- Dental materials and restorations
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Genomics and Phylogenetic Studies
- Surgical Sutures and Adhesives
- Bone Tissue Engineering Materials
- Biomedical Ethics and Regulation
- Polymer Surface Interaction Studies
- Antibiotic Resistance in Bacteria
- Titanium Alloys Microstructure and Properties
- Bacterial biofilms and quorum sensing
- Cystic Fibrosis Research Advances
- Plant Pathogenic Bacteria Studies
- Tissue Engineering and Regenerative Medicine
- Microbial Community Ecology and Physiology
- Cardiac Valve Diseases and Treatments
- Anatomy and Medical Technology
- Endodontics and Root Canal Treatments
- Orthodontics and Dentofacial Orthopedics
- Microplastics and Plastic Pollution
- Dental Erosion and Treatment
- Trace Elements in Health
- Cell Adhesion Molecules Research
Milliman (United States)
2025
University of Liverpool
2005-2021
Public Health England
2019
University of Sri Jayewardenepura
2017
Integra (United States)
2015
Yale University
2010-2013
Forest Institute
2013
University of Connecticut
2010-2012
University of Waikato
2005
Royal Liverpool University Hospital
1993-2002
Abstract The corrosion of the pure metals aluminium, cobalt, copper, chromium, molybdenum, nickel, and titanium a cobalt‐chromium molybdenum casting alloy has been studied in buffered saline with without presence proteins serum albumin fibrinogen. aluminium was unaffected by protein. rates chromium nickel showed slight increase, while cobalt copper dissolved to very much greater extent However, inhibited
Abstract A combined histological, metallurgical, and clinical study has been made in 19 instances where a surgical operation had performed to remove titanium implant used the treatment of disease or trauma man. All implants were static devices such as pins, plates rods. Histological examination nonosseous tissue excised from adjacent was supplemented by estimation its content neutron activation analysis. The results indicate that some patients can be liberated into implants. phenomenon occur...
Rationale: Pseudomonas aeruginosa, the predominant cause of chronic airway infections patients with cystic fibrosis, exhibits extensive phenotypic diversity among isolates within and between sputum samples, but little is known about underlying genetic diversity.Objectives: To characterize population structure transmissible P. aeruginosa Liverpool Epidemic Strain in nine infer evolutionary processes associated adaptation to fibrosis lung.Methods: We performed whole-genome sequencing pooled...
Abstract Microbes that protect their hosts from pathogens are widespread in nature and attractive disease control agents. Given pathogen adaptation to barriers against infection can drive changes virulence, ‘defensive microbes’ may shape severity. Here we show co-evolving a microbe with host-protective properties ( Enterococcus faecalis ) Staphylococcus aureus within Caenorhabditis elegans drives the evolution of reduced virulence as by-product defensive microbe. Using both genomic...
Significance During chronic infection, bacterial pathogens undergo rapid evolutionary adaptation and extensive genetic diversification affecting patient symptoms treatment outcomes. Temperate phages are common in pathogen genomes, phage particles can reach high abundance human infections, but their role evolution is unclear. Using experimental population genomics, we show that temperate found infections accelerated by increasing the supply of beneficial mutations imposing strong selection on...
To characterise Pseudomonas aeruginosa populations during chronic lung infections of non-cystic fibrosis bronchiectasis patients, we used whole-genome sequencing to 1) assess the diversity P. and prevalence multilineage infections; 2) seek evidence for cross-infection or common source acquisition; 3) adaptations. 189 isolates, obtained from sputa 91 patients attending 16 adult centres in UK, were sequenced. Bronchiectasis isolates representative wider population. Of 24 whom multiple...
Abstract Specimens of 14 C‐labeled poly(ethylene terephthalate), nylon 66, and poly(methyl methacrylate) have been synthesized exposed, in vitro , to a number enzyme solutions. Poly(ethylene terephthalate) was found be affected by esterase papain, although different ways, but not trypsin or chymotrypsin. Nylon 66 unaffected degraded the other three. Poly(methyl any these enzymes. This indicates that some nominally stable polymers are susceptible degradation enzymes under circumstances. The...
The clinical features and necropsy findings are described for seven trekkers in the Himalayas whose deaths were related to high altitude. fatal outcome was due serious pulmonary cerebral disease. Oedema of lungs brain prominent but so thrombosis haemorrhage, acute mountain sickness that have received insufficient recognition past. Most men middle aged. Some began their trekking soon after flying altitude before becoming acclimatised some remained at or climbed even higher despite development...
Abstract The noncompetitive adsorption of the proteins albumin and fibrinogen onto 17 different metal surfaces has been studied in vitro using 125 I‐labeled proteins. Although many metals showed very similar characteristics to polymers, several them adsorbed considerably greater amounts. Copper, gold, silver were most significant this respect, all three being face‐centered cubic, group 1B known bind types protein vivo . desorption was an model which preproteinized implanted rats. There...