A5088630779- Asymmetric Synthesis and Catalysis
- X-ray Diffraction in Crystallography
- Asymmetric Hydrogenation and Catalysis
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Ferrocene Chemistry and Applications
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Metal complexes synthesis and properties
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Covalent Organic Framework Applications
- Advanced Photocatalysis Techniques
- Organometallic Complex Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Peptidase Inhibition and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical synthesis and alkaloids
- Luminescence and Fluorescent Materials
- Fluorine in Organic Chemistry
- Neuropeptides and Animal Physiology
- Innovative Microfluidic and Catalytic Techniques Innovation
Universidad Autónoma de Madrid
2016-2025
ORFEO-CINQA Research Network
2022
University of Guayaquil
2019
Institute of Inorganic Chemistry of the Slovak Academy of Sciences
2019
MODUL University Dubai
2019
Instituto de Química Médica
2009-2013
Consejo Superior de Investigaciones Científicas
2012
National Research Council
2010
Aarhus University
2006-2009
Danish National Research Foundation
2006-2008
The catalyst system formed by Cu(CH3CN)4ClO4 and the planar chiral P,S-ligand Fesulphos behaves as a very efficient Lewis acid in catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides. This shows remarkable reactivity at low loading (0.5-3 mol %), affording good yields endo adducts with exceptional levels enantioselectivity (up to >99% ee). procedure has broad structural scope regard both dipolarophile substitution. first examples ketimine-derived azomethines are reported.
As easy as pouring! Three CC bonds, up to three stereocenters, and ee values greater than 97 % are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS=trimethylsilyl; EWG=electron-withdrawing group). Very high enantioselectivity, control of the substituents, handling, user-friendly conditions key features this transformation. Supporting information for article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604479_s.pdf or from author....
It is shown that racemic oxazolones are excellent reagents for the synthesis of chiral quaternary amino acids and its derivatives by diastereo- enantioselective nucleophilic addition to α,β-unsaturated aldehydes catalyzed diarylprolinol silyl ethers. The scope this new organocatalytic reaction demonstrated different having aromatic alkyl groups at reactive carbon atom aliphatic substituted aldehydes, which stereoselective proceeds with good yield, moderate very high diastereoselectivity,...
Quinone pro quo: The organocatalytic enantioselective α-arylation of aldehydes using quinones as the aromatic partner was carried out. reaction proceeds well H2O or EtOH/H2O mixtures solvent. corresponding optically active α-arylated are obtained in high yields and with excellent enantioselectivities (see scheme; TMS: trimethylsilyl). Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701207_s.pdf from author. Please note:...
A new catalytic system for the photooxidation of sulfides based on Pt(<sc>ii</sc>) complexes is presented.
Simply complex: An organocatalytic tandem Michael/Morita–Baylis–Hillman reaction has been developed in which secondary amine catalysts allow for a very selective, scalable synthesis of highly substituted optically active cyclohexanones (see scheme, TMS=trimethylsilyl). Mechanistic studies indicate an role the catalyst Morita–Baylis–Hillman reaction.
Mischen und fertig! Drei C-C-Bindungen bis zu drei Stereozentren entstehen in einer neuen organokatalytischen Mehrkomponenten-Dominoreaktion mit über 97 % ee (siehe Bild; TMS=Trimethylsilyl; EWG=elektronenziehende Gruppe). Die hohe Enantioselektivität ein definiertes Substitutionsmuster sind die Markenzeichen dieser anwenderfreundlichen Reaktion.
An easy and simple synthetic approach to optically active alpha,alpha-quaternary alpha-amino acids using asymmetric organocatalysis is presented. The addition of oxazolones nitroalkenes catalyzed by thiourea cinchona derivatives provides the corresponding acid with good yields, excellent diastereoselectivities (up 98 % dr), from moderate enantioselectivities 92 ee). reaction can be performed on a large scale. oxazolone-nitroalkene products opened in one-pot ester-amide derivatives....
Abstract Photochemistry of extended polyimine COF structures with laminar, spherical and 3D architectures has been examined. We show that these materials, composed by undecorated phenyl rings imine fragments, can act as photocatalyts in oxidative transformations, being the crystalline laminar material most active photocatalyst. The sulfoxidation reaction proceeds good yields for a large variety different sulfides. This process was carried out under visible light conditions (20 W), ethanol/H...
