A5034640290- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Crystal structures of chemical compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Catalytic C–H Functionalization Methods
- Multicomponent Synthesis of Heterocycles
- Molecular spectroscopy and chirality
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Fluorine in Organic Chemistry
- Chemical Thermodynamics and Molecular Structure
- Synthesis and Properties of Aromatic Compounds
- Asymmetric Synthesis and Catalysis
- Metal complexes synthesis and properties
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Reactions
- Synthesis and biological activity
- Synthetic Organic Chemistry Methods
- Luminescence and Fluorescent Materials
- Molecular Spectroscopy and Structure
- Polymer composites and self-healing
- Photochromic and Fluorescence Chemistry
- Coordination Chemistry and Organometallics
- Magnetism in coordination complexes
University of Antwerp
2014-2024
Province of Antwerp
2016-2018
Faculty (United Kingdom)
2018
Vrije Universiteit Amsterdam
2014-2016
Karel de Grote University College
2009-2012
Université Libre de Bruxelles
2008-2011
Abbès Laghrour University of Khenchela
2010
National Taiwan University
2008
University at Buffalo, State University of New York
2007-2008
Youngstown State University
2004
We report a highly diastereoselective interrupted Ugi reaction to construct broad range of structurally congested and stereochemically complex spiroindolines from tryptamine-derived isocyanides. The is facilitated by using fluorinated alcohols (TFE or HFIP) as solvents tolerates amines, aldehydes 2-isocyanoethylindoles give polycyclic products in moderate excellent yields.
The N-iodosuccinimide-mediated spirocyclization of tryptamine-derived isocyanides to generate spiroindolenines is reported. products contain both an imine and imidoyl iodide as flexible handles for follow-up chemistry. Nucleophilic addition typically occurs chemoselectively on the moiety with complete diastereoselectivity, providing opportunities construction complex molecular frameworks. synthetic potential method was showcased in formal total synthesis (±)-aspidofractinine.
The use of polyurethanes and, therefore, the quantity its scrap are increasing. Considering thermoset characteristic most polyurethanes, circular recycling method is by means chemical depolymerization, for which glycolysis finding way into industry. main goal polyurethane to recover polyols used, but only limited attempts were made toward recovering aromatic dicarbamate residues and derivates from used isocyanates. By split-phase method, recovered form a top-layer phase bottom layer contain...
Two strategies, "hydrogenation–hydride reduction" and "quaternization–hydride reduction", are reported that make use of mild reaction conditions (room temperature) to efficiently remove the N-pyridin-2-yl directing group from a diverse set C-2-substituted piperidines were synthesized through directed Ru-catalyzed sp3 C–H functionalization. The deprotected products obtained in moderate good overall yields irrespective strategy followed, indicating both methods generally equally effective....
Polyurethanes are versatile materials, but their thermoset nature limits mechanical recycling as they do not melt under heating. However, chemical by depolymerization does yet provide complete circularity, given...
We report on the novel chiral push-pull chromophores derived from 6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine (Tröger's base skeleton). The synthesis of symmetrical featuring two identical acceptors, as well unsymmetrical only one acceptor is given. Symmetrical were prepared in enantiomerically pure form and their chiroptical properties investigated. Second-order nonlinear optical (NLO) new investigated with aid hyper-Rayleigh scattering (HRS). detailed theoretical analysis second-order...
Reaction of 5-phenyl-2,2'-bipyridine (L) with a mixture CuI or [Cu(CH3CN)4]BF4 and PPh3 leads to mononuclear heteroleptic complexes [CuL(PPh3)I] (1) [CuL(PPh3)2]BF4 (2). According X-ray diffraction, L crystallizes in the monoclinic space group P21/n, exhibiting disorder over four orientations. Complexes 1 2 crystallize groups P21/c P21, respectively. comprises discrete neutral molecule, while has an ionic structure containing [CuL(PPh3)2](+) BF4(-). Both structures reveal that each...
The self-assembly of functional polythiophenes was studied by a bottom-up approach "from molecule to polymer". synthesis and the X-ray structure 2,5-dibromo-3-styryl 3-2',3',4',5',6'-pentafluorostyryl-thiophenes revealed supramolecular arrangement controlled pi-pi interactions between aromatic rings. A [2 + 2] photocyclization reaction in solid state (E)-1-2',5'-dibromo-3'-thienyl-2-pentafluorophenylethene triggers formation rare cycloadduct comprising thiophene analysis confirmed its rctt...
The regiospecific total synthesis and characterization of anti-isomers 2,8-dialkylanthradithiophenes are described. "anti" structure the ADT derivatives is demonstrated by 13C NMR as well single crystal X-ray diffraction.
