A5020841128- Neuroscience and Neuropharmacology Research
- Global Maternal and Child Health
- Blood Pressure and Hypertension Studies
- Tryptophan and brain disorders
- Global Public Health Policies and Epidemiology
- Alzheimer's disease research and treatments
- Cancer Immunotherapy and Biomarkers
- Health Policy Implementation Science
- Health Systems, Economic Evaluations, Quality of Life
- Neuroinflammation and Neurodegeneration Mechanisms
- Global Health Care Issues
- Ferroptosis and cancer prognosis
- Genetics, Aging, and Longevity in Model Organisms
- Stress Responses and Cortisol
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Primary Care and Health Outcomes
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Pain Management
- Barrier Structure and Function Studies
- Healthcare Operations and Scheduling Optimization
- Neuropeptides and Animal Physiology
- Neurological Disorders and Treatments
Dalian Medical University
2018-2025
Kwame Nkrumah University of Science and Technology
2014-2025
Kwame Nkrumah University
2024
First Affiliated Hospital of Dalian Medical University
2020
Sigma Theta Tau International
2017
John Wiley & Sons (United States)
2017
Hudson Institute
2017
Background: Immune cells have essential auxiliary functions and influence clinical outcomes in cancer, with high immune infiltration being associated improved better response to treatment breast cancer (BC). However, studies date not fully considered the tumor-infiltrating cell (TIIC) landscape tumors. This study investigated potential biomarkers based on TIICs improve prognosis effect BC. Results: We enrolled 5112 patients for analysis used type identification by estimating relative subsets...
Background Poor access to care and physician shortage are major barriers hypertension control in sub-Saharan Africa. Implementation of evidence-based systems-level strategies targeted at these lacking. We conducted a study evaluate the comparative effectiveness provision health insurance coverage (HIC) alone versus nurse-led task shifting strategy for (TASSH) plus HIC on systolic blood pressure (SBP) reduction among patients with uncontrolled Ghana. Methods findings Using pragmatic cluster...
Nurses in Ghana play a vital role the delivery of primary health care at both household and community level. However, there is lack information on task shifting management control hypertension to nurses low- middle-income countries including Ghana. The purpose this study was assess nurses' knowledge practice pre- post-training utilizing task-shifting strategies for (TASSH). A post- test survey administered 64 (CHNs) enrolled (ENs) employed centers district hospitals before after TASSH...
The details of the immunological microenvironment and its clinical implications for pancreatic cancer are still unclear. In this study, we obtained data from public databases, such as Gene Expression Omnibus, Cancer Genome Atlas Program, International Consortium Data Portal, ArrayExpress Warehouse, cBioPortal Genomics. We used these to evaluate pattern immune cells infiltration in ductal adenocarcinoma (PDAC) tissues. observed that levels M0 macrophages activated dendritic tumor tissues were...
Countries in sub-Saharan Africa (SSA) are experiencing an epidemic of cardiovascular disease (CVD) propelled by rapidly increasing rates hypertension. Barriers to hypertension control SSA include poor access care and high out-of-pocket costs. Although bears 24% the global burden, it has only 3% health workforce. Given such limited resources, cost-effective strategies, as task shifting, needed mitigate rising CVD SSA. Ghana, a country with established community worker program integrated...
Aberrant increases in neuronal network excitability may contribute to cognitive deficits Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability of neurons are not fully understood. Voltage-gated sodium channels (VGSC or Nav), which involved formation excitable cell's action potential and can directly influence neural networks, have been implicated AD-related abnormal hyperactivity higher incidence spontaneous non-convulsive seizures. Here, we shown that reduction VGSC...
Chondroitin sulfate (CS) and dermatan (DS) proteoglycans are major extracellular matrix (ECM) components of the central nervous system (CNS). A large body evidence has shown that CS/DS (CSPG/DSPG) play critical roles in neuronal growth, axon guidance, plasticity developing mature CNS. It been proposed these exert their function through specific interaction chains with its binding partners a manner depends on sulfation patterns CS/DS. However, 4-O-sulfotransferase-1 (Chst14/D4st1) for DS, but...
Background: The incidence of colorectal cancer (CRC) has been increasing worldwide in recent years. Targeting stem cells (CSCs) CRC remains a difficult challenge. KDM2B and EZH2 play important role the maintenance CSCs' self-renewal capacity tumorigenic ability; however, biological functions those genes remain unclear. In this study, we aimed to define contribution expression features establish relationship between CSCs. Methods: specimens cell lines were analyzed by immunohistochemistry,...
