A5107979568- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Radical Photochemical Reactions
- Advanced Polymer Synthesis and Characterization
- Sulfur-Based Synthesis Techniques
- Polymer Science and PVC
- Polymer crystallization and properties
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Rheology and Fluid Dynamics Studies
- Crystallography and molecular interactions
- Polymer Nanocomposites and Properties
- Covalent Organic Framework Applications
- Material Dynamics and Properties
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- Advanced Photocatalysis Techniques
- Synthesis and Catalytic Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Phase Equilibria and Thermodynamics
- Polymer Foaming and Composites
- Organic Chemistry Cycloaddition Reactions
- Adsorption, diffusion, and thermodynamic properties of materials
Universidad Autónoma de Madrid
2016-2025
ORFEO-CINQA Research Network
2022-2024
Institute for Advanced Medical Research
2017-2021
MODUL University Dubai
2019-2020
Universidad de Las Palmas de Gran Canaria
2010-2017
Instituto de Ciencia y Tecnología de Polímeros
1990-1992
Consejo Superior de Investigaciones Científicas
1990
The most significant contributions towards enantioselective photocatalysis have been described with a special emphasis on the various activation strategies.
The functionalization of an imine-based layered covalent organic framework (COF), containing phenanthroline units as ligands, has allowed the obtention a heterobimetallated material. Photoactive Ir and Ni fragments were immobilized within porous structure COF, enabling heterogeneous light-mediated Csp3–Csp2 cross-couplings. As radical precursors, potassium benzyl- alkoxy-trifluoroborates, silicates, proline derivatives employed, which brings out good versatility Ir,Ni@Phen-COF. Moreover, in...
Among the different alternatives for catalysis using metal–organic frameworks (MOFs) or covalent organic (COFs), photocatalysis has remarkably evolved during last decade. Photocatalytic reticular materials allowed recyclability and easy separation of catalyst from product, also reaching activity selectivity commonly observed molecular systems. Recently, photocatalytic MOFs COFs have been applied to synthetic applications in order obtain molecules complexity. However, although a good number...
An organocatalytic strategy for the synthesis of tetrasubstituted pyrrolidines with monoactivated azomethine ylides in high enantiomeric excess and excellent exo/endo selectivity is presented. The key to success intramolecular activation via hydrogen bonding through an o-hydroxy group, which allows dipolar cycloaddition take place presence bearing only one activating group. bond ylide intermolecular catalyst have been demonstrated by DFT calculations mechanistic proofs be crucial reaction proceed.
The photocatalyzed synthesis of sulfoxides from alkenes and thiols has been carried out using Eosin Y. This is a metal-free method which uses low catalyst loading, atmospheric oxygen as the oxidant, visible light conditions (green light). A mechanism proposed that consistent with experimental results.
The reactivity and the regioselective functionalization of silyl–diene enol ethers under a bifunctional organocatalyst provokes dramatic change in regioselectivity, from 1,5- to 1,3-functionalization. This variation makes possible 1,3-addition silyl–dienol nitroalkenes, giving access synthesis tri- tetrasubstituted double bonds Rauhut–Currier type products. process takes place smooth conditions, nonanionic with high enantiomeric excess. A rational mechanistic pathway is presented based on...
The innate electrophilicity of imine building blocks has been exploited in organic synthetic chemistry for decades. Inspired by the resurgence photocatalysis, reactivity now redesigned through generation unconventional and versatile radical intermediates under mild reaction conditions. While novel photocatalytic approaches have broadened range applicability conventional additions to acceptors, possibility use these imines as latent nucleophiles via single-electron reduction also uncovered....
Three materials containing a photoactive unit, 10-phenyl phenothiazine (PTH), have been studied for the visible light-mediated oxidative coupling of amines. In particular, considered are assembled through condensation extended polyimine, polyhydrazone, or polytriazine frameworks. These three present different stabilities in presence strong nucleophiles such as amines, which is key factor efficient catalytic performance. series reported herein, triazine-based material shows optimal compromise...
In this communication, a new photocatalytic strategy for the addition of alkyl-radical derivatives to N-sulfinimines with complete diastereoselectivity and moderate good yields is presented. This first asymmetric under visible light irradiation smooth conditions functional group tolerance.
A bifunctional photoaminocatalyst based on imidazolidinone and thioxanthone is presented. The preparation of these catalysts proceeds in a two-step synthesis that allows an easy tuning the steric properties. photophysical electrochemical data photocatalysts have been determined, indicating can work under visible light conditions. To corroborate experimental observations, ground state geometry optimization energy transition studies catalyst 4c were optimized by time-dependent density...
The first asymmetric α-trifluoromethylthiolation of 2-substituted isoxazolidin-5-ones was developed using Maruoka type N-spiro ammonium catalysts under phase-transfer conditions. resulting products, containing a trifluoromethylthiolated quaternary chiral carbon, were obtained in moderate to good yields and up 98:2 enantiomeric ratio. Moreover, the easy N-O bond cleavage provided access undescribed α-trifluoromethylthio-β2,2-amino acids, with promising applications biochemistry medicinal chemistry.
An asymmetric aminocatalytic activation strategy to obtain enantioenriched cyclobutanes through [2 + 2] photocycloaddition under visible light irradiation is presented. This metal-free process does not require the use of any external photocatalyst, as it catalyzed by a simple diamine which, upon condensation with an enone substrate, forms iminium ion intermediate that absorbs in region. The direct excitation such leads charge transfer (CT) excited state unlocks stereocontrolled...
The current study presents a direct CF<sub>2</sub>H radical addition to CN bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate, achieving impressive structural diversity.
Herein, we report, a general, facile and environmentally friendly Minisci-type alkylation of
Aryl radical generation and manipulation constitutes a long-standing challenge in organic synthesis. Photocatalytic single-electron reduction of aryl halides has been established as premier activation pathway to reach these intermediates. The current study integrates the conceptual simplicity classical intramolecular homolytic substitution with practicality modern photocatalytic approach. Predicated on an efficient metal-free dehalogenation under mild organo-photoredox conditions, sulfur,...
The encapsulation of an organic dye, 10-phenylphenothiazine (PTH), in the inner cavity single-walled carbon nanotubes (SWNTs) as a breaking heterogenization strategy is presented. PTH@oSWNT material was microscopically and spectroscopically characterized, showing intense photoemission when illuminated with visible light at nanoscale. Thus, employed heterogeneous photocatalyst single electron transfer dehalogenation reactions under irradiation. showed enhanced photocatalytic activity,...
In this work, we investigated the response of metal-organic framework MIL-125-NH2 to ball-milling. Both localised and bulk analyses revealed prolongued ball-milling results in a complete loss long-range structural order. Investigation disorder partial retention local bonding secondary building unit, suggesting structure collapse progressed primarily through metal-linker bond breakage. We explored photocatalytic performance materials, examined materials' band gap using UV-Vis reflectance spectroscopy.
Metal–organic framework (MOF) composites are proposed as solutions to the mechanical instability of pure MOF materials. Here, we present a new compositional series recently discovered MOF–crystalline inorganic glass composites. In this case, formed by combination photocatalytic titanium (MIL-125-NH2) and phosphate-based (20%Na2O–10%Na2SO4–70%P2O5). This family has been synthesized characterized using powder X-ray diffraction, thermal gravimetric analysis, differential scanning calorimetry,...