A5020503787- Mesenchymal stem cell research
- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Pluripotent Stem Cells Research
- Nerve injury and regeneration
- Medical and Biological Ozone Research
- Autism Spectrum Disorder Research
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Hydrogen's biological and therapeutic effects
- COVID-19 and healthcare impacts
- Prion Diseases and Protein Misfolding
- Genetics and Neurodevelopmental Disorders
- Prosthetics and Rehabilitation Robotics
- Muscle activation and electromyography studies
- Genomic variations and chromosomal abnormalities
- Congenital Diaphragmatic Hernia Studies
- RNA regulation and disease
- Corneal surgery and disorders
- Climate Change and Health Impacts
- Parkinson's Disease and Spinal Disorders
- Parkinson's Disease Mechanisms and Treatments
Neurogen Brain & Spine Institute
2015-2024
Government Medical College
2017
Government Medical College and Hospital
2017
Cellular therapy is an emerging therapeutic modality with a great potential for the treatment of autism. Recent findings show that major underlying pathogenetic mechanisms autism are hypoperfusion and immune alterations in brain. So conceptually, cellular which facilitates counteractive processes improving perfusion by angiogenesis balancing inflammation regulation would exhibit beneficial clinical effects patients This open label proof concept study autologous bone marrow mononuclear cells...
Cerebral palsy is a nonprogressive heterogeneous group of neurological disorders with growing rate prevalence. Recently, cellular therapy emerging as potential novel treatment strategy for cerebral palsy. The various mechanisms by which works include neuroprotection, immunomodulation, neurorestoration, and neurogenesis. We conducted an open label, nonrandomized study on 40 cases aim evaluating the benefit in combination rehabilitation. These were administered autologous bone marrow...
Cell therapy is being widely explored in the management of stroke and has demonstrated great potential. It been shown to assist remodeling central nervous system by inducing neurorestorative effect through process angiogenesis, neurogenesis, reduction glial scar formation. In this study, intrathecal administration autologous bone marrow mononuclear cells (BMMNCs) analyzed on recovery patients with chronic stroke. 24 diagnosed were administered cell therapy, followed multidisciplinary...
Mesenchymal stem cells can serve as a therapeutic option for COVID-19. Their immunomodulatory and anti-inflammatory properties regulate the exaggerated inflammatory response promote recovery of lung damage.Phase-1, single-centre open-label, prospective clinical trial was conducted to evaluate safety efficacy intravenous administration mesenchymal derived from umbilical cord placenta in moderate The study done 2 stages with total 20 patients. Herein, results stage 1 including first 10...
Cerebral palsy (CP) is one of the non-progressive neurological diseases caused by damage to brain tissue at birth, which leads physical, cognitive and perceptive symptoms. Even after lifelong medical therapeutic management there are residual deficits affect quality life patients their families. We examined a maximally rehabilitated, 20 year old male suffering from CP Mental Retardation (MR). He had diplegic gait Intelligence Quotient (IQ) score 44 with affected fine motor activities,...
Purpose Duchenne muscular dystrophy (DMD) is the most common and severe form of dystrophy. Current diagnostic tests like genetic testing, needle electromyography, muscle biopsy are either not easily available or invasive, they impractical for assessing disease progression treatment outcomes. Therefore, there a need non-invasive accurate investigative modality DMD. In recent years, musculoskeletal magnetic resonance imaging (MRI-MSK) along with fractional anisotropy (FA) diffusion tensor...
In response to acute ischemic stroke, large numbers of bone marrow stem cells mobilize spontaneously in peripheral blood that home onto the site ischemia activating penumbra. But with chronicity, mobilized decrease, reducing degree and rate recovery. Cellular therapy has been explored as a new avenue restore repair process chronic stage. A 67-year-old Indian male right middle cerebral artery stroke had residual left hemiparesis despite standard management. Recovery was slow partial resulting...
[18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography scan was performed on 45 children with autism to study the baseline pattern and age-related developmental changes in brain metabolism. Median standardized uptake values (SUVs) were compared published healthy control data. Results showed that, contrary data, median SUVs decrease linearly increase age. As controls, below 5 years greater metabolism older lower In group, comparison of absolute within different...