Tuberculosis is the leading cause of death worldwide from infectious diseases. With development drug-resistant strains Mycobacterium tuberculosis, there an acute need for new medicines with novel modes action. Herein, we report discovery and profiling a hydantoin-based family antimycobacterial inhibitors decaprenylphospho-β-d-ribofuranose 2-oxidase (DprE1). In this study, have prepared library more than 100 compounds evaluated them their biological physicochemical properties. The series...
Metal-organic framework (MOF)-74 is known for its effectiveness in selectively capturing carbon dioxide (CO
Abstract We report the palladium(II)‐catalyzed aerobic oxidative coupling of isocyanides with various (2‐aminophenyl)azoles using air as stoichiometric oxidant. A diverse range medicinally valuable azolo[ c ]quinazolines was obtained by this new approach. magnified image
Abstract The supramolecular organization of modified thiophenes resulting from N⋅⋅⋅I halogen bonding (XB) has been studied. X‐ray diffraction analyses two polymorphs the same complex showed an arrangement controlled by halogen‐bonded pyridyl and tetrafluoroiodobenzene rings, one case with other without presence different lone pair (lp)⋅⋅⋅π interactions, namely O⋅⋅⋅pyridyl I⋅⋅⋅tetrafluoroiodobenzene contacts. To shed light on interplay between these quantum mechanical calculations were...
We developed two Ugi-type three-component reactions of spirooxindole-fused 3-thiazolines, isocyanides, and either carboxylic acids or trimethylsilyl azide, to give highly functionalized thiazolidines. Two diverse libraries were generated using practical robust procedures affording the products in typically good yields. The obtained thiazolidines proved be suitable substrates for further transformations. Notably, both Ugi-Joullié azido-Ugi resulted diastereoselective, predominantly...
The complexes [CuL(PPh<sub>3</sub>)Hal] (L = 5-phenyl-2,2′-bipyridine, Hal Cl<sup>−</sup>, Br<sup>−</sup>) are emissive in the solid state at 298 K, with maxima 596 and 610 nm, respectively, due to a (M + Hal)LCT excited state.
An unforeseen twist in a seemingly trivial Bischler–Napieralski reaction led to the selective formation of an unexpected carbazole product. The proved be general, providing access range diversely substituted carbazoles from readily available substrates. Judicious variation substituents revealed complex cascade mechanism comprising no less than 10 elementary steps, that could diverted multiple ways toward various other derivatives.
Abstract [Zn(TA) 2 (H O) ] (H‐TA=tiglic acid) has been embedded in a framework composed of CECR (CECR= C ‐ethylcalix[4]resorcinarene) molecules to examine its E → Z photoisomerization periodic framework. The tiglic acid CECR‐[Zn(TA) ⋅ 4 H O proceeds without the [2+2]‐dimerization reaction that often occurs crystals uncomplexed analogues, and breakdown crystal lattice frequently neat crystals. two Zn‐coordinated TA are located different size cavities. rate constants isomerization strongly...
Abstract The metal‐free reaction of terminal arylacetylenes with α,α‐dichloroaldimines in 1,1,1,3,3,3‐hexafluoro‐2‐propanol as the sole solvent results rapid and selective formation γ,γ‐dichloro‐β‐amino ketones. In this expected dichlorinated propargylamines and/or allylic amines are not formed. dichloromethylene moiety aldimine acts an activating group is essential to accomplish transformation. Electron‐rich acetylenes lead best work well all imines (with or without α′‐H at nitrogen...
A stereoselective intramolecular Tsuji–Trost cascade cyclization of (homo)allylic vicinal diacetates with a pendant β-ketoamide or related carbon nucleophile to give γ-lactam-fused vinylcyclopropanes is reported. In addition two new rings, the products contain three C–C stereocenters (two which are quaternary) 9:1 dr. Moreover, reaction proceeds in >94% enantiospecificity optically enriched starting materials, using an inexpensive carbohydrate as source chirality.
Three novel coordination compounds were successfully isolated using rare and poorly studied 5-phenyl-2,2′-bipyridine (LI) completely unexplored 6-phenyl-3-(pyridin-2-yl)-1,2,4-triazine (LII) ligands with AgNO3, namely, [Ag(LI)2]NO3·0.5H2O (1), [Ag(LI)PPh3NO3]·0.5CH2Cl2 (2), [Ag2(LII)2(H2O)2](NO3)2 (3). 1 can be converted into 2 upon reacting PPh3, while no conversion was observed for 3. The formation of 3 templated through anion−π-system interactions between the NO3– anions electron...