A5025018110- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Synthetic Organic Chemistry Methods
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Ovarian function and disorders
- Thyroid Disorders and Treatments
- Cyclization and Aryne Chemistry
- Growth Hormone and Insulin-like Growth Factors
- Catalytic Alkyne Reactions
- Hypothalamic control of reproductive hormones
- Regulation of Appetite and Obesity
- Chemical synthesis and alkaloids
- Chemical Reactions and Mechanisms
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Synthesis and Biological Evaluation
- Receptor Mechanisms and Signaling
- Synthesis and biological activity
- Protein Tyrosine Phosphatases
- Adipose Tissue and Metabolism
- Synthesis and Reactions of Organic Compounds
- Chemical Synthesis and Analysis
St Petersburg University
2016-2025
Institute of Evolutionary Physiology and Biochemistry
2017-2025
Saint Petersburg State Forest Technical University
2013
After the appearance of green chemistry concept, which was introduced in vocabulary early 1990s, its main statements have been continuously developed and modified. Currently, there are 10–12 cornerstones that should form basis for an ideal chemical process. This review analyzes accumulated experience achievements towards design products processes reduce or eliminate use generation hazardous substances. The presents views leading Russian scientists specializing various fields this subject,...
Immobilization of palladium(II) acyclic diaminocarbene (Pd(II)-ADC) complexes on a resin support surface has been easily performed by metal-mediated addition amino groups benzhydrylamine-polystyrene to the coordinated isocyanide ligand cis-PdCl2(CNR)2 (R = t-Bu, Cy). The investigation benzhydrylamine reaction with palladium-coordinated isocyanides in solution revealed that, depending conditions, two carbene-type can be obtained as result CN triple bond, well third complex which is formed via...
Metal-mediated coupling between one or two isonitrile ligands in cis-[MCl2(C≡NR)2] [M = Pd, Pt; R 2,6-Me2C6H3 (Xyl), But, cyclohexyl (Cy)] and N-phenylbenzamidine, HN═C(Ph)NHPh, proceeds with different regioselectivity upon varying group. When the aromatic is used (R Xyl), N-phenylbenzamidine coordinated to a metal by HN═C moiety, nucleophilic attack via NHPh center of benzamidine giving [MCl{C(N(Ph)C(Ph)═NH)═NXyl}(C≡NXyl)]. For HN═C(Ph)NHPh center, addition occurs nucleophile afford...
In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are impaired. Metformin the agonists of luteinizing hormone/human chorionic gonadotropin(hCG)-receptor (LH/hCG-R) (hCG, low-molecular-weight allosteric LH/hCG-R-agonists) can be used to restore them. The aim was study effectiveness separate combined administration metformin, hCG 5-amino-N-tert-butyl-2-(methylsulfanyl)-4-(3-(nicotinamido)phenyl)thieno[2,3-d]pyrimidine-6-carboxamide (TP3) on in male rats T2DM. (15...
The approaches to correct thyroid deficiency include replacement therapy with hormones (THs), but such causes a number of side effects. A possible alternative is thyroid-stimulating hormone (TSH) receptor activators, including allosteric agonists. aim this work was study the effect ethyl-2-(4-(4-(5-amino-6-(tert-butylcarbamoyl)-2-(methylthio)thieno[2,3-d]pyrimidin-4-yl)phenyl)-1H-1,2,3-triazol-1-yl) acetate (TPY3m), TSH agonist developed by us, on basal and thyroliberin (TRH)-stimulated TH...
Background: Antithyroid drugs used to treat autoimmune hyperthyroidism lead thyroid hormone deficiency when for a long time. In this regard, it is relevant develop thyroid-stimulating receptor (TSHR) regulators capable of inhibiting TSHR activation by agonists acting on the orthosteric site (TSH, autoantibodies TSHR) and stimulating its basal activity. This function can be performed allosteric with agonist activity negative modulators (ago-NAM).Aim: A comparative study effects TPY4,...
ABSTRACT The inherent benefits of Raman spectroscopy make it a suitable tool for the analysis complex biological objects. Detection and imaging mammalian cells is one its development areas. Plasmonic tags endowed with alkyne reporter intended bioimaging by surface‐enhanced scattering in silent region are presented. Gold nanorods covalently conjugated 4‐aminotolane were obtained using dithiobis (succinimidyl propionate) characterized UV–Vis absorbance, transmission electron microscopy,...
Two types of immobilized on the amino-functionalized polystyrene-supported acyclic diaminocarbene palladium complexes (ADC-PdII) are investigated under Sonogashira cross-coupling conditions. Depending substituents in fragment ADC-PdII, systems found to have different catalytic activity and stability regarding Pd-leaching. PdII-diaminocarbenes possessing protons at both nitrogen atoms smoothly decompose into Pd0-containing species providing a “cocktail system” with high ability reuse within...
Well-defined diazotates are scarce. Here we report the synthesis of unprecedented homoleptic palladium(II) diazotate complexes. The palladium(II)-mediated nitrosylation 2-aminopyridines with NaNO2 results in formation metal-stabilized diazotates, which were found to be cytotoxic human ovarian cancer cells.
Low-molecular-weight agonists of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor (LHCGR), which interact with LHCGR transmembrane allosteric site and, in comparison gonadotropins, more selectively activate intracellular effectors, are currently being developed. Meanwhile, their effects on testicular steroidogenesis have not been studied. The purpose this work is to perform a comparative study the...
Dual inhibitors of protein phosphotyrosine phosphatase 1B (PTP1B)/T-cell (TC-PTP) based on the 3-(hydroxymethyl)-4-oxo-1,4-dihydrocinnoline scaffold have been identified. Their dual affinity to both enzymes has thoroughly corroborated by in silico modeling experiments. The compounds profiled vivo for their effects body weight and food intake obese rats. Likewise, glucose tolerance, insulin resistance, as well leptin levels, evaluated. In addition, PTP1B, TC-PTP, Src homology region 2...
Gonadotropins, including human chorionic gonadotropin (hCG), are used to induce ovulation, but they have a number of side effects, ovarian hyperstimulation syndrome (OHSS). A possible alternative is allosteric luteinizing hormone (LH)/hCG receptor agonists, the compound TP4/2 we developed, which remains active when administered orally. The aim was study effectiveness (orally, 40 mg/kg) as an ovulation inducer in FSH-stimulated immature female rats, compared with hCG (s.c., 15 IU/rat)....
To normalize the thyroid status in hypothyroidism caused by resistance to thyroid-stimulating hormone (TSH), low-molecular-weight allosteric agonists of TSH receptor can be used. A new compound ethyl-2-(4-(4-(5-amino-6-(tert-butylcarbamoyl)-2-(methylthio)thieno[2,3-d]-pyrimidine-4-yl)phenyl)-1H-1,2,3-triazol-1-yl) acetate (TPY3m), which stimulated production thyroxine when administered rats (25 mg/kg, i.p.) and also increased expression thyroidogenic genes cultured FRTL-5 thyrocytes (30 μM)...