Reactive oxygen species participate in many physiological processes of the body, but their excess disturbs metabolic balance and leads to an unfavorable phenomenon called oxidative stress. Several mechanisms account for ROS elimination. One antioxidants may be phenothiazine derivatives because basic chemical structure – ring. The study aimed assess antioxidant activity prochlorperazine dimaleate, a derivative, compare it with reference (Trolox ascorbic acid). Thus, we investigated ABTS,...

Babesiosis is perceived mainly an animal disease; however, awareness that Babesia spp. parasites can cause diseases in humans increasing significantly. spread by the bite of infected tick (Ixodes spp.), but it also be transmitted transfusion blood and from mother to her child during pregnancy or childbirth. The multiply bloodstream destroy red cells. This study aimed assess influence microti on histological structure placenta. Histopathological material collected pregnant rats with was used...

Ovarian cancer has the worst prognosis among all gynecological cancers. Therefore, it seems reasonable to seek new drugs that may improve effectiveness of treatment or mitigate adverse effects chemotherapy. Caffeic acid phenethyl ester (CAPE) many beneficial biological properties. The aim study was assess anticancer properties CAPE against serum ovarian carcinoma cells. morphology cells evaluated in H-E staining and transmission electron microscopy. cytotoxic proapoptotic activity...

Caffeic acid phenethyl ester (CAPE) belongs to the phenols found in propolis. It has already shown strong antiproliferative, cytotoxic and pro-apoptotic activities against head neck cancers breast, colorectal, lung leukemia cancer cells. Ovarian is one of most dangerous gynecological cancers. Its treatment involves intensive chemotherapy with platinum salts paclitaxel (PTX). The purpose this study was evaluate whether combined use CAPE increases effectiveness chemotherapeutic agents....

Some NK cell subpopulations may be involved in the modulation of fibrogenesis liver. The aim study was to evaluate relationship between number and phenotype subsets peripheral blood (PB) total percentage, population density degree liver fibrosis patients infected with hepatitis C virus (HCV+). group consisted 56 HCV+ patients, divided into two subgroups: mild or moderate advanced cirrhosis (F ≥ 3 METAVIR classification). preparations were stained H-E AZAN staining. cells targeted anti-CD56...

Prostate cancer is a common in men older age groups. The WHO forecasts an increase the incidence of prostate coming years. Patients may not respond to treatment, and tolerate side effects chemotherapy. Compounds natural origin have long been used prevention treatment cancer. Flavonoids obtained from products, e.g., propolis, are compounds with proven antibacterial antiviral efficacy which modulate immune response be useful as adjuvants main aim present study was evaluate cytotoxic...

Babesiosis is a tick-borne disease with an increasing number of cases each year. Due to the non-specific symptoms babesiosis, insightful analyses pathogenesis babesiosis are still very important. Transmission occurs in few ways, which makes laboratory diagnosis piroplasmosis Complications associated infection can be tragic, especially patients immunological disorders. The aim this study was histopathological analysis spleen and kidney young Wistar rats infected transplacentally Babesia...

Pochodne fenotiazyny należą do dobrze znanej grupy leków przeciwpsychotycznych, posiadających wiele nowych aktywności biologicznych, w tym działanie przeciwnowotworowe. Istnieje doniesień naukowych na temat działania przeciwnowotworowego wobec ludzkich linii komórkowych glejaka wielopostaciowego. Niestety, jak dotąd nie przeprowadzono badań <i>in vitro</i> oceniających wpływ fenotiazyn żywotność astrocytów. Można jednak znaleźć badanie dotyczące żywotności neuronów i z komórkami...

Liver fibrosis is a pathological process in which excessive deposition of connective tissueoccurs the liver. It response to chronic liver damage caused by viral agents, alcoholabuse, drug abuse, or autoimmune diseases. Diagnosis and assessment fibrosisare important staging disease, prognosticating its progression, making treatmentdecisions. The diagnosis involves clinical interview, laboratory tests, imaging, – “gold diagnostic standard” histopathological examination. Biopsyingthe allows for...

Abstract Introduction: The aim of the study was to assess influence α-lipoic acid (ALA) on morphology aorta and liver rabbits fed high fat diet with addition oxidised (ORO) non-oxidised rapeseed oil (N-ORO). Material Methods: conducted male chinchilla divided into six groups. control group (C) a breeding standard (BSD), I received BSD ALA in dose 10 mg/kg b.w., groups II III enriched 10% N-ORO or ORO, whereas from IV V ORO ALA. Results: Addition caused necrosis steatosis hepatocytes, as well...

Wstęp Flawonoidy należą do fitoterapeutyków o szerokim spektrum działania farmakologicznego. Udowodniono, że flawonoidy posiadają właściwości mogące hamować rozwój choroby nowotworowej poprzez wywoływanie w komórkach procesu programowanej śmierci komórki. Celem pracy było wykazanie apoptotycznych, antyproliferacyjnych oraz cytotoksycznych wybranych flawonoidów. Materiał i metody badań stanowiła ludzka linia komórkowa pierwotnego raka wątrobowokomórkowego. Badane związki poddano ocenie...

Introduction. Fluorine belongs to xenobiotics that cause disorders in the oxidative-reducting system. Recent studies with fluoride concern use of natural products containing vitamins or antioxidant prevent oxidative stress generated by exposure fluoride. Aim. The aim research was evaluate impact resveratrol and α-lipoic acid on cytotoxicity relative human lung fibroblasts IMR-90. Material methods. In order determine fluorine IMR-90, cells were cultured different NaF concentrations: 30, 60,...

Abstract Human babesiosis is a disease reported mainly in North America, while its etiopathogenesis Europe less frequently described. However, according to the literature, human caused not only by Babesia divergens , as previously thought, but also microti . Babesiosis parasitemia with varied symptoms, and potentially different organs can become dysfunctional during this disease. Since B. penetrates blood infection, liver seems be particularly exposed these parasites, especially first phase...