A5066718473- Mechanical Circulatory Support Devices
- Nanoparticle-Based Drug Delivery
- Congenital Diaphragmatic Hernia Studies
- Electrospun Nanofibers in Biomedical Applications
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Polymer Surface Interaction Studies
- Coronary Interventions and Diagnostics
- Microfluidic and Capillary Electrophoresis Applications
- Neonatal Respiratory Health Research
- Hepatitis C virus research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Medical Imaging and Pathology Studies
- Silicone and Siloxane Chemistry
- Blood properties and coagulation
- Angiogenesis and VEGF in Cancer
- Infant Development and Preterm Care
- Simulation-Based Education in Healthcare
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
- Injury Epidemiology and Prevention
- Infrared Thermography in Medicine
VA Ann Arbor Healthcare System
2016-2025
University of Michigan
2013-2024
Michigan United
2014-2023
St Vincent's Hospital
2018-2022
Michigan Medicine
2021-2022
The University of Melbourne
2022
Royal Belfast Hospital for Sick Children
2000-2019
RWTH Aachen University
2017
Many variants of vascular-targeted carriers (VTCs) have been investigated for therapeutic intervention in several human diseases. However, order to optimize the functionality VTC vivo, carriers' physical properties, such as size and shape, are important considerations a design that evades reticuloendothelial system (RES) successfully interacts with targeted vessel wall. Nonetheless, little evidence has presented on role VTC's interactions vascular wall, particularly microcirculation. Thus,...
Blood–material interactions are crucial to the lifetime, safety, and overall success of blood contacting devices. Hydrophilic polymer coatings have been employed improve device lifetime by shielding materials from natural foreign body response, primarily intrinsic pathway coagulation cascade. These ability repel proteins, cells, bacteria, other micro-organisms. Coatings desired long-term stability, so that nonthrombogenic nonfouling effects gained long lasting. Unfortunately, there exist...
Due to the role of nitric oxide (NO) in regulating a variety biological functions humans, numerous studies on different NO releasing/generating materials have been published over past two decades. Although has demonstrated be strong antimicrobial and potent antithrombotic agent, NO-releasing (NOrel) polymers not reached clinical setting. While increasing concentration donor polymer is common method prolong NO-release, this should at cost mechanical strength or biocompatibility original...
The importance of the size targeted, spherical drug carriers has been previously explored and reviewed. Particle shape emerged as an equally important parameter in determining vivo journey efficiency carrier systems. Researchers have invented techniques to better control geometry particles many different materials, which allowed for exploration role particle phases delivery. biological processes include clearance by immune system, trafficking target tissue, margination endothelial surface,...
This study is focused on the application of a dual surface coating poly(dimethylsiloxane) (PDMS) flow chambers, which aims to inhibit contact activation pathway coagulation. Polyethylene glycol (PEG) commonly used biocompatible molecule due its hydrophilic nature and capacity reduce protein adsorption. Corn trypsin inhibitor (CTI) selective Factor XII, initial factor responsible for activating intrinsic By sequentially applying these two coatings PDMS substrates, we expect PEG-CTI decrease...
Artificial lungs have been used in the clinic for multiple decades to supplement patient pulmonary function. Recently, small-scale microfluidic artificial (μAL) demonstrated with large surface area blood volume ratios, biomimetic flow paths, and pressure drops compatible pumpless operation. Initial devices rates μl/min ml/min range exhibited excellent gas transfer efficiencies; however, current manufacturing techniques may not be suitable scaling up human applications. Here, we present a new...
Microfluidic artificial lungs (μALs) are being researched for future clinical use due to the potential increased gas exchange efficiency, small blood contacting surface area, priming volume, and biomimetic flow paths. However, a current roadblock is need stack hundreds thousands of these small-scale μALs in parallel reach clinically relevant flows. The so many layers not only increases complexity projected cost manufacture μAL, but also could result devices which cumbersome, and, therefore,...
