A5001831323- Antimicrobial Peptides and Activities
- Invertebrate Immune Response Mechanisms
- Essential Oils and Antimicrobial Activity
- Metal complexes synthesis and properties
- Bacterial biofilms and quorum sensing
- Marine Sponges and Natural Products
- Antimicrobial agents and applications
- Radical Photochemical Reactions
- Antifungal resistance and susceptibility
- Aquaculture disease management and microbiota
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Oral microbiology and periodontitis research
- Galectins and Cancer Biology
- Insect Pest Control Strategies
- Bioactive Natural Diterpenoids Research
- Glycosylation and Glycoproteins Research
- Photodynamic Therapy Research Studies
- Pharmacological Effects of Natural Compounds
- Wound Healing and Treatments
- Phytochemistry and Bioactivity Studies
- Chemistry and Chemical Engineering
- Seaweed-derived Bioactive Compounds
- Silk-based biomaterials and applications
- Alkaloids: synthesis and pharmacology
Universidade Federal do Ceará
2017-2024
Universidade de Fortaleza
2019
This study investigated the antibacterial activity of aqueous and organic extracts from 78 marine organisms, including seaweeds sponges, collected coastal zone Ceará, Brazil. Biological tissue were obtained by maceration using distilled water 50% acetonitrile. The tested against Gram-positive (Staphylococcus aureus Staphylococcus epidermidis) Gram-negative (Escherichia coli) bacterial strains disk diffusion method measuring inhibition diameters. Results showed that 30.7% organisms exhibited...
A new lectin from the marine sponge Chondrilla caribensis (CCL) was isolated by affinity chromatography in Sepharose 6B media. CCL is a homotetrameric protein formed subunits of 15,445 ±2 Da. The showed for disaccharides containing galactose and mucin. Mass spectrometric analysis revealed about 50% amino acid sequence CCL, which similarity with Aplysina lactuca. Secondary structure consisted 10% α-helix, 74% β-sheet/β-turn 16% coil, this profile unaltered broad range pH temperatures....
Metallocompounds have emerged as promising new anticancer agents, which can also exhibit properties to be used in photodynamic therapy. Here, we prepared two ruthenium-based compounds with a 2,2′-bipyridine ligand conjugated an anthracenyl moiety. These coded GRBA and GRPA contain or 1,10-phenathroline auxiliary ligands, respectively, provide quite distinct behavior. Notably, compound exhibited remarkably high photoproduction of singlet oxygen even water (ϕΔ = 0.96), almost twice that 0.52)....
The aim of this study was to investigate the antibacterial activity, antibiotic-associated synergy, and anti-biofilm activity ruthenium complex, cis-[RuCl2 (dppb) (bqdi)]2+ (RuNN). RuNN exhibited antimicrobial against Gram-positive bacteria with minimum inhibitory concentration (MIC) values ranging from 15.6 62.5 µg ml−1 bactericidal (MBC) 125 ml−1. A synergistic effect Staphylococcus spp. observed when combined ampicillin, range associated fractional index (FICI) 0.187 0.312. time-kill...
Photocleavage of an acyl hydrazone bridge was achieved by conjugating isoniazid to a ruthenium(<sc>ii</sc>) metal complex through the generation singlet oxygen, which released and activated anti-tuberculosis pro-drug isoniazid.
This study investigated the chemical composition and evaluated antibacterial antibiofilm activities of essential oils (EOs) extracted from Ruellia asperula (EORA) paniculata (EORP) against oral streptococci. The EO constituents were analyzed by gas chromatography/mass spectrometry. antimicrobial potential EOs was using minimum inhibitory concentration, bactericidal time-kill determination. Furthermore, quantification total biomass number viable cells in biofilms evaluated. major EORA...
In this study, the chemical composition of essential oil (EO) extracted from Croton blanchetianus Baill leaves was identified, and antimicrobial antibiofilm activities against Staphylococcus aureus, epidermidis, Escherichia coli strains were determined. Moreover, effects EO in combination with ampicillin tetracycline investigated. Thirty-four components, mainly mono-and sesquiterpenes that represented 94.05 % composition, identified EO. The showed bacteriostatic bactericidal all tested....
This study aims to evaluate the wound healing potential of lectin isolated from seeds Centrolobium microchaete (Mart. ex Benth) (CML) on cutaneous wounds in mice. CML did not show cytotoxicity murine dermal fibroblasts (L929 cell line). The treated with (200 μg/mL) showed a decrease area within 12 days post-operative (P.O.) when compared control. On 3rd and 7th day P.O., CML-treated group exhibited fibroblast proliferation neovascularization. 12th complete restructuring epithelial layer...
There has been growing effort in the scientific community to develop new antibiotics address major threat of bacterial resistance. One promising approach is use metal complexes that provide broader opportunities. Among these systems, polypyridine-ruthenium(II) have received particular attention as drug candidates. Here, we prepared two ruthenium(II) with formulation [Ru(DFO)(phtpy-R)Cl](PF
This study aimed to assess the combined antibacterial effect of lectins and antibiotics on S. aureus ATCC 25923, multidrug-resistant E. coli 11303 700698. Using checkerboard assay, we evaluated effects eight isolated from marine organisms with two common antibiotics, oxacillin tetracycline, three virulent bacterial strains. Initially, none tested exhibited when used individually. However, synergistic, additive, antagonistic, or no interaction. Overall, alone had efficacy oxacillin. On other...
Antimicrobial resistance (AMR) is a critical global public health problem. Many bacterial pathogens use biofilm formation as their main pathogenicity mechanism, practical tactic for surviving in natural settings and colonized host tissues. Research using ruthenium(II) complexes has demonstrated antibacterial action linked to photodynamic therapy, an alternate method of microbial control. Thus, this work, the photosensitive nitro complex [RuCl(NO2)(dppb)(4,4-Mebipy)] (I) was prepared X-ray...
A lectin from the marine sponge Haliclona (Reniera) implexiformis (HiL) was isolated by affinity chromatography on Sepharose™ matrix. HiL showed specificity for galactose and its derivatives. The glycoproteins porcine stomach mucin (PSM) bovine (BSM) were potent inhibitors. Hemagglutinating activity of maximal between pH 5.0 9.0. remained active until 60°C. presence CaCl2 EDTA did not affect hemagglutinating activity. In SDS-PAGE, a single band 20 kDa under reduced conditions, whereas in...