A5016914455- Anesthesia and Pain Management
- Advanced Drug Delivery Systems
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Temporomandibular Joint Disorders
- Osteoarthritis Treatment and Mechanisms
- Advancements in Transdermal Drug Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Oral microbiology and periodontitis research
- Dental Anxiety and Anesthesia Techniques
- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Inflammatory mediators and NSAID effects
- Botulinum Toxin and Related Neurological Disorders
- Orthodontics and Dentofacial Orthopedics
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Drug Solubulity and Delivery Systems
- Anesthesia and Neurotoxicity Research
- NF-κB Signaling Pathways
- Hemodynamic Monitoring and Therapy
- Phytochemistry Medicinal Plant Applications
- Palliative and Oncologic Care
- Antimicrobial Peptides and Activities
Universidade Estadual de Campinas (UNICAMP)
2010-2024
Guarulhos University
2019-2024
East Carolina University
2018
Methodist University of Piracicaba
2017
Universidade Federal do Paraná
2017
Pontifícia Universidade Católica do Paraná
2009-2010
The treatment and control of schistosomiasis, a neglected disease that affects more than 200 million people worldwide, rely on the use single drug, praziquantel. A vaccine has yet to be developed since new drug design development is lengthy costly process, repurposing promising strategy. In this study, efficacy promethazine, first-generation antihistamine, was evaluated against Schistosoma mansoniex vivo in murine model schistosomiasis. vitro assays demonstrated promethazine affected...
Lidocaine is the most commonly used local anesthetic worldwide, known for its rapid onset and moderate duration of anesthesia. However, it short-lived does not effectively promote effective topical anesthesia in oral cavity when alone. Our aim was to investigate whether an approximate 50% encapsulation lidocaine poly(ε-caprolactone) nanocapsules (LDC-Nano) would be able increase permeation analgesic efficacy reduce cytotoxicity. In this study, we characterized LDC-Nano conducted MTT tests...
Current treatments for Candida albicans infection are limited due to the number of antifungal drugs available and increase in resistance. Curcumin is used as a spice, food preservative, flavoring, coloring agent that has been shown have many pharmacological activities. Thus, this study evaluated modulatory effects curcumin on major virulence factors associated with pathogenicity C. albicans. The minimum inhibitory concentration (MIC) against (SC5314) was determined. Biofilm formation...
Abstract Objectives Modified drug delivery systems have been developed to improve pharmacological properties of local anaesthetics. However, the inflammatory potential these formulations was not investigated. This study compared in-vitro effects ropivacaine (ropi) in plain, liposomal (MLV) or 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) on cell viability, apoptosis and cytokine (IL-1α, TNF-α, IL-6 IL-10) release. Methods Human immortalized keratinocytes (HaCaT) human gingival fibroblasts (HGF)...
Introdu��o: O conforto do paciente oncol�gico � comprometido devido aos sintomas e consequ�ncias f�sicas psicol�gicas da doen�a. A musicoterapia se destaca como uma interven��o econ�mica que pode ser utilizada na rotina de cuidados desses pacientes. Objetivo: Identificar os efeitos no oncol�gico. M�todo: Revis�o integrativa literatura, com abordagem qualitativa. Foram inclu�dos artigos completos dispon�veis eletronicamente, escritos nos idiomas portugu�s, ingl�s ou espanhol publicados a...
Recent advances have been reported for needle-free local anesthesia in maxillary teeth by administering a nasal spray of tetracaine (TTC) and oxymetazoline, without causing pain, fear, stress. This work aimed to assess whether TTC-loaded hybrid system could reduce cytotoxicity, promote sustained permeation, increase the anesthetic efficacy TTC safe, effective, painless, prolonged analgesia dental procedures. The based on (4%) encapsulated nanostructured lipid carriers (NLC) incorporated into...
Purpose: This study observed the effect of garlic extracts and amoxicillin against an induced staphylococcal infection model. MIC MBC were also obtained for aqueous Allium sativum (Asa) tuberosum (Atu) Staphylococcus aureus penicillin-sensitive (PSSA - ATCC 25923) MRSA (ATCC 33592). Methods: Granulation tissues in back 205 rats. After 14 days, 0.5 mL 108 CFU/mL PSSA or injected inside tissues. 24h, animals divided: G1 (Control) – NaCl 0.9%; G2 Asa 100 mg/kg 400mg/kg; G3 Atu 400 mg/kg; G4...
The Chronic Constriction Injury of the Infraorbital Nerve (CCI-ION) is a well-established model to study facial sensory changes related trigeminal neuropathic pain. CCI-ION induces heat hypersensitivity that resolves within 2-3 weeks and delayed mechanical emerges during second week post-injury. role descending facilitatory pain pathways from rostro ventromedial medulla (RVM) in mediating tactile was examined. induced observed 5days post-surgery reversed by systemic, but not RVM lidocaine....
Abstract Objectives Squamous cell carcinoma (SCC) is a malignant disease that affects the oral cavity. Lidocaine has shown antiproliferative and cytotoxic activity on several types. The rapid dispersion limitation issue; however, complexation in cyclodextrin improved pharmacological features modified drug release. This study investigated effects of lidocaine (lido) complexed with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD-lido) viability proliferation human tongue squamous SCC9 SCC25. Methods...
To determine whether the permeation capacity and analgesic efficacy of articaine (ATC) could be increased cytotoxicity decreased by encapsulation in poly(ɛ-caprolactone) nanocapsules (ATC nano ), aiming at local or topical anesthesia dentistry. Cellular viability was evaluated (using MTT test fluorescence microscopy) after 1 h 24 exposure HaCaT cells to ATC, ATC , with epinephrine epi nanoepi ). The profiles 2% across swine esophageal epithelium were determined using Franz-type vertical...
The aim of this study was to observe the effect multilamellar liposomes (MLV) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) in in-vitro effects lidocaine cell viability, pro-inflammatory cytokines prostaglandin E2 release both human keratinocytes (HaCaT) gingival fibroblasts (HGF) cells.HaCaT HGF cells were exposed 100-1 μm plain, MLV HP-β-CD formulations for 6 h or 24 h. formulation viability measured by XTT assay fluorescent labelling. Cytokines (IL-8, IL-6 TNF-α) PGE2 quantified ELISA.MLV...
Objectives: Local anesthetics (LAs) cause the loss of sensitivity to nociceptive stimulus by reversible blockade neural electrical impulse. These drugs are widely used for pain control in many clinical procedures and other therapeutic applications. Besides effects on voltage-gated sodium channels, LAs can modulate different cellular pathways. The review seeks address local viability, apoptosis induction inflammatory response. Methods: Data was collected from MEDLINE®, Scopus® Web Science,...