The nanoscale plasma protein interaction with intravenously injected particulate carrier systems is known to modulate their organ distribution and clearance from the bloodstream. However, role of this in prescribing adhesion carriers vascular wall remains relatively unknown. Here, we show that vascular-targeted poly(lactide-co-glycolic-acid) (PLGA) spheres endothelial cells significantly inhibited human blood flow, up 90% reduction observed relative simple buffer depending on particle size...
Introduction: Commercial membrane lungs are designed to transfer a specific amount of oxygen per unit venous blood flow. Membrane much more efficient at removing CO 2 than adding oxygen, but the range is rarely reported. Methods: were studied with goal evaluating removal capacity. was measured in 4 commercial under standardized conditions. Conclusion: clearance can be greater times that given flow when gas ratio elevated 4:1 or 8:1. The less dependent on surface area and configuration...
Current hollow fiber membrane lungs feature a predominantly straight blood path length across the bundle, resulting in limited O2 transfer efficiency because of diffusion boundary layer effect. Using computational fluid dynamics and optical flow visualization methods, lung was designed comprising unique concentric circular paths connected by gates. The prototype lung, surface area 0.28 m, has rated 2 L/min, oxygenation is 357 ml/min/m. CO2 clearance 200 ml/min at flow. Given its high gas...
Children with end-stage lung failure awaiting transplant would benefit from improvements in artificial technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work, we designed, fabricated, and tested the Pediatric MLung-a dual-inlet hollow fiber based on concentric gating, which has rated flow of 1 L/min, pressure drop 25 mm Hg at flow. This device future iterations current design are designed to relieve arterial hypertension, provide support, reduce...
Microfluidic artificial lungs (μALs) are being investigated for their ability to closely mimic the size scale and cellular environment of natural lungs. Researchers have developed μALs with small capillary diameters (10–50 µm; increase gas exchange efficiency) large (~100 simplify design construction). However, no study has directly impact height on μAL properties. Here, we use Murray’s law Hagen-Poiseuille equation single-layer, small-scale heights between 10 100 µm. Each µAL contained two...
A laptop-driven, benchtop control system that automatically adjusts carbon dioxide (CO 2 ) removal in artificial lungs (ALs) is described. The proportional-integral-derivative (PID) feedback controller modulates pump-driven air sweep gas flow through an AL to achieve a desired exhaust CO partial pressure (EGCO ). When EGCO increases, the servoregulator and rapidly increases remove more . If decreases, decreases reduce removal. System operation was tested for 6 hours vitro using bovine blood...
The goal of the low-resistance pediatric artificial lung (PAL-LR) is to serve as a pumpless bridge-to-transplant device for children with end-stage failure. PAL-LR doubles exposed fiber length previous PAL design. In vitro and in vivo studies tested hemocompatibility, flow, gas exchange pressure drop performance. For tests, average rated blood flow (outlet SO 2 95%) was 2.56 ± 0.93 L/min 25.88 0.90 mm Hg. At targeted rate 1 L/min, 8.6 Hg compared 25 PAL. O CO transfer rates were 101.75 10.81...
HBV RNA is used as a marker of cccDNA transcription and applicable in the setting nucleos(t)ide analog (NA) treatment, which suppresses DNA. Traditional assays for quantification rely on labor-intensive 3'RACE targeting polyA tail. In this study, high-throughput Roche cobas®HBV investigational assay was assessed cobas® 6800 automated platform. Of 969 samples collected NA treatment cessation trial, tested cobas assay, 249 were analyzed sensitivity, reproducibility, sample type applicability,...
Purpose: This work focuses on the development of Low Resistance Pediatric MLung (PAL-LR) with goal serving as a pumpless (pulmonary artery to left atrium) bridge-to-transplant device for small children end-stage lung failure. Methods: The PAL-LR doubles exposed fiber length Artificial MLung. 9 MLungs were fabricated using polymethylpentene fibers (surface area: 0.44 m2). In vitro benchtop studies tested gas exchange and pressure drop performance (n=6). an acute in vivo study, 3 PAL-LRs...