A5068853457- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Trauma Management and Diagnosis
- Organ Transplantation Techniques and Outcomes
- Cardiac Structural Anomalies and Repair
- Medical Imaging and Pathology Studies
- Cardiac, Anesthesia and Surgical Outcomes
University of Michigan
2019-2022
Michigan Medicine
2019
Preservation of a donor heart for transplantation is limited to 6–8 hours. Based on our demonstration 12 hour perfusion with plasma cross circulation, this study aimed evaluate ex vivo (EVHP) up 72 hours using circulation (XC-plasma) from live, awake paracorporeal sheep (PCS). Six ovine hearts were perfused at rate 1 L/min PCS. Controls seven without circulation. Experiments electively ended hours, and epinephrine (0.1 mg) was delivered demonstrate hormonal responsiveness. All controls...
Children with end-stage lung failure awaiting transplant would benefit from improvements in artificial technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work, we designed, fabricated, and tested the Pediatric MLung-a dual-inlet hollow fiber based on concentric gating, which has rated flow of 1 L/min, pressure drop 25 mm Hg at flow. This device future iterations current design are designed to relieve arterial hypertension, provide support, reduce...
Extracorporeal life support (ECLS) has grown in its application since first clinical description the 1970s. The technology been used to a wide variety of mechanical modalities and diseases, including respiratory failure, cardiorespiratory cardiac failure. Over many decades safety efficacy studies, followed by randomized trials thousands uses, ECLS is considered as an accepted treatment option for severe pulmonary selected cardiovascular involves use artificial organs, membrane lung blood...
Blood lactate and blood pressure measurements are important predictors of life-threatening complications after infant open-heart surgeries requiring cardiopulmonary bypass (CPB). We have developed an intravascular nitric oxide (NO)-releasing 5-Fr catheter that contains a sensor for continuous in-blood monitoring dedicated lumen third-party attachment. This device has antimicrobial antithrombotic properties can be implanted intravascularly. The importance this design is its ability to inhibit...
Introduction: Nicorandil is a coronary vasodilator for treatment of ischemia-induced angina. Studies suggest nicorandil may offer myocardial protection against regional ischemia-reperfusion (IR) injury during artery bypass grafting in adults. The impact on global IR-induced and left ventricular (LV) dysfunction after cardiopulmonary (CPB) cardioplegic arrest (CA) has not been investigated children. Hypothesis: attenuates IR LV CPB CA an immature animal model. Methods: Anesthetized piglets...