A5002541827- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Crystallization and Solubility Studies
- Phytochemicals and Antioxidant Activities
- X-ray Diffraction in Crystallography
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Traditional and Medicinal Uses of Annonaceae
- Drug-Induced Hepatotoxicity and Protection
- Adenosine and Purinergic Signaling
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Ethnobotanical and Medicinal Plants Studies
- Mitochondrial Function and Pathology
- Coconut Research and Applications
- Diabetes and associated disorders
- Advances in Cucurbitaceae Research
- Organometallic Compounds Synthesis and Characterization
- Alzheimer's disease research and treatments
- Seaweed-derived Bioactive Compounds
- Curcumin's Biomedical Applications
- Crystal structures of chemical compounds
- Ginger and Zingiberaceae research
Stellenbosch University
2023-2025
University of Johannesburg
2023
University of KwaZulu-Natal
2018-2023
North-West University
2021-2023
Kogi State University
2014-2015
<b> </b><b> </b>Pumpkin seeds were analysed for their nutritional and anti-nutritional composition, the results obtained were; moisture content (5.00%), ash (5.50%), crude lipid (38.00%, fibre (1.00%), protein (27.48%), Available carbohydrate (28.03%) calorific value (564kcal/100g). Elemental analysis shows that potassium is most abundant element in sample (273mg/100g) manganese least (0.06mg/100g).The parameters are; phytate (35.06 mg/100g), oxalate (0.02±0.10mg/100g), hydrocyanic acid...
Background: Despite “successful” treatment, some lung tuberculosis (TB) patients develop long-term impairments that includes damage to the parenchyma and reduced function, which may predispose them diseases like pulmonary hypertension. However, this is not well understood. Therefore, we investigated whether previous or current TB would display elevated biomarkers of endothelial dysfunction vascular remodeling. Methods: We performed assays for ADMA, VCAM-1, VEGF, angiopoietin-1, TBARS,...
The progression of secondary complications in type 2 diabetes (T2D) has been linked to oxidative stress caused by hyperglycemia. Therefore, the control hyperglycemia is main target treatment diabetes. present study investigated scavenging and ameliorative potentials different fractions Azadirachta indica (A. indica) ethanol stem bark extract Fe2+-induced injury hepatic tissue as well their ability inhibit enzymes enhancing muscle glucose uptake via some vitro ex vivo experimental models....
Vernonia amygdalina leaves were investigated for their histochemical properties and antidiabetic activities. Histochemical analysis of the leaf revealed distributions acidic lipid, mucilage, pectin, lipids, polyphenols, alkaloids at mid rib, glandular trichome, epidermis. HPLC hot water infusion presence quercetin (-)-epi-catechin. The had significant (p < 0.05) 2,2′-diphenyl-1-picrylhydrazyl scavenging activity ferric reducing antioxidant power. Ex vivo antioxidative ability to increase...
Crassocephalum rubens (C. rubens) is a traditional leafy vegetables (TLV) eaten in parts of Africa for the management symptoms diabetes mellitus. This study was done to investigate vivo anti-diabetic activity aqueous extract C. aerial (CRAQ). Type 2 (T2D) induced male Sprague Dawley (SD) rats by feeding them with 10% fructose solution two weeks followed single dose (40 mg/kg body weight) intraperitoneal injection streptozotocin. After confirmation T2D, animals were treated low and high (150...
Chronic hyperglycemia has been implicated in the development of oxidative stress and as a major factor etiology secondary complication diabetes. In present study, antidiabetic potential Phragamenthra incana (P. incana) hot infusion its possible inhibitory effects on carbohydrate digesting enzymes, promotion muscle glucose uptake, antioxidative potentials Fe2+-induced hepatic tissue were investigated. The significantly (p < 0.05) scavenged free radicals (DPPH) displayed favourable ferric...
The presence of natural antioxidant capacity in plants has been well documented world over. There is an increasing demand for to replace synthetic additives the food and pharmacologicals. objective this study evaluate invivo potential ethanol extract Annona muricata against CCl4- induced toxicity rats as its invitro effect lipid peroxidation. was prepared by cold maceration using absolute ethanol. properties determined DPPH (2,2-diphenyl-1-picrylhdrazyl) radical enzymes were assayed...
Recent research suggests that adenosine receptors (ARs) influence many of the metabolic abnormalities associated with diabetes. A non-xanthine benzylidene indanone derivative 2-(3,4-dihydroxybenzylidene)-4-methoxy-2,3-dihydro-1 H-inden-1-one (2-BI), has shown to exhibit higher affinity at A1/A2A ARs compared caffeine. Due its structural similarity caffeine, and established antidiabetic effects current study was initiated explore possible effect 2-BI.The designed assess several A1 and/or A2A...
Type 2 diabetes (T2D) is a global health challenge with increased morbidity and mortality rates yearly. Herbal medicine has provided an alternative approach to treating T2D limited access formal healthcare. Tectona grandis being used traditionally in the treatment of diabetes. The present study investigated antidiabetic potential T. leaves different solvent extractions, crude extract that demonstrated best activity was further fractionated through solvent–solvent partitioning. ethyl acetate...
The unrelenting increase in the incidence of type 2 diabetes (T2D) necessitates urgent need for effective animal models to mimic its pathophysiology. Zebrafish possess human-like metabolic traits and share significant genetic similarities, making them valuable candidates studying disorders, including T2D. This review emphasizes critical role research, especially focusing on zebrafish as an alternative model organism. Different approaches a non-genetic T2D zebrafish, such glucose solution,...
The therapeutic effect of Cola nitida hot infusion against diabetes hepatic injury was investigated in livers diabetic rats. infused boiling water and concentrated.The concentrated administered to T2D rats at low high doses (150 300 mg/kg body weight (bw), respectively). normal group (positive control) another (negative were distilled water, while metformin served as the standard drug. A toxic that consists a dose C. nitida. After 6 weeks, sacrificed, their collected. They assayed for...
The ameliorating effect of different fractions Anonna muricata ethanol leaves extract in oxidative pancreatic injury as well their antihyperglycemic were investigated vitro and ex vivo. Oxidative was induced by incubating tissue with ferrous sulphate (FeSO4). antioxidative potentials the together its ability to inhibit carbohydrate digesting enzymes, intestinal glucose absorption, modulate muscle uptake determined. All significantly scavenge free radicals dose-dependent manner increase...