A5002680701- Electrohydrodynamics and Fluid Dynamics
- Electrospun Nanofibers in Biomedical Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Fluid Dynamics and Mixing
- Graphene and Nanomaterials Applications
- Mass Spectrometry Techniques and Applications
- Microfluidic and Bio-sensing Technologies
- Pickering emulsions and particle stabilization
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Wound Healing and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Minerals Flotation and Separation Techniques
- Heat Transfer and Boiling Studies
- Nerve injury and regeneration
- Ultrasound and Hyperthermia Applications
- Pancreatitis Pathology and Treatment
- Ultrasound and Cavitation Phenomena
- Surface Modification and Superhydrophobicity
- Bone Tissue Engineering Materials
- Advancements in Transdermal Drug Delivery
- Histone Deacetylase Inhibitors Research
University College London
2014-2025
Master's College
2022
Carleton University
2022
Transnational Press London
2014-2020
Imam Reza Hospital
2016
Mashhad University of Medical Sciences
2016
Targeted delivery of potent, toxic chemotherapy drugs, such as cisplatin, is a significant area research in cancer treatment. In this study, cisplatin was successfully encapsulated with high efficiency (>70%) poly (lactic-co-glycolic acid) polymeric nanoparticles by using electrohydrodynamic atomization (EHDA) where applied voltage and solution flow rate well the concentration polymer were varied to control size particles. Thus, produced three different drug:polymer ratios (2.5, 5 10wt%...
Electrohydrodynamic atomization (EHDA) is a key research area for producing micro and nano-sized structures. This process can be categorized into two main operating regimes: electrospraying particle generation electrospinning fibre production. Producing particles/fibres of the desired size or morphology depends on factors; properties polymeric solution used processing conditions including flow rate, applied voltage collection distance. In this work particle-fibre transition region was...
In order to maintain a stable cone-jet mode in electrospray low flow rates are used while most applications require high throughput. We compare two different designs of the multiple system increase output for large scale production applications. this study, solution was fed through four separate needles that were attached either circular or rectangular metallic plate connected voltage DC power supply. The behaviour jets as well deposition particles investigated. It shown throughput increased...
This work presents the effect of various surfactants on microbubble formation, size and stability in a capillary embedded T-Junction microfluidic device.
A novel method combining the principles of microfluidics and electrohydrodynamics for production monodisperse microbubbles has been invented.
Electrospraying (ES) is a state-of-the-art processing technique with the promise of achieving key nanotechnology and contemporary manufacturing needs. As versatile technique, ES can produce particles different sizes, morphologies, porosities by tuning list experiment parameters. However, this level precision demands an exhaustive trial-and-error approach, at high costs heavily relies on expertise. The present study demonstrates how machine learning (ML) expedite optimization process...
Abstract: Increasing the clinical efficacy of toxic chemotherapy drugs such as cisplatin (CDDP), via targeted drug delivery, is a key area research in cancer treatment. In this study, CDDP-loaded poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticles (NPs) were successfully prepared using electrohydrodynamic atomization (EHDA). The configuration was varied to control distribution CDDP within particles, and high encapsulation efficiency (>70%) achieved. NPs produced with either...
Imatinib is a chemotherapeutic agent known to cause severe side effects when administrated systemically. Encapsulating imatinib in co-polymer poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) offers targeted drug delivery. In this work, PLGA 50:50 and 75:25 NPs encapsulated using the electrohydrodynamic atomisation technique. All particles generated were spherical with smooth surface size distribution of 455±115 nm (PLGA 50:50) 363±147 75:25). Encapsulation was shown be higher than 75...
In recent years, there has been a surge of interest in the design, processing, and use core-sheath fibres, especially production wound healing bandages drug delivery. this research, novel pressurised gyration technique was utilised to create antibacterial fibre patches (tetracycline hydrochloride, TEHCL) using polyvinyl pyrrolidone (PVP) polycaprolactone (PCL). Antibiotic showed uniform fibres with porous surface giving rise biphasic delivery system, which provided an initial burst 30–48%...
Core/shell microparticles for development of drug delivery systems were prepared using co-axial electrohydrodynamic atomization technique in order to develop fixed dose combined formulations incorporating paracetamol and indomethacin as model drugs. The developed offered successful co-encapsulation with high encapsulation efficiencies 54% 69% indomethacin, respectively. further characterised respect their morphology, release profile possible interactions. In comparison the rate free...
This study was aimed at improving dissolution rate and sustained release of progesterone by varying copolymer composition polymer: drug ratio PLGA. Drug-loaded particles were prepared using electrohydrodynamic atomization. The effects on particle properties in vitro drug-release profile investigated. physical form the generated determined via X-ray powder diffraction (XRPD) Fourier transform infrared spectroscopy (FTIR). Drug found to be dependent composition, where increased with decreased...
Nanotechnology has become increasingly important in advancing the frontiers of many key areas healthcare, for example, drug delivery and tissue engineering.To fully harness benefits nanotechnology innovative manufacturing is necessary to mass produce nanoparticles nanofibers, two major types nanofeatures currently sought after immense utilitarian value healthcare.For are a enabler, structural mechanical mimicry attributes nanofiber which used as biomimetic agents. Nanoparticles &...
Electroconductive scaffolds can be a promising approach to repair conductive tissues when natural healing fails. Recently, nerve tissue engineering constructs have been widely investigated due the challenges in creating structure with optimized physiochemical and mechanical properties close native tissue. The goal of current study was fabricate graphene-containing polycaprolactone/gelatin/polypyrrole (PCL/gelatin/PPy) polycaprolactone/polyglycerol-sebacate/polypyrrole (PCL/PGS/PPy) intrinsic...
Single and coaxial electrospraying was used to prepare Eudragit L100-55 polymer microparticles containing prednisolone as the active pharmaceutical ingredient. Different compositions of were develop five different formulations with : drug ratios. The resultant had a toroidal shape narrow size distribution. Prednisolone present in an amorphous physical state, confirmed by X-ray diffraction analysis. Dissolution studies carried out order investigate feasibility proposed system for...
In this work, a major advance for the controlled production of monodisperse microbubbles, which are key constituent in many advanced technologies, has been invented using simple microfluidic technology.
There are several limitations with monodrug cancer therapy, including poor bioavailability, rapid clearance and drug resistance. Combination therapy addresses these by exploiting synergism between different drugs against cells. In particular, the combination of epigenetic therapies conventional chemotherapeutic agents can improve initial tumour response overcome acquired Co-encapsulation multiple therapeutic into a single polymeric nanoparticle is one many approaches taken to enhance effect...
Developing oral formulations to enable effective release of poorly water-soluble drugs like progesterone is a major challenge in pharmaceutics. Coaxial electrospray can generate drug-loaded nanoparticles strategic compositions and configurations enhance physiological dissolution bioavailability drug progesterone.