A5086552719- Mesenchymal stem cell research
- Autism Spectrum Disorder Research
- Nerve injury and regeneration
- Pluripotent Stem Cells Research
- Cerebral Palsy and Movement Disorders
- Neurogenetic and Muscular Disorders Research
- Muscle Physiology and Disorders
- Genetics and Neurodevelopmental Disorders
- Amyotrophic Lateral Sclerosis Research
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Nerve Injury and Rehabilitation
- Medical and Biological Ozone Research
- Stroke Rehabilitation and Recovery
- Neonatal and fetal brain pathology
- Tissue Engineering and Regenerative Medicine
- Neurological Disease Mechanisms and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Hydrogen's biological and therapeutic effects
- Prosthetics and Rehabilitation Robotics
- COVID-19 and healthcare impacts
- Muscle activation and electromyography studies
- Traumatic Brain Injury Research
- Prion Diseases and Protein Misfolding
Neurogen Brain & Spine Institute
2015-2024
Cellular therapy is an emerging therapeutic modality with a great potential for the treatment of autism. Recent findings show that major underlying pathogenetic mechanisms autism are hypoperfusion and immune alterations in brain. So conceptually, cellular which facilitates counteractive processes improving perfusion by angiogenesis balancing inflammation regulation would exhibit beneficial clinical effects patients This open label proof concept study autologous bone marrow mononuclear cells...
Cerebral palsy is a nonprogressive heterogeneous group of neurological disorders with growing rate prevalence. Recently, cellular therapy emerging as potential novel treatment strategy for cerebral palsy. The various mechanisms by which works include neuroprotection, immunomodulation, neurorestoration, and neurogenesis. We conducted an open label, nonrandomized study on 40 cases aim evaluating the benefit in combination rehabilitation. These were administered autologous bone marrow...
Cell therapy is being widely explored in the management of stroke and has demonstrated great potential. It been shown to assist remodeling central nervous system by inducing neurorestorative effect through process angiogenesis, neurogenesis, reduction glial scar formation. In this study, intrathecal administration autologous bone marrow mononuclear cells (BMMNCs) analyzed on recovery patients with chronic stroke. 24 diagnosed were administered cell therapy, followed multidisciplinary...
Muscular dystrophy is a genetic disorder with no definite cure. A study was carried out on 150 patients diagnosed muscular dystrophy. These included Duchenne dystrophy, limb-girdle and Becker variants. They were administered autologous bone marrow-derived mononuclear cells intrathecally intramuscularly at the motor points of antigravity weak muscles followed by vigorous rehabilitation therapy. No significant adverse events noted. Assessment after transplantation showed neurological...
Traumatic brain injury is an to the parenchyma resulting from external factors such as vehicular accidents, falls, or sports injuries. Its outcome involves primary insult followed by a cascade of secondary insult, in diffuse axonal further causing white matter damage. Surgical intervention targets damage, whereas only few treatment alternatives are available treat Cellular therapy could be one prospective therapeutic options, it has potential arrest degeneration and promote regeneration new...
Abstract Background Chronic Traumatic Brain Injury (TBI) is one of the common causes longterm disability worldwide. Cell transplantation has gained attention as a prospective therapeutic option for neurotraumatic disorders like TBI. The postulated mechanism cell which includes angiogenesis, axonal regeneration, neurogenesis and synaptic remodeling, may tackle pathology chronic TBI improve overall functioning. Methods To study effects transplantation, 50 patients with were enrolled in an open...
Mesenchymal stem cells can serve as a therapeutic option for COVID-19. Their immunomodulatory and anti-inflammatory properties regulate the exaggerated inflammatory response promote recovery of lung damage.Phase-1, single-centre open-label, prospective clinical trial was conducted to evaluate safety efficacy intravenous administration mesenchymal derived from umbilical cord placenta in moderate The study done 2 stages with total 20 patients. Herein, results stage 1 including first 10...
Cerebral palsy (CP) is one of the non-progressive neurological diseases caused by damage to brain tissue at birth, which leads physical, cognitive and perceptive symptoms. Even after lifelong medical therapeutic management there are residual deficits affect quality life patients their families. We examined a maximally rehabilitated, 20 year old male suffering from CP Mental Retardation (MR). He had diplegic gait Intelligence Quotient (IQ) score 44 with affected fine motor activities,...
