A5100329671- Molecular Spectroscopy and Structure
- Advanced Chemical Physics Studies
- Metabolomics and Mass Spectrometry Studies
- Single-cell and spatial transcriptomics
- Catalytic C–H Functionalization Methods
- Advanced Proteomics Techniques and Applications
- Gene expression and cancer classification
- Mass Spectrometry Techniques and Applications
- Catalytic Cross-Coupling Reactions
- Spectroscopy and Laser Applications
- Electrochemical Analysis and Applications
- Analytical chemistry methods development
- Electrochemical sensors and biosensors
- Catalytic Alkyne Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis of Indole Derivatives
- Quantum, superfluid, helium dynamics
- Petroleum Processing and Analysis
- Cell Image Analysis Techniques
- Natural Antidiabetic Agents Studies
- Grey System Theory Applications
- Biochemical Analysis and Sensing Techniques
- Bioinformatics and Genomic Networks
- Food Allergy and Anaphylaxis Research
- Electrocatalysts for Energy Conversion
University of California, Los Angeles
2021-2024
Xinxiang Medical University
2023-2024
Shanghai University
2024
Shanxi Medical University
2024
Wuhan University of Science and Technology
2024
China Agricultural University
2023
Beijing Forestry University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Tsinghua University
2020
Qufu Normal University
2018
A visible-light-promoted approach for the regioselective selenylation of 4-amino substituted coumarins has been initially realized under metal- and photocatalyst-free conditions at room temperature.
Abstract Deep proteomics profiling using labeled LC-MS/MS experiments has been proven to be powerful study complex diseases. However, due the dynamic nature of discovery mass spectrometry, generated data contain a substantial fraction missing values. This poses great challenges for analyses, as many tools, especially those high dimensional data, cannot deal with values directly. To address this problem, NCI-CPTAC Proteogenomics DREAM Challenge was carried out develop effective imputation...
Decarbonylative borylation of aryl anhydrides by rhodium catalysis has been reported. A base-free system with Rh(PPh
Double dipping is a well-known pitfall in single-cell and spatial transcriptomics data analysis: after clustering algorithm finds clusters as putative cell types or domains, statistical tests are applied to the same identify differentially expressed (DE) genes potential cell-type spatial-domain markers. Because that contribute inherently likely be identified DE genes, double can result false-positive markers, especially when spurious, leading ambiguously defined domains. To address this...
Advances in mass spectrometry (MS) have enabled high-throughput analysis of proteomes biological systems. The state-of-the-art MS data relies on database search algorithms to quantify proteins by identifying peptide-spectrum matches (PSMs), which convert spectra peptide sequences. Different use distinct strategies and thus may identify unique PSMs. However, no existing approaches can aggregate all user-specified with a guaranteed increase the number identified peptides control false...
Scope Oral food challenges (OFCs) are currently the gold standard for determining clinical reactivity of allergy (FA) but time‐consuming, expensive, and risky. To screen novel peripheral biomarkers FA characterize aberrant lipid metabolism in serum, 24 rats divided into four groups: peanut, milk, shrimp (PA, MA, SA, respectively) control groups, with six each group, used widely targeted lipidomics transcriptomics analysis. Methods results Widely reveal 144, 162, 206 differentially...
In typical single-cell RNA-seq (scRNA-seq) data analysis, a clustering algorithm is applied to find putative cell types as clusters, and then statistical differential expression (DE) test employed identify the differentially expressed genes between clusters. However, this common procedure uses same twice, an issue known "double dipping": used twice define clusters potential DE cell-type marker genes, leading false-positive even when are spurious. To overcome challenge, we propose ClusterDE,...
A palladium-catalyzed highly regio- and stereoselective reaction of alkynyl aryl iodide with allenyl malonates was realized to afford a series bicyclic compounds.
The microwave spectrum of the mono-fluoro-benzoic acids, 2-fluoro-, 3-fluoro-, and 4-fluoro-benzoic acid have been measured in frequency range 4-14 GHz using a pulsed beam Fourier transform spectrometer. Measured rotational transition lines were assigned fit rigid rotor Hamiltonian. Assignments made for 3 conformers 2-fluorobenzoic acid, 2 3-fluorobenzoic 1 conformer 4-fluorobenzoic acid. Additionally, gas phase homodimer was detected, spectra showed evidence proton tunneling. Experimental...
We have developed a new method for synthesizing chiral isotwistane and homoisotwistane skeletons as well aminocyclitols in highly stereoselective manner. These results were achieved through the use of common intermediate, which was derived from ytterbium-catalyzed asymmetric Diels-Alder reaction Danishefsky diene.
A novel strategy for the selective synthesis of ( E )-vinyl sulfone derivatives from p -tosylmethyl isocyanide (TosMIC) and ortho -substituted benzaldehydes has been established.
Insulin analogs are currently the most often prescribed medications for treating type 2 diabetes mellitus (T2DM). However, because of inherent flaws and restrictions administration methods, there is no comprehensive plan managing diabetes. As a result, its crucial to research treatment plans based on available traits T2DM. Natural products play as key role in drug discovery. Although many articles have been published antidiabetic potential natural products, few product-based molecules...
Abstract Palladium‐catalyzed bicyclization of 1‐(2,2‐dibromovinyl)‐2‐alkenylbenzene with allenyl malonates has been achieved to afford a series bicyclic compounds. The protocol involves intermolecular carbopalladation allenes/cyclization/internal Heck reaction. Three C−C bonds and two rings are formed in one step.
Abstract Single-cell RNA sequencing (scRNA-seq) captures whole transcriptome information of individual cells. While scRNA-seq measures thousands genes, researchers are often interested in only dozens to hundreds genes for a closer study. Then question is how select those informative from data. Moreover, single-cell targeted gene profiling technologies gaining popularity their low costs, high sensitivity, and extra (e.g., spatial) information; however, they typically can measure up few...
The selective oxidation of C(sp 3 )–H was achieved by the MnO 2 /CNTs/Gr electrocatalyst: 81.03% faradaic efficiency and 82.73% selectivity p -methoxy benzaldehyde were obtained.
Abstract Advances in mass spectrometry (MS) have enabled high-throughput analysis of proteomes biological systems. The state-of-the-art MS data relies on database search algorithms to quantify proteins by identifying peptide-spectrum matches (PSMs), which convert spectra peptide sequences. Different use distinct strategies and thus may identify unique PSMs. However, no existing approaches can aggregate all user-specified with a guaranteed increase the number identified peptides control false...
The microwave spectrum of the mono-fluoro-benzoic acids, 2-fluoro-, 3-fluoro-, and 4-fluoro-benzoic acid have been measured in frequency range 4-14 GHz using a pulsed beam Fourier transform spectrometer. Measured rotational transition lines were assigned fit rigid rotor Hamiltonian. Assignments made for 3 conformers 2-fluorobenzoic acid, 2 3-fluorobenzoic 1 conformer 4-fluorobenzoic acid. Additionally, gas phase homodimer was detected, spectra showed evidence proton tunneling. Experimental...