A5083095562- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Photoacoustic and Ultrasonic Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- HER2/EGFR in Cancer Research
- Photodynamic Therapy Research Studies
- Thermography and Photoacoustic Techniques
- Chemical Synthesis and Analysis
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Orthopaedic implants and arthroplasty
- Medical Imaging Techniques and Applications
- Toxin Mechanisms and Immunotoxins
- Cancer, Hypoxia, and Metabolism
- Optical Imaging and Spectroscopy Techniques
- Colorectal Cancer Treatments and Studies
- Ultrasound and Hyperthermia Applications
- Mathematical Biology Tumor Growth
- Protein purification and stability
- Ocular Disorders and Treatments
- Radioactive Decay and Measurement Techniques
University College London
2004-2019
CRUK Lung Cancer Centre of Excellence
2009-2019
Transnational Press London
2015-2017
Cancer Institute (WIA)
2014
Universitätsklinikum Gießen und Marburg
2012
London Cancer
2012
The Royal Free Hospital
1993-2004
University of Wisconsin–Madison
2002
Roland Hill (United Kingdom)
2001
Charing Cross Hospital
1985-1990
The use of a novel all-optical photoacoustic scanner for imaging the development tumor vasculature and its response to therapeutic vascular disrupting agent is described. employs Fabry-Perot polymer film ultrasound sensor mapping waves an image reconstruction algorithm based upon attenuation-compensated acoustic time reversal. system was used noninvasively human colorectal xenografts implanted subcutaneously in mice. Label-free three-dimensional vivo images whole tumors depths almost 10 mm...
The application of a photoacoustic imaging instrument based upon Fabry–Perot polymer film ultrasound sensor to the superficial vasculature is described. This approach provides backward mode-sensing configuration that has potential overcome limitations current piezoelectric detection systems used in imaging. system been evaluated by obtaining non-invasive images human and mouse skin as well models colorectal tumours. These studies showed can provide high-resolution 3D vascular structures...
A noninvasive, multimodal photoacoustic and optical coherence tomography (PAT/OCT) scanner for three-dimensional in vivo (3D) skin imaging is described. The system employs an integrated, all detection scheme both modalities backward mode utilizing a shared 2D with field-of-view of ~13 × 13 mm(2). waves were detected using Fabry Perot polymer film ultrasound sensor placed on the surface skin. transparent spectral range 590-1200 nm. This permits excitation beam (670-680 nm) OCT probe (1050 to...
A next generation maleimide–ADC is shown to have excellent stability in blood serum, as well high potency and selectivity <italic>in vitro</italic>.
Delivering potent, stable, targeted and<italic>in vivo</italic>efficacious antibody–drug conjugates (ADCs) using pyridazinedione functional disulfide re-bridging reagents.
Conjugation of next generation maleimides to engineered cysteines in a THIOMAB™ antibody delivers highly stable and potent antibody-drug conjugate.
Abstract: Increasing the clinical efficacy of toxic chemotherapy drugs such as cisplatin (CDDP), via targeted drug delivery, is a key area research in cancer treatment. In this study, CDDP-loaded poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticles (NPs) were successfully prepared using electrohydrodynamic atomization (EHDA). The configuration was varied to control distribution CDDP within particles, and high encapsulation efficiency (>70%) achieved. NPs produced with either...
The transcription factor Nrf2 is a key regulator of the cellular antioxidant response, and its activation by chemoprotective agents has been proposed as potential strategy to prevent cancer. However, activating mutations in pathway have found promote tumorigenesis certain models. Therefore, role cancer remains contentious.We employed well-characterized model stepwise human mesenchymal stem cell (MSC) transformation breast lines investigate oxidative stress during tumorigenesis. was studied...
Photoacoustic imaging combines both excellent spatial resolution with high contrast and specificity, without the need for patients to be exposed ionizing radiation. This makes it ideal study of physiological changes occurring during tumorigenesis cardiovascular disease. In order fully exploit potential this technique, new exogenous agents strong absorbance in near-infrared range, good stability biocompatibility, are required. paper, we report formulation characterization a novel series...
A study has been made of the sarcogenicity particles cobalt-chromium-molybdenum alloy. The were implanted as a dry powder into surgical incision dorsal paraspinal muscle adult female rats and guinea pigs. Two preparations used. In one, had size range 100-250 micrometers. This preparation was 51 Wistar rats. other, 0.5-50 micrometers, 85% being in 0.5-5 61 rats, 53 hooded 46 Dunkin Hartley Sham operations carried out on control group 50 No malignant neoplasms developed at test or operation...
Background Research using orthotopic and transgenic models of cancer requires imaging methods to non-invasively quantify tumour burden. As the choice appropriate modality is wide-ranging, this study aimed compare low-field (1T) magnetic resonance (MRI), a novel relatively low-cost system, against established preclinical techniques: bioluminescence (BLI), ultrasound (US), high-field (9.4T) MRI. Methods A model colorectal metastasis liver was in eight mice, which were imaged with each over...
Induction of apoptosis is often necessary for successful cancer therapy, and the non-invasive monitoring post-therapy could assist in clinical decision making. Isatins are a class compounds that target activated caspase-3 during apoptosis. Here we report synthesis 5-iodo-1,2,3-triazole (FITI) analog PET tracer [18F]ICMT11 as candidate imaging with SPECT, well PET. Labelling radioiodine (123,125I) was achieved 55 ± 12% radiochemical yield through chelator-accelerated one-pot cycloaddition...
AbstractSpecific low-energy pulsed electromagnetic fields (PEMF) induced, in certain circumstances, changes the activity of tyrosine hydroxylase (a marker for differentiation), level melanin (correlating with activity), cAMP, and mitosis, Cloudman S91 clone M3 murine melanoma cells. The observed were similar to those induced by alpha melanocyte stimulating hormone (MSH). A specific PEMF caused an additive increase hydroxylase, decrease mitosis MSH activators adenylate cyclase. Continuously...
Intra-arterial Lipiodol has been used to deliver targeted therapies primary, and some metastatic, liver cancers. Targeted radiotherapy by substituting the iodine in with 131Iodine (131I). Early clinical results are encouraging, but variable response may partly depend on local pharmacokinetics. This study evaluated vitro cytotoxic effects of 131I-Lipiodol human hepatocellular carcinoma (Hep-G2), colorectal metastatic cancer (SW620), hepatic (LoVo) umbilical vein endothelial cells (HUVEC) cell...