step is an enantioselective β‐boration α,β‐unsaturated imines ketones, respectively. The enantioselectivity provided by Cu I catalyst modified with Josiphos‐ Mandyphos‐type ligands examined. oxidative substitution boryl unit a hydroxyl group proceeds complete retention configuration at C β ‐atom. In parallel,...
A one-pot synthesis of chiral amino alcohols from α,β-unsaturated aldehydes is reported which circumvents competitive 1,2- versus 1,4-boryl addition, by means using a sterically hindered amine-derived imine. In addition to the complete chemoselectivity, modification Cu(I) catalyst with readily available diphosphines, such as (R)-DM-BINAP, gave products high levels asymmetric induction.
At present, Lupus Nephritis (LN) is still awaiting a biomarker to better monitor disease activity, guide clinical treatment, and predict patient's long-term outcome. In the last decade, novel biomarkers have been identified disease, but none incorporated into practice. The transmembrane receptor neuropilin-1 (NRP-1) highly expressed by mesangial cells its genetic deletion results in proteinuric glomerulosclerosis. NRP-1 increased kidney biopsies of LN. this work we were interested...
An efficient, 4-step, one-pot, highly stereoselective route to γ-amino alcohols has been developed via an in situ α,β-unsaturated imine formation, β-boration, reduction (CN) and oxidation (C–B) sequence especially for certain water-soluble alcohols, a further step can be added directly access the corresponding 1,3-oxazine derivatives.
Copper(I) has become the preferred metal to catalyze β-boration of α,β-unsaturated carbonyl compounds, and now we demonstrate that easily accessible monodentate chiral ligands, such as phosphoramidites phosphites, can be convenient alternative ligands induce asymmetry in enantioselective version this reaction, particularly imines.
A highly efficient Cu-catalyzed CB bond formation has been developed to transform 1-azadienes into β-imino boronate esters when reacted with bis(pinacolato)diboron and a base. series of functionalized imines oximes were found react under very mild conditions. further oxidation protocol enabled β-iminoalcohols be selectively synthesized. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They...
The selective introduction of a boron unit in an organic framework opens new perspectives both building block design and functionalization protocols. presence carbonyl or imino groups β position with regard to the boryl moiety makes them suitable organoboron intermediates for difunctionalized purposes. Catalytic synthetic methodologies have recently been developed introduce group at β- α,β-unsaturated esters, ketones, aldehydes, amides, nitriles, as well imines oximes. asymmetric version...