Becker’s Muscular Dystrophy (BMD) is a dystrophinopathy manifested as progressive muscle degeneration. Autologous Bone Marrow Mononuclear Cells (BMMNCs) have shown some myogenic potential. The paracrine effects of the BMMNCs reduce inflammation and are thought to We treated 39 year old dental surgeon suffering from BMD. Muscle strength was reduced when measured using modified Medical Research Council’s Manual Testing (mMRC-MMT). Static sitting balance poor. He wheelchair dependent for...
Abstract: Limb girdle muscular dystrophy (LGMD), a group of progressive degenerative disorders, causes functional limitation affecting the quality life. Cell therapy is being widely explored and preliminary studies have shown beneficial effects. induces trophic-factors release, angiogenesis, anti-inflammation, protein synthesis, which helps in reparative process at microcellular level. In this 5-year longitudinal study, effect autologous bone marrow mononuclear cells studied on natural...
Becker muscular dystrophy (BMD) is an inherited disorder due to deletions of the dystrophin gene that leads muscle weakness. Effects bone marrow mononuclear cell (BMMNC) transplantation in Muscular Dystrophy have shown be safe and beneficial. We treated a 20-year-old male suffering from BMD with autologous BMMNC followed by multidisciplinary rehabilitation. He presented weakness had difficulty performing his activities. The BMMNCs were transplanted via intrathecal intramuscular routes....
Promising results from previous studies using cell therapy have paved the way for an innovative treatment option amyotrophic lateral sclerosis (ALS). There is considerable evidence of immune and inflammatory abnormalities in ALS. Bone marrow mononuclear cells (BMMNCs) possess immunomodulatory properties could contribute to slowing disease progression. Aim our study was evaluate long-term effect autologous BMMNCs combined with standard on survival duration a large population type onset...
Bone marrow mononuclear cells (BMMNCs) have emerged as a potential therapeutic strategy for various incurable conditions including autism spectrum disorder (ASD). To study its safety and efficacy, we analyzed 1011 patients who underwent intrathecal administration of autologous BMMNCs along with neurorehabilitation. At mean follow-up 19.3 months after intervention, 90.6% showed overall improvement. Improvements were observed in attention concentration, command following, eye contact, sitting...
Cell therapy, along with intensive rehabilitation has been shown to significantly improve outcomes in amyotrophic lateral sclerosis (ALS), addition standard therapy. We present a 40-years-old male ALS patient, suffering for the past four years, who underwent multiple doses of cell therapy at our institution. Along riluzole treatment and lithium co-administration, his involved intrathecal transplants autologous bone marrow-derived mononuclear cells, followed by multidisciplinary...
Introduction: Ischemic stroke is brain injury due to hypoperfusion leading sudden neurological symptoms. Despite advances in medicine, prognosis still grim especially with chronic residual neurodeficits. Autologous bone marrow mononuclear cells (BMMNCs) transplantation safe and has shown positive outcomes previous studies of ischemic stroke. Our aim was study the effect autologous BMMNCs Intervention Results: We treated a case pontine infarct three years later, followed by standard...
Becker's Muscular dystrophy (BMD) is a disorder with progressive course of muscle weakness leading to disability and premature death.Pharmacological rehabilitative management supportive does not halt the progression disease.Novel treatment options gene therapy stem cell may provide promising solution by altering basic pathology disease.Pre-clinical studies have shown safety beneficial effects bone marrow derived mononuclear cells transplantation in BMD.In this case report, we treated patient...
Various cellular therapies are being increasingly investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease with selective loss anterior horn cells. Lithium is known to enhance potency transplanted cells, while well tolerated by ALS patients. Additionally, rehabilitation significantly improves outcomes in various disorders. We present 47-year-old male patient suffering from 2 years, whose involved intrathecal transplantation autologous...
50 eyes of patients with pseudoexfoliation syndrome were studied in order to note incidence different intraoperative complications during cataract surgery, early postoperative and best corrected visual acuity (BCVA) also the measures minimize complications. Our study concluded that is commonly seen old age, usually a bilateral condition male predominance. Pseudoexfoliation leads difficulty achieving adequate pupil dilatation thus various poor outcome after surgery. Thus detailed preoperative...