A5068404187- Organometallic Compounds Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Metal complexes synthesis and properties
- Mesoporous Materials and Catalysis
- Nanomaterials for catalytic reactions
- Nanoplatforms for cancer theranostics
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Advanced Photocatalysis Techniques
- Ferrocene Chemistry and Applications
- Polyoxometalates: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- TiO2 Photocatalysis and Solar Cells
- Corrosion Behavior and Inhibition
- Bone Tissue Engineering Materials
- Catalytic Cross-Coupling Reactions
- Marine Biology and Environmental Chemistry
- Enzyme function and inhibition
- Bone health and treatments
- Advanced biosensing and bioanalysis techniques
- Synthesis and biological activity
- Catalytic C–H Functionalization Methods
- Catalytic Processes in Materials Science
- Photodynamic Therapy Research Studies
- Free Radicals and Antioxidants
Universidad Rey Juan Carlos
2017-2025
Institute of Oncology Prof. Dr. Ion Chiricuta
2020-2021
Instituto de Química y Fisicoquímica Biológicas
2018
Three different multifunctional nanosystems based on the tethering onto mesoporous silica nanoparticles (MSN) of fragments such as an organotin-based cytotoxic compound Ph3Sn{SCH2CH2CH2Si(OMe)3} (MSN-AP-Sn), a folate fragment (MSN-AP-FA-Sn), and enzyme-responsive peptide able to release metallodrug only inside cancer cells (MSN-AP-FA-PEP-S-Sn), have been synthesized fully characterized by applying physico-chemical techniques. After that, in vitro deep determination therapeutic potential...
Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers fields medicine. The present work is focused on the synthesis MSNs containing a maleamato ligand (MSN-maleamic) subsequent coordination copper(II) ions (MSN-maleamic-Cu) for exploration their application antibacterial agents. Cu-containing characterized by techniques preliminary effect supported...
Cancer is the leading cause of death in developed world. In last few decades, photodynamic therapy (PDT) has augmented number medical techniques to treat this disease clinics. As pharmacological active species kill cancer cells are only generated upon light irradiation, PDT associated with an intrinsic first level selectivity. However, since agents also accumulate surrounding, healthy tissue and it practically very challenging expose tumor site light, some side effects can be observed....
A new series of theranostic silica materials based on fibrous particles acting as nanocarriers two different cytotoxic agents, namely, chlorambucil and an organotin metallodrug have been prepared structurally characterized. Besides the combined therapeutic activity, these platforms decorated with a targeting molecule (folic acid, to selectively target triple negative breast cancer) molecular imaging agent (Alexa Fluor 647, enable their tracking both in vitro vivo). The behaviour...
Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disease with no cure to date. Therapeutic agents used treat ALS are very limited, although combined therapies may offer more effective treatment strategy. Herein, we have studied the potential of nanomedicine prepare single platform based on mesoporous silica nanoparticles (MSNs) for an animal model cocktail such as leptin (neuroprotective) and pioglitazone (anti-inflammatory), which already demonstrated promising...
Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and minimum content an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one the most diagnosed aggressive cancerous tumors, very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells luminescent properties detectable by imaging techniques once...
The mechanism of apoptosis triggered by organotin- or titanocene-modified SBA-15 materials has been studied.
Nano-sized materials have shown to very high potential in anticancer therapy by an adequate tuning of their functionalization and physico-chemical properties. This study is focused on the synthesis characterization mesoporous silica nanoparticles (MSN) functionalized with a titanium(IV) or organotin(IV) compound (therapeutic agents), fluorescein isothiocyanate (image agent) transferrin (targeting molecule). The analysis biological activity metallodrug-functionalized systems without has been...
Heterogeneous recyclable catalysts in Suzuki-Miyaura C-C coupling reactions are of great interest green chemistry as reusable alternatives to homogeneous Pd complexes. Considering the interesting properties fluorinated compounds for pharmaceutical industry, precursors novel materials, and also components liquid crystalline media, this present study describes preparation different biphenyl derivatives by catalyzed a heterogeneous system (G-COOH-Pd-10) based on nanoparticles supported onto...
The synthesis, characterization and cytotoxic activity against different cancer cell lines of various mesoporous silica-based materials containing folate targeting moieties a fragment based on triphenyltin(IV) derivative have been studied. Two nanostructured silica systems used: firstly, micronic particles the MSU-2 type and, secondly, nanoparticles (MSNs) about 80 nm. Both series characterized by methods, such as powder X-ray diffraction, fluorescence, absorption spectroscopy microscopy. In...
Abstract Titanium dioxide nanomaterials with improved catalytic and photocatalytic properties through codoping copper fluorine are synthesized contain optimal textural compositional properties, which not possible without doping or a single of Cu F separately. The codoped systems promote the generation synergistic effect increasing activity in processes both potential environmental energy interest. photocatalysts show very effective degradations industrial emerging contaminants such as...
In recent years, titanium dioxide has shown high photocatalytic effectiveness when applied to different decontamination processes. However, the relatively low surface area of this material compared with those other metal oxides limits its adsorption capacity. The modification dioxides carbon species porosity is an excellent option in generating photocatalysts capacity and a promising activation potential. addition, materials may improve electron lifetime TiO2 by decreasing charge...