A5076293508- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Epilepsy research and treatment
- Cholinesterase and Neurodegenerative Diseases
- Blood Pressure and Hypertension Studies
- Pharmacological Effects and Toxicity Studies
- Long-Term Effects of COVID-19
- Retinal Imaging and Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Neurological Disorders and Treatments
- Renin-Angiotensin System Studies
- Atherosclerosis and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Stroke Rehabilitation and Recovery
- Phosphodiesterase function and regulation
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- Lipoproteins and Cardiovascular Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
Yale University
2022-2025
All India Institute of Medical Sciences
2015-2024
University of Gothenburg
2024
University of California, Los Angeles
2023
B.J. Medical College
2023
Neurology, Inc
2022
World Health Organization
2021
NewYork–Presbyterian Hospital
2021
Institute of Liver and Biliary Sciences
2021
National Institute of Medical Statistics
2021
Galantamine hydrobromide, a promising acetylcholinesterase inhibitor is reported to be associated with cholinergic side effects. Its poor brain penetration results in lower bioavailability the target site. With an aim overcome these limitations, solid–lipid nanoparticulate formulation of galantamine hydrobromide was developed employing biodegradable and biocompatible components. The selected hydrobromide-loaded nanoparticles offered nanocolloidal size than 100 nm maximum drug entrapment...
Early prognostication of patient outcomes in intracerebral hemorrhage (ICH) is critical for care. We aim to investigate protein biomarkers’ role prognosticating ICH patients. assessed 22 biomarkers using targeted proteomics serum samples obtained from the dataset (N = 150). defined poor as modified Rankin scale score 3–6. incorporated clinical variables and regression models random forest-based machine learning algorithms predict mortality. report Odds Ratio (OR) or Hazard (HR) with 95%...
Introduction: Atrial fibrillation (AFib) is a major risk factor for ischemic stroke (IS). AFib diagnosis critical to optimize secondary prevention and reduce the recurrent risk. Objectives: We undertook an exploratory cross-platform proteomics study discover plasma biomarkers of in patients with IS or transient attack (TIA). Methods: used clinical data aged ≥18 years lodged within prospective repository from 2010 2014. collected blood each patient at hospital admission before administering...
Introduction: Rapid stroke diagnosis is critical in the early stages to initiate subtype-specific treatment soon after symptom onset. Objectives: We undertook a cross-platform proteomics study discover plasma biomarkers of emergency room (ER) settings. Methods: analyzed clinical and data from patients aged ≥18 years using prospective repository 2010 2014. Blood samples were collected at admission ER before any therapeutic intervention. Our outcomes differentially expressed protein (DEP)...
Introduction: The National Institutes of Health Stroke Scale (NIHSS) provides a clinical measure stroke severity. Molecular biomarkers that reflect severity neurological injury may enhance the objectivity and accuracy assessment. Objectives: This study aimed to discover plasma proteins indicative in patients with acute ischemic (AIS) using aptamer-based proteomics supervised machine learning algorithms. Methods: We used data AIS aged ≥18 years lodged within prospective repository from 2010...
Introduction: Patients with transient ischemic attack (TIA) and those stroke mimics (MIM) are often difficult to distinguish in emergency room (ER) settings. While TIA patients at an increased risk of stroke, MIM do not need stroke-related management. Biomarkers that from could guide risk-stratification resource utilization acute care. Objectives: We undertook exploratory proteomics study nominate differentially enriched proteins (DEPs) as plasma biomarkers MIM. Methods: Plasma samples were...
The present study investigated the efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in combination with galantamine hydrobromide-loaded solid lipid nanoparticles (GH-SLNs) intracerebroventricular (ICV)-isoproterenol-induced rat model Alzheimer's disease.BM-MSCs were harvested by dissecting femur and tibia 8-10-week-old Wistar rats. 1 × 10(6) administered intravenously once ICV-isoproterenol-induced rats followed GH-SLNs (5 mg/kg) for 3 weeks.ICV-isoproterenol resulted...