Antimicrobial medicine and food packages based on bio-based film containing essential oils have attracted great attention worldwide. However, the controlled release of from these nanocomposites is still a big challenge. In this study, long-term antibacterial nanocomposite composed zein cinnamon oil (CEO) loaded MCM-41 silica nanoparticles was prepared. The CEO into particles via modified supercritical impregnation efficiently with high drug load (>40 wt%). morphologies prepared were...

Biocompatible skin wound dressing materials with long-term therapeutic windows and anti-infection properties have attracted great attention all over the world. The cooperation between essential oil non-toxic or bio-based polymers was a promising strategy. However, inherent volatility chemical instability of most ingredients in oils make sustained pharmacological activity oil-based biomaterials challenge. In this study, kind film nanocomposite loaded patchouli (PEO-FNC) fabricated. PEO-loaded...

Diabetes is a chronic metabolic disease, whereas α-glucosidases are key enzymes involved in the metabolism of starch and glycogen. There long history use mulberry leaf (the Morus alba) as an antidiabetic herb China, we found that chalcomoracin, one specific Diels-Alder adducts leaf, had prominent α-glucosidase inhibitory activity has potential to be substitute for current hypoglycemic drugs such acarbose, which have severe gastrointestinal side effects. In this study, chalcomoracin was...

It is still controversial whether poor aqueous solubility the most primary reason for low oral bioavailability of insoluble drugs. Therefore, in this study, berberine-loaded solid polymeric particles (BPs) varied dissolution profiles with β-cyclodextrin (β-CD) as carrier were fabricated using solution-enhanced dispersion by supercritical fluids (SEDS), and relationship between berberine (BBR) was evaluated. Dissolution property controlled via particle morphology manipulation, which achieved...

ABSTRACT An ultra‐performance liquid chromatography–tandem mass spectrometric (UPLC‐MS/MS) method was developed and validated to determine AV‐45 in rat plasma. After the addition of internal standard benzophenone, plasma samples were pretreated by protein precipitation. Chromatographic separation achieved on an Acquity UPLC BEH C 18 column (50 × 2.1 mm, 1.7 µm) gradient elution at a flow rate 0.4 mL/min. Detection analytes (IS) done tandem spectrometry, operating positive‐ion multiple...

Phytochemical investigation on the plant endophytic fungus Penicillium ferraniaense GE-7 led to isolation of 18 compounds including one new α-pyrone derivative, peniferranige A (1). The structure absolute configuration compound 1 was elucidated by NMR, HRMS, and ECD data. Demethoxyfumitremorgin C (16) meleagrin (17) possessed moderate activities against human lung cancer cell line H1975 with IC50 values 28.52 ± 1.07 13.94 1.92 μM, respectively.

Anti-aging functional foods benefit the elderly. Telomeres are chromosomal ends that maintain genome stability extended by telomerase catalytic subunit TERT. Due to end-replication problem, telomeres shorten after each cell cycle without in most human cells, and eventually enters senescence stage. Natural products can attenuate aging process increasing activity, such as TA-65. However, TA-65 is expensive. Other Chinese natural may achieve comparable effects. Here, we found Rosa roxburghii...

Self-activated multicolor phosphors are being used in more and emerging fields. In order to explore the energy transfer between [NbO 6 ] 7- coordination groups Sm 3+ ions, a series of Ba 3-y y Ta 1-x Nb x Ga 3 Si 2 O 14 samples co-doped with 5+ were prepared this work, changes luminous intensity under condition fixed concentration regulating obtained respectively. By further fitting emission decay curves two conditions, decreasing average lifetime is obtained. Thermal stability tests also...

The development of orally administrated heparin drugs requires a systematic understanding the interaction between and gut flora. in vivo distribution fluorescein-labeled that is by mice was observed using fluorescein microscopy. In addition, stability simulated gastric intestinal fluids, as well vitro degradation flora were detected HPLC. results show mainly distributed gastrointestinal tract mice, exerted structural under condition fluids vitro. However, could be degraded cultured medium...

Nitrogen (N) pulse is a frequent event in agroecosystems caused by fertilization. Understanding the responses of nitrogen metabolisms native crops and invasive weeds to N pulses essential investigating mechanism weeds. A pot experiment was carried out study impacts interspecific competition on metabolism an weed (Amaranthus retroflexus) crop (Glycine max); plants were applied with equal amount three treatments, i.e., sole-summit treatment (SS) only seeding date, double-summit (DS) twice (the...

Abstract A green and efficient strategy was established optimized for target‐oriented extraction, enrichment separation of cadinene sesquiterpenoids from Eupatorium adenophorum Spreng., using the combination supercritical fluid molecular distillation, industrial preparative chromatography first time. The extraction conditions were initially by orthogonal experimental design. Under optimum conditions, contents 9‐oxo‐10,11‐dehydroageraphorone 10 Hβ ‐9‐oxo‐ageraphorone, which 55.00% 6.01%,...

Receptor binding assay is an important drug screening method, which can quickly and inexpensively study the interactions between targeted receptor potential ligands in vitro provide information of relative affinity ligand-receptor. The imaging many radiopharmaceuticals based on highly selective radioligand-receptor binding. technique plays role design receptor-targeting radiopharmaceuticals. Key words: Radiopharmaceuticals; Drug design; Ligand assay; Radioligand

PET is an advanced imaging technology to obtain biological, physiological or pharmacological function. The signal comprises the sum of a radio-probe and its radioactive metabolites from intracellular, extracellular intravascular compartments given tissue, it cannot provide chemical composition radioactivity radio-labeled substances present. On other hand, in vivo microdialysis powerful sampling technique wherein regional information obtained by implanting probe into fluid interest tissue....