David Williams

ORCID: 0000-0002-6925-7408
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About
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Research Areas
  • Dental materials and restorations
  • Orthopaedic implants and arthroplasty
  • Dental Implant Techniques and Outcomes
  • Electrospun Nanofibers in Biomedical Applications
  • biodegradable polymer synthesis and properties
  • Genomics and Phylogenetic Studies
  • Surgical Sutures and Adhesives
  • Bone Tissue Engineering Materials
  • Biomedical Ethics and Regulation
  • Polymer Surface Interaction Studies
  • Antibiotic Resistance in Bacteria
  • Titanium Alloys Microstructure and Properties
  • Bacterial biofilms and quorum sensing
  • Cystic Fibrosis Research Advances
  • Plant Pathogenic Bacteria Studies
  • Tissue Engineering and Regenerative Medicine
  • Microbial Community Ecology and Physiology
  • Cardiac Valve Diseases and Treatments
  • Anatomy and Medical Technology
  • Endodontics and Root Canal Treatments
  • Orthodontics and Dentofacial Orthopedics
  • Microplastics and Plastic Pollution
  • Dental Erosion and Treatment
  • Trace Elements in Health
  • Cell Adhesion Molecules Research

Milliman (United States)
2025

University of Liverpool
2005-2021

Public Health England
2019

University of Sri Jayewardenepura
2017

Integra (United States)
2015

Yale University
2010-2013

Forest Institute
2013

University of Connecticut
2010-2012

University of Waikato
2005

Royal Liverpool University Hospital
1993-2002

10.1243/emed_jour_1981_010_004_02 article EN Engineering in Medicine 1981-01-01

Abstract The corrosion of the pure metals aluminium, cobalt, copper, chromium, molybdenum, nickel, and titanium a cobalt‐chromium molybdenum casting alloy has been studied in buffered saline with without presence proteins serum albumin fibrinogen. aluminium was unaffected by protein. rates chromium nickel showed slight increase, while cobalt copper dissolved to very much greater extent However, inhibited

10.1002/jbm.820160205 article EN Journal of Biomedical Materials Research 1982-03-01

Abstract A combined histological, metallurgical, and clinical study has been made in 19 instances where a surgical operation had performed to remove titanium implant used the treatment of disease or trauma man. All implants were static devices such as pins, plates rods. Histological examination nonosseous tissue excised from adjacent was supplemented by estimation its content neutron activation analysis. The results indicate that some patients can be liberated into implants. phenomenon occur...

10.1002/jbm.820070607 article EN Journal of Biomedical Materials Research 1973-11-01

10.1007/bf00752233 article EN Journal of Materials Science 1982-05-01

Rationale: Pseudomonas aeruginosa, the predominant cause of chronic airway infections patients with cystic fibrosis, exhibits extensive phenotypic diversity among isolates within and between sputum samples, but little is known about underlying genetic diversity.Objectives: To characterize population structure transmissible P. aeruginosa Liverpool Epidemic Strain in nine infer evolutionary processes associated adaptation to fibrosis lung.Methods: We performed whole-genome sequencing pooled...

10.1164/rccm.201409-1646oc article EN American Journal of Respiratory and Critical Care Medicine 2015-01-15

Abstract Microbes that protect their hosts from pathogens are widespread in nature and attractive disease control agents. Given pathogen adaptation to barriers against infection can drive changes virulence, ‘defensive microbes’ may shape severity. Here we show co-evolving a microbe with host-protective properties ( Enterococcus faecalis ) Staphylococcus aureus within Caenorhabditis elegans drives the evolution of reduced virulence as by-product defensive microbe. Using both genomic...

10.1038/ncomms13430 article EN cc-by Nature Communications 2016-11-15

Significance During chronic infection, bacterial pathogens undergo rapid evolutionary adaptation and extensive genetic diversification affecting patient symptoms treatment outcomes. Temperate phages are common in pathogen genomes, phage particles can reach high abundance human infections, but their role evolution is unclear. Using experimental population genomics, we show that temperate found infections accelerated by increasing the supply of beneficial mutations imposing strong selection on...

10.1073/pnas.1520056113 article EN Proceedings of the National Academy of Sciences 2016-07-05

To characterise Pseudomonas aeruginosa populations during chronic lung infections of non-cystic fibrosis bronchiectasis patients, we used whole-genome sequencing to 1) assess the diversity P. and prevalence multilineage infections; 2) seek evidence for cross-infection or common source acquisition; 3) adaptations. 189 isolates, obtained from sputa 91 patients attending 16 adult centres in UK, were sequenced. Bronchiectasis isolates representative wider population. Of 24 whom multiple...

10.1183/13993003.02108-2016 article EN cc-by European Respiratory Journal 2017-04-01

10.1016/s0142-9612(02)00112-6 article EN Biomaterials 2002-09-01

Abstract Specimens of 14 C‐labeled poly(ethylene terephthalate), nylon 66, and poly(methyl methacrylate) have been synthesized exposed, in vitro , to a number enzyme solutions. Poly(ethylene terephthalate) was found be affected by esterase papain, although different ways, but not trypsin or chymotrypsin. Nylon 66 unaffected degraded the other three. Poly(methyl any these enzymes. This indicates that some nominally stable polymers are susceptible degradation enzymes under circumstances. The...

10.1002/jbm.820210805 article EN Journal of Biomedical Materials Research 1987-08-01

10.1016/0142-9612(88)90085-3 article EN Biomaterials 1988-05-01

The clinical features and necropsy findings are described for seven trekkers in the Himalayas whose deaths were related to high altitude. fatal outcome was due serious pulmonary cerebral disease. Oedema of lungs brain prominent but so thrombosis haemorrhage, acute mountain sickness that have received insufficient recognition past. Most men middle aged. Some began their trekking soon after flying altitude before becoming acclimatised some remained at or climbed even higher despite development...

10.1136/thx.38.9.646 article EN Thorax 1983-09-01

Abstract The noncompetitive adsorption of the proteins albumin and fibrinogen onto 17 different metal surfaces has been studied in vitro using 125 I‐labeled proteins. Although many metals showed very similar characteristics to polymers, several them adsorbed considerably greater amounts. Copper, gold, silver were most significant this respect, all three being face‐centered cubic, group 1B known bind types protein vivo . desorption was an model which preproteinized implanted rats. There...

10.1002/jbm.820190312 article EN Journal of Biomedical Materials Research 1985-03-01

10.1002/jbm.820210908 article EN Journal of Biomedical Materials Research 1987-09-01
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