Abstract The asymmetric synthesis of tricyclic compounds by the desymmetrization cyclohexadienones is presented. reaction tolerated a large variety substituents at different positions cyclohexadienone, and heterocyclic rings sizes were accessible. Density functional theory calculations showed that proceeds through an asynchronous [4+2] cycloaddition.
The synthesis of a wide structural variety enantiopure 1-phosphino-2-sulfenylferrocene ligands 1 possessing exclusively planar chirality is described. In the case readily available tert-butylsulfenyl derivatives very high enantioselectivities were obtained in palladium-catalyzed allylic substitution 1,3-diphenyl-2-propenyl acetate with dimethyl malonate (ee's up to 97%) and nitrogen nucleophiles 99.5%). Palladium complexes these ferrocenes characterized by NMR X-ray diffraction, revealing...
The air-stable and readily available cationic methyl palladium(II) complexes of planar chiral Fesulphos ligands [(Fesulphos)Pd(Me)(PhCN)]+ X- are highly efficient catalysts for the alkylative ring opening oxa- azabicyclic alkenes with dialkylzinc reagents, showing broad scope regards to both bicyclic substrate reagent. Catalyst loading as low 0.5 mol % is sufficient achieve good yields enantioselectivities ranging 94 --> 99% ee in most cases. {Fesulphos = (1-phosphino-2-sulfenylferrocene);...
The first direct organocatalytic enantioselective phosphonylation of α,β-unsaturated aldehydes with phosphite, in combination a Brønsted acid and nucleophile, is presented. Mechanistic investigations have revealed that the step catalytic process, after formation iminium intermediate, addition phosphite to β-carbon atom, leading phosphonium ion−enamine intermediate. rate-determining for reaction transformation P(III) P(V), which occurs via nucleophilic SN2-type dealkylation, screening various...
Open plan: Cationic methylpalladium(II) complexes of planar chiral Fesulphos ligands (Fesulphos=1-phosphanyl-2-sulfenylferrocene) show excellent performance in the alkylative ring opening oxa- and azabicyclic alkenes with dialkyl zinc reagents (see scheme, Cy=cyclohexyl, ArF=3,5-bis(trifluoromethyl)phenyl). Catalyst loadings as low 0.5 mol % are normally sufficient to achieve high enantioselectivities (94–>99 ee).
In this communication, we present the synthesis of new platinum complexes based on hydroxyquinoline ligands. We demonstrate importance and role halogen substitution as well chelation, which are essential structural characteristics for finding good cytotoxicities.
A bifunctional photoaminocatalyst based on imidazolidinone and thioxanthone is presented. The preparation of these catalysts proceeds in a two-step synthesis that allows an easy tuning the steric properties. photophysical electrochemical data photocatalysts have been determined, indicating can work under visible light conditions. To corroborate experimental observations, ground state geometry optimization energy transition studies catalyst 4c were optimized by time-dependent density...
In this work, we investigated the response of metal-organic framework MIL-125-NH2 to ball-milling. Both localised and bulk analyses revealed prolongued ball-milling results in a complete loss long-range structural order. Investigation disorder partial retention local bonding secondary building unit, suggesting structure collapse progressed primarily through metal-linker bond breakage. We explored photocatalytic performance materials, examined materials' band gap using UV-Vis reflectance spectroscopy.
Metal–organic framework (MOF) composites are proposed as solutions to the mechanical instability of pure MOF materials. Here, we present a new compositional series recently discovered MOF–crystalline inorganic glass composites. In this case, formed by combination photocatalytic titanium (MIL-125-NH2) and phosphate-based (20%Na2O–10%Na2SO4–70%P2O5). This family has been synthesized characterized using powder X-ray diffraction, thermal gravimetric analysis, differential scanning calorimetry,...
A simple and modulable access to a structural variety of enantiopure amino-substituted ferrocenyl sulfoxides their use as chiral catalysts in the asymmetric addition diethylzinc aromatic aldehydes is described. Moderate high enantioselectivities (up 96% ee) were obtained case arylsulfonamide ligands (R(Fc), R(S))-4h R(S))-4i. It has been demonstrated that planar chirality ferrocene unit decisive element involved reaction.