Abstract Background: Altered size in the corpus callosum (CC) has been reported individuals with autism spectrum disorder (ASD), but few studies have investigated younger children. Moreover, knowledge about age-related changes CC ASD is limited. Objectives: Our objective was to investigate of and compare them age-matched healthy controls between ages 2 18 years. Methods: Structural-weighted images were acquired 97 male patients diagnosed ASD; published data used for control group. The...
Purpose Duchenne muscular dystrophy (DMD) is the most common and severe form of dystrophy. Current diagnostic tests like genetic testing, needle electromyography, muscle biopsy are either not easily available or invasive, they impractical for assessing disease progression treatment outcomes. Therefore, there a need non-invasive accurate investigative modality DMD. In recent years, musculoskeletal magnetic resonance imaging (MRI-MSK) along with fractional anisotropy (FA) diffusion tensor...
Telomeres, located at the ends of each chromosome play a vital role in determining cellular fate and aging. Accelerated shortening telomeres may also result accelerated aging occurrence age-related degenerative diseases. Anti-aging treatments help increasing telomere length along with improving quality life, reducing dependency for daily life activities, expectancy risks associated In this study, we evaluated effect anti-aging integrative therapy 36 individuals. The treatment included...
In response to acute ischemic stroke, large numbers of bone marrow stem cells mobilize spontaneously in peripheral blood that home onto the site ischemia activating penumbra. But with chronicity, mobilized decrease, reducing degree and rate recovery. Cellular therapy has been explored as a new avenue restore repair process chronic stage. A 67-year-old Indian male right middle cerebral artery stroke had residual left hemiparesis despite standard management. Recovery was slow partial resulting...
[18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography scan was performed on 45 children with autism to study the baseline pattern and age-related developmental changes in brain metabolism. Median standardized uptake values (SUVs) were compared published healthy control data. Results showed that, contrary data, median SUVs decrease linearly increase age. As controls, below 5 years greater metabolism older lower In group, comparison of absolute within different...
Becker’s Muscular Dystrophy (BMD) is a dystrophinopathy manifested as progressive muscle degeneration. Autologous Bone Marrow Mononuclear Cells (BMMNCs) have shown some myogenic potential. The paracrine effects of the BMMNCs reduce inflammation and are thought to We treated 39 year old dental surgeon suffering from BMD. Muscle strength was reduced when measured using modified Medical Research Council’s Manual Testing (mMRC-MMT). Static sitting balance poor. He wheelchair dependent for...
Cellular therapy is being actively pursued as a therapeutic modality in many of the neurological diseases. A variety stem cells from diverse sources have been studied detail and shown to exhibit angiogenetic immunomodulatory properties addition other neuroprotective effects. Published clinical data bone marrow mononuclear cell (BMMNC) injection disorders safe possesses regenerative potential. We illustrate case 27-year-old male with traumatic brachial plexus injury, administered autologous...
Abstract: Cerebral palsy (CP), group of permanent nonprogressive clinical disorders in children, is caused by damage to the immature brain. Conventionally available treatments for CP are mainly targeted toward management its symptoms. With upcoming field neurorestorative strategies, we now able repair core brain CP. There various drugs, stem cells, etc, which have been implicated properties. Autologous bone marrow umbilical cord neural and olfactory ensheathing cells shown safety efficacy...
The underlying pathophysiology in intellectual disability (ID) involves abnormalities dendritic branching and connectivity of the neuronal network. This limits ability brain to process information. Conceptually, cellular therapy through its neurorestorative neuroregenerative properties can counteract these pathogenetic mechanisms improve connectivity. improved networking should exhibit as clinical efficacy patients with ID. To assess safety ID, we conducted an open-label proof-of-concept...
Abstract: Limb girdle muscular dystrophy (LGMD), a group of progressive degenerative disorders, causes functional limitation affecting the quality life. Cell therapy is being widely explored and preliminary studies have shown beneficial effects. induces trophic-factors release, angiogenesis, anti-inflammation, protein synthesis, which helps in reparative process at microcellular level. In this 5-year longitudinal study, effect autologous bone marrow mononuclear cells studied on natural...
Spinal cord injury (SCI) at an early age can be debilitating for the child’s growth. Current treatments show a level of stagnancy, after which recovery is minimal. Cellular therapy emerging area research and has been found to possess many benefits in previous studies. Transplantation autologous bone marrow mononuclear cells (BMMNCs) demonstrated therapeutic potential neurological conditions, including spinal injury. Here we report case 6-year-old girl with traumatic SCI C7-D1 4 years back,...