A5034172218- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Antimicrobial Peptides and Activities
- Biochemical effects in animals
- Neurogenesis and neuroplasticity mechanisms
- Sirtuins and Resveratrol in Medicine
Dalian Medical University
2021-2025
Aberrant increases in neuronal network excitability may contribute to cognitive deficits Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability of neurons are not fully understood. Voltage-gated sodium channels (VGSC or Nav), which involved formation excitable cell's action potential and can directly influence neural networks, have been implicated AD-related abnormal hyperactivity higher incidence spontaneous non-convulsive seizures. Here, we shown that reduction VGSC...
Background: Our previous studies have shown that scorpion venom heat-resistant synthesized peptide (SVHRSP) induces a significant extension in lifespan and improvements age-related physiological functions worms. However, the mechanism underlying potential anti-aging effects of SVHRSP mammals remains elusive. Methods: Following treatment senescence-accelerated mouse resistant 1 (SAMR1) or prone 8 (SAMP8) mice, behavioral tests were conducted brain tissues collected for morphological analysis,...
Voltage-gated sodium channels (Nav's), particularly Nav1.6, are crucial for action potential generation in neurons and linked to brain disorders. This study explores the cell-type-specific expression of Nav1.6 C57BL/6 mice brains at various developmental stages. Coronal sections from embryonic day 14 postnatal 30 were examined. increased both protein messenger RNA (mRNA) levels during this period. Immunofluorescence double staining revealed that is primarily localized on neurons. Astrocytes...
Microglia-related inflammation is associated with the pathology of Parkinson's disease. Functional voltage-gated sodium channels (VGSCs) are involved in regulating microglial function. Here, we aim to investigate effects scorpion venom heat-resistant synthesized peptide (SVHRSP) on 6-hydroxydopamine (6-OHDA)-induced disease-like mouse model and reveal its underlying mechanism.Unilateral brain injection 6-OHDA was performed establish disease model. After behaviour test, tissues were collected...
Nav1.6 is closely related to the pathology of Alzheimer's Disease (AD), and astrocytes have recently been identified as a significant source β-amyloid (Aβ). However, little known about connection between astrocyte-derived Aβ. This study explored crucial role in mediated Aβ AD knockdown astrocytic alleviates progression by promoting autophagy lysosome-APP fusion. A mouse model for was constructed effects on amyloidosis. The lysosome-APP(amyloid precursor protein) fusion used transmission...