A5072979571- Bone Tissue Engineering Materials
- Salivary Gland Disorders and Functions
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Laser Applications in Dentistry and Medicine
- Genomics, phytochemicals, and oxidative stress
- Graphene and Nanomaterials Applications
- Head and Neck Cancer Studies
- 3D Printing in Biomedical Research
- Synthesis and biological activity
- Corneal Surgery and Treatments
- Blood transfusion and management
- Galectins and Cancer Biology
- Ion Transport and Channel Regulation
- Glutathione Transferases and Polymorphisms
- Bone and Dental Protein Studies
- Bone health and treatments
- Sexual function and dysfunction studies
- Immune Response and Inflammation
- Medical and Biological Ozone Research
- Oral health in cancer treatment
- Bioactive Compounds and Antitumor Agents
- FOXO transcription factor regulation
- Facial Trauma and Fracture Management
Mansoura University
2018-2024
McGill University
2018-2022
Abstract Head and neck squamous cell carcinoma (HNSCC) has a poor 5-year survival rate of 50%. One potential reason for treatment failure is the presence cancer stem cells (CSCs). Several markers, particularly CD44, have been used to isolate CSCs. However, isolating pure population CSC in HNSCC still remains challenging task. Recent findings show that normal oral were isolated using CD271 as marker. Thus, we investigated combined use CD44 an enriched subpopulation CSCs, followed by their...
Sjogren’s syndrome (SS) is an autoimmune disease that manifests primarily in salivary and lacrimal glands leading to dry mouth eyes. Unfortunately, there no cure for SS due its complex etiopathogenesis. Mesenchymal stem cells (MSCs) were successfully tested SS, but some risks limitations remained their clinical use. This study combined cell- biologic-based therapies by utilizing the MSCs extract (MSCsE) treat SS-like NOD mice. We found MSCsE successful comparable preserving function mice...
Reinforced extracellular matrix (ECM)-based hydrogels recapitulate several mechanical and biochemical features found in the tumor microenvironment (TME) vivo. While these gels retain critical structural bioactive molecules that promote cell–matrix interactivity, their properties tend toward viscous regime limiting ability to ordered characteristics when considered as architectured scaffolds. To overcome this limitation characteristic of pure ECM hydrogels, we present a composite material...
Temporomandibular joint (TMJ) arthritis is a debilitating, challenging condition and different methods have been implicated for its treatment. This study aimed to test the therapeutic potentials of low-level laser therapy (LLLT) associated with adipose derived stem cells (ADSC) or their secretome on murine model induced arthritis.Forty eight rats were divided into four groups where group I was sham control, rest animals subjected induction using complete Freund's adjuvant, then as follows:...
Abstract Background Head and neck squamous cell carcinomas (HNSCC) are malignant neoplasms with poor prognosis. Treatment-resistant cancer stem (CSC) is one reason for treatment failure. Considerable attention has been focused on sulforaphane (SF), a phytochemical from broccoli possessing anticancer properties. We investigated whether SF could enhance the chemotherapeutic effects of cisplatin (CIS) 5-fluorouracil (5-FU) against HNSCC–CSCs, its mechanisms action. Methods CD44 + /CD271...
Abstract Objectives The human salivary gland ( HSG ) cell line, labeled as a submandibular ductal is commonly used in vitro models to study radiation therapy, Sjögren's syndrome, pleomorphic adenoma, mucocele, epithelial‐to‐mesenchymal transition, and epigenetics. However, the American Type Culture Collection ATCC has recently released list of cross‐contaminated lines that included . Despite this notice, some research laboratories still use model. Therefore, examined authenticity sampled...
Stem cell–based therapies could provide a permanent treatment for salivary gland (SG) hypofunction caused by ionizing radiation (IR) injury. However, current challenges SG stem cells to reach the clinic include surgical invasiveness, amount of tissue needed, cell delivery, and storage methods. The objective this study was develop clinically less invasive method isolate expand human then obtain cell-free extract be used as therapy IR-injured SGs. Human labial glands were biopsied, (LSCs)...
Abstract Aim Platelet‐rich plasma (PRP) is an autologous blood‐derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed assess the effect of changes in leucocyte and PRP (L‐PRP) composition on defect healing. Materials Methods L‐PRPs were prepared using different centrifugation methods their regenerative potential was assessed in‐vivo rat model. Bilateral critical‐size tibial defects created filled with...
Mitigation of irradiation injury to salivary glands was previously reported using a cell-free extract from mouse bone marrow. However, bring this potential therapy step closer clinical application, human marrow cell (BMCE) needs be tested. Here, we report that irradiation-induced in immunocompetent mice treated with BMCE secreted 50% more saliva than saline-injected mice, and did not cause additional acute inflammatory reaction. In addition, identify the fraction most therapeutic activity,...
Nacre has an excellent combination of strength and toughness due to its "brick-and-mortar" layered structure. Graphene oxide (GO) is ideal candidate as a "brick" material two-dimensional structure, outstanding ultimate strength, Young's modulus. GO also able stimulate osteogenesis, which suggests the potential application nacre-like GO-based nanocomposites in bone regeneration. Most developed thus far focus on simultaneous enhancement toughness, with only three studies published date...
Polyetheretherketone (PEEK) is a biocompatible material widely used in spinal and craniofacial implants, with potential use percutaneous implants. However, its inertness prevents it from forming tight seal the surrounding soft tissue, which can lead to infections implant failure. Conversely, surface chemistry of organs (i.e., teeth) helps establish strong interaction epithelial cells contacting tissues, hence seal, preventing infection. The created by adsorption basement membrane (BM)...
Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration donepezil on healing remains unknown. Therefore, this study aimed assess impact injection healing, titanium-implant osseointegration, soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned receive a daily dose either (0.6 mg/kg) or saline as...
Objective: To test the efficacy of low-level laser therapy (LLLT) to alleviate temporomandibular TMJ induced arthritisin rats. Materials and methods: Rats were randomly allocated three groups: group I (sham control), II(arthritis) where animals subjected arthritis induction using complete Freund's adjuvant followed by LLLT (0j/cm2), III (38 j/cm2). One andthree weeks after treatment onset, rats euthanized specimens histological,histomorphometric, histochemical analysis. Results: The sham...
Bioactive glasses are surface-reactive that, when placed in physiological fluid, undergo a transformation from glass to hydroxyapatite. Doping the bioactive with metallic ions can impart desirable and unique properties that not inherent natural Once such ion is titanium. Titanium exists trace amounts native dental enamel, its presence has been correlated increased tooth hardness brightness, both clinical properties. Synthetic titanium-substituted hydroxyapatite exhibits better mechanical...
Most current larynx cancer therapies are generally aimed at the global mass of tumor, targeting non-tumorigenic cells, and unfortunately sparing tumorigenic stem cells (CSCs) that responsible for sustained growth, metastasis, chemo- radioresistance. Phytochemicals herbs have recently been introduced as therapeutic sources eliminating CSCs. Therefore, we assessed anti-tumor effects two herbal ingredients, green tea extract "Epigallocatechin-3-gallate (EGCG)" Honokiol (HNK), on parental or...
Abstract Objective Oral lichen planus carries a risk for malignancy. The pathogenesis of the disease is mediated by various inflammatory mediators. Several mediators could be responsible oncogenic behavior in certain cases. Hypoxia-inducible factor-1a (HIF-1), and its possible correlation to Galactin-3 (Gal-3) matrix metalloproteinase-9 (MMP-9) over expression represents an important indicator malignant transformation. investigation these factors may present evidence-based information on...
The authors wish to make the following corrections this paper [...]