Voltage-gated sodium channels (Nav's), particularly Nav1.6, are crucial for action potential generation in neurons and linked to brain disorders. This study explores the cell-type-specific expression of Nav1.6 C57BL/6 mice brains at various developmental stages. Coronal sections from embryonic day 14 postnatal 30 were examined. increased both protein messenger RNA (mRNA) levels during this period. Immunofluorescence double staining revealed that is primarily localized on neurons. Astrocytes...
Long non-coding RNAs (lncRNAs) contribute to disease pathogenesis and drug treatment effects. Both emodin dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated lung injury (SAP-ALI). However, lncRNA regulation networks related SAP-ALI are unreported. In this study, lncRNAs mRNAs in the tissue of control rats, with or without (emodin DEX), were assessed by RNA sequencing. Results showed both DEX therapeutic that mRNA levels differed between untreated treated...
Synaptic plasticity is the neural basis of physiological processes involved in learning and memory. Tripartite motif-containing 32 (TRIM32) has been found to play many important roles brain such as stem cell proliferation, neurogenesis, inhibition nerve apoptosis. TRIM32 linked several nervous system diseases including autism spectrum disorder, depression, anxiety, Alzheimer's disease. However, role regulating mechanism synaptic still unknown. Our electrophysiological studies using...
Abstract Background Postoperative Nausea and Vomiting (PONV) is a dreadful uncomfortable experience that significantly detracts patients’ quality of life after surgery. This study aimed to examine the antiemetic effect single sub-hypnotic dose propofol as prophylaxis for PONV. Method In this prospective, double-blind, randomized control trial, 345 parturients presented elective cesarean section at Obstetric unit Tamale Teaching Hospital were recruited. Each recruited parturient was randomly...
Abstract Background The burden of hypertension in many low-and middle-income countries is alarming and requires effective evidence-based preventative strategies that carefully appraised accepted by key stakeholders to ensure successful implementation sustainability. We assessed nurses’ perceptions a recently completed Task Shifting Strategy for Hypertension control (TASSH) trial Ghana, facilitators challenges TASSH implementation. Methods Focus group sessions in-depth interviews were...
The purpose of this study was to explore stakeholders' perception an on-going evidence-based task-shifting strategy for hypertension (TASSH) in 32 community health centers and district hospitals Ghana.Using focus group discussions in-depth interviews, qualitative data were obtained from 81 key stakeholders including patients, nurses, site directors participating involved the TASSH trial. Qualitative analyzed using open axial coding techniques.Analysis revealed three themes that illustrate...
The use of task-shifting is an increasingly widespread delivery approach for health interventions targeting prevention, treatment, and control hypertension in adults living sub-Saharan Africa (SSA). Addressing a gap the literature, this research examined sustainability ongoing strategy (TASSH) from perspectives community nurses (CHNs) implementing program.We used concept-mapping, mixed-methods participatory to understand CHNs' perceptions barriers enablers sustaining program. Participants...
Alzheimer's disease (AD), being a complex disorder, is affected either by genetic or environmental factors both. It observed that there an excessive accumulation of amyloid β (Aβ) in the extracellular space brain. AD first neurodegenerative elderly, and so far no effective treatment. In recent years, many studies have reported has relationship with gut microflora, indicating regulating microbiota could offer therapeutic intervention for AD. This study explored effect Bifidobacteria averting...
Aquaporin-4 (AQP4) is characterized by the formation of orthogonal arrays particles (OAPs) comprising its M1 and M23 isoforms in plasma membrane. However, biological importance OAP obscure. Here, we developed an depolymerization male mouse model transgenic knock-in AQP4-A25Q mutation. Analyses mutant brain tissue using blue native polyacrylamide gel electrophoresis, super-resolution imaging, immunogold electron microscopy revealed remarkably reduced structures glial endfeet localization...
Aging is associated with physiological and pathological changes presents health complications, such as dementia. Isolation has also been the experience of growing old. Both have linked individually to incidence cognitive decline. In this present study, effects these two phenomena looked at in animal models where aging was induced D(+)Galactose mice who underwent long-term post-weaned social isolation (L-PWSI). Assessing function using Y-maze, Morris water maze (MWM), passive avoidance tests...
Objectives: Currently in Ghana, there is an on-going task-shifting strategy which nurses are trained hypertension management. While this study will provide useful information on the viability of approach, it not clear how patients intervention perceive hypertension, strategy, and its effects blood pressure The objective paper to examine patients' perceptions management context manage control Ghana.Design: Forty-two participating Task Shifting Strategy for Hypertension program (23 